Award Data

This Small Business Innovation Research (SBIR) Phase II project will focus on the development of a commercial process for the growth of Neodymium Yttrium Vanadate (Nd: YVO4) single crystals for use in solid-state lasers. This research will generate the commercially viable conditions for growth of large boules of single crystals suitable for use in diode pumped solid-state lasers. The hydrothermal ...

DESCRIPTION (provided by applicant): This is the follow-on Phase II SBIR proposal to continue the project Novel Neurotensin Analogs as Antischizophrenics (MH-65099) under PA-06-079 (Pharmacological Agents and Drugs for Mental Disorders). There exists a critical clinical need for the identification and development of novel therapies for psychosis, a major unmet medical need. Low levels of the bra ...

The development of a process to produce low defect density silicon carbide (SiC) boules at high growth rates will significantly reduce the cost of wafers and thus accelerate the rapid commercialization of SiC for high power and high temperature device applications. The objectives of this Phase II project is to improve the process development of a radically new approach to grow bulk SiC of a singl ...

This Small Business Innovation Research (SBIR) project will develop a highly accurate temperature measurement system that can be used in optimizing the growth of high brightness light emitting diodes for solid state lighting applications. This product does not currently exist due to technical difficulties in measuring the substrate or gallium nitride (GaN) epilayer in a region where they ab ...

DESCRIPTION (provided by applicant): Transplantation of islets of Langerhans for the clinical treatment of Type I diabetes has had a resurgence of interest due to results obtained using the "Edmonton protocol". However, at this time, procurement of donor pancreases for islet isolation and transplantation is in its infancy. Most pancreases at more remote donor sites are not procured due to justifi ...

DESCRIPTION (provided by applicant): The overall objective of this proposal is to define the hypothermic storage conditions and shelf life for tissue engineered cartilage constructs (TECCs) required for commercial manufacturing and distribution. Preliminary studies employing TECCs have demonstrated that chondrocyte viability and construct biochemistry were significantly impacted by hypothermic sto ...

DESCRIPTION (provided by applicant): In-vitro drug testing on precision-cut liver slices (PCLS) provides the most realistic biochemical metabolic profile of in-situ conditions for predicting drug toxicity and metabolism during early stage drug development. An ample supply of cryopreserved human liver slices obtained from viable donor livers and hepatic resects of split liver transplant surgerie ...

DESCRIPTION (provided by applicant): Available methods for biological molecular structure determination, based primarily on x-ray crystallography and Nuclear Magnetic Resonance (NMR) solution methods, have limitations. While the x-ray methods are several orders of magnitude faster, NMR techniques are required to obtain dynamical information, or information on biological molecules in their native e ...

The Architecture Analysis and Design Language (AADL) is an SAE standard language for describing the software and hardware architecture of performance-critical real-time systems. In addition, the AADL standard allows the definition of annexes, i.e., formal extensions to the standard language to enhance the design specifications of hardware or software components. We propose to leverage the AADL la ...

This STTR Phase II project continues the development of a new glass (designated MM-i) for ion-exchange glass waveguides and amplifiers used in l.55 um optical communication systems. There is excellent commercial potential for these glass materials and the waveguide lasers (lossless splitters) and optical amplifiers that may be fabricated from them. To date, development efforts in the communication ...