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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 7717 results
  1. Wide dynamic range x-ray Mixed-Mode Pixel Array Detector

    SBC: Sydor Instruments, LLC            Topic: 09a

    Synchrotron light sources and X-ray free electron lasers are now generating shorter pulses with more intense light than ever before possible. The capabilities of these new sources grant unprecedented access into the workings of the natural world. X-ray detectors, as they currently stand, cannot accommodate the large dynamic range of collected x-rays in modern scattering experiments. This capabilit ...

    SBIR Phase II 2018 Department of Energy
  2. Knowledge Management System for Multilingual Health Content

    SBC: Transcendent International, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of the proposed project is to develop an advanced, web-based knowledge management system for the creation and distribution of multilingual, patient-oriented documents. The system provides a vast library of pre-translated documents and document templates for medical, educational, and administrative materials used in patient-care. System users will be abl ...

    SBIR Phase II 2009 Department of Health and Human Services
  3. Human PSMA MAb Radioimmunotherapy for Prostate Cancer

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    Prostate cancer is the most common cancer of men in the United States with approximately 189,000 new cases and 30,000 deaths in 2002. Recurrent disease can be controlled temporarily with androgen ablation. However, almost all prostate carcinomas eventuall

    SBIR Phase II 2004 Department of Health and Human Services
  4. Development of PSMA-based recombinant protein vaccines

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Prostate cancer is the most common cancer of men in the United States with approximately 189,000 new cases and 30,000 deaths in 2002. Recurrent disease can be controlled temporarily with androgen ablation. However, alm

    SBIR Phase II 2004 Department of Health and Human Services
  5. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo diseasemucopolysaccharidosis type IIIMPS IIIis a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologicslowing of developmentsevere behavioral problemsprogressive cognitive declinedementiaand decline in motor skills leading to immobilityunresponsivenessand deathWe have focused on MPS IIID caused by a deficiency of a ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Humanized PRO 140 for CCR5-Targeted Therapy of HIV

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A major goal of HIV-1 research is the development of a new generation of antiretroviral agents that target novel stages of the viral replicative cycle. New agents are needed both to combat the growing incidence of HIV-1 strains that are broadly resistant to existing medications and to reduce the considerable toxicities associated with current therapies. HIV- ...

    SBIR Phase II 2003 Department of Health and Human Services
  7. Development of Hepatitis C Virus Inhibitors

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The development of new therapeutic agents for Hepatitis C virus (HCV) infection is a major public health priority. It is estimated that 170 million people worldwide, including approximately 4 million individuals in the United States, are infected with HCV. Available therapies are non-specific antiviral agents with modest efficacies and significant toxicities. W ...

    SBIR Phase II 2005 Department of Health and Human Services
  8. Broad Detection System for Tick-Borne Pathogens

    SBC: BIOSCIENCE DEVELOPMENT INC            Topic: N/A

    DESCRIPTION (provided by applicant): There is an increasing number of cases and spread of Lyme and other tick-borne diseases in the United States. The same tick that can transmit the agent of Lyme disease, Borrelia burgdorferi, can simultaneously transmit other pathogens such as Babesia, Anaplasma, and Rickettsia. This is of great concern to the public and their physicians. This concern is reflect ...

    SBIR Phase II 2009 Department of Health and Human Services
  9. Minimally Invasive Cardiac Monitor for Neonatal and Pediatric ICU

    SBC: TRANSONIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Currently there exists no technology for routine measurement of cardiac output (CO) in neonates (0.4-2.5Kg) and low weight pediatric (2.5Kg+) patients in the intensive care unit (ICU). Accurate measurement of CO would a llow for better assessment of therapies and thereby improve patient health care. Conventional methods used with adults for routine CO measureme ...

    SBIR Phase II 2008 Department of Health and Human Services
  10. Delivery of Nanoencapsulated TGFbeta and ATRA for the Treatment of IBD

    SBC: THERAPYX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): Phase I studies established proof-of-principle for the efficacy of oral sustained-release TGF?1 (TPX-6001) and ATRA (TPX-7001) nanoparticles in the treatment of IBD in a murine adoptive T-cell transfer model. Specifically, a two-week regimen of oral TPX-6001 and TPX-7001 achieved a 50-90 % reduction in the severity of multiple disease indicators in mice with ad ...

    SBIR Phase II 2011 Department of Health and Human Services

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