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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Molecular Probes for Platelet Heparanase-Digested

    SBC: International Medicine and Biomedical Research            Topic: N/A

    DESCRIPTION (provided by applicant): The project proposed by Agenta Biotechnologies, Inc. will produce diagnostic molecular tools to identify where destructive changes in skin, kidney, heart, eyes, bones, and other organs have occurred. These molecular probes do not exist and would be useful in several medical disciplines. The designed molecular probes may also have potential therapeutic value.

    SBIR Phase I 2006 Department of Health and Human Services
  2. Decoy receptor 3 and liver cirrhosis

    SBC: BIOPOWERTECH            Topic: N/A

    DESCRIPTION (provided by applicant): Liver cirrhosis is a chronic and degenerative disease that can lead to inability of the liver to perform its biochemical function thus severely affecting the quality of patients' life. Currently, liver biopsy is the gold standard in determining the presence of liver cirrhosis. However, liver biopsy is both invasive and costly, with complications. Also, this pro ...

    SBIR Phase I 2006 Department of Health and Human Services
  3. A therapeutic potential of soluble decoy receptor 3 in sepsis

    SBC: BIOPOWERTECH            Topic: N/A

    DESCRIPTION (provided by applicant): Sepsis a serious life-threatening condition resulting from a harmful inflammatory reaction of the body due to bacterial infection. The mortality rate of sepsis remains high in intensive care units around the world but therapeutic interventions have been largely unsuccessful. Clearly, there is a great need for inventing efficacious therapeutic drugs to treat pa ...

    SBIR Phase I 2006 Department of Health and Human Services
  4. Soluble Decoy Receptor 3 in Bacterial Infection and Sepsis

    SBC: BIOPOWERTECH            Topic: N/A

    DESCRIPTION (provided by applicant): Sepsis is a serious inflammatory reaction of the body due to bacterial infection, and the mortality rate of severe sepsis is high in intensive care units around the world. There is a great need for inventing a reliable marker to diagnose patients with sepsis in its early stage so that appropriate therapeutic intervention can be made without delay. We found that ...

    SBIR Phase I 2006 Department of Health and Human Services
  5. Simulation Tool to Rapidly Design, Optimize, and Prototype Microfluidic Devices

    SBC: CFD Research Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): With the increasing use of microfluidics-based technologies in life sciences, the community is challenged with delivering customized and optimized prototypes at low cost and turn-around times. Current simulation- based design tools are computationally expensive (based on 3D multiphysics models) and are more suited for detailed analysis. In addition, conventiona ...

    SBIR Phase I 2006 Department of Health and Human Services
  6. Microfluidic Chip and Software for Microvascular Studies

    SBC: CFD Research Corporation            Topic: N/A

    DESCRIPTION (provided by applicant): Particle adhesion to tissue (vascular endothelium) depends critically upon particle/cell property (size, receptors), scale/geometric features of vasculature (diameter, bifurcation, etc.) and local hemodynamic factors (stress, torque etc). Currently, this is investigated using in-vitro parallel-plate flow chambers which suffer from several serious limitations in ...

    SBIR Phase II 2006 Department of Health and Human Services
  7. Catalyst for promoting analyte derivatization inside a gas-chromatographic inlet

    SBC: CMS FIELD PRODUCTS            Topic: N/A

    DESCRIPTION (provided by applicant): PROJECT SUMMARY: The proposed research will lead to the development of a hardware item, to be inserted into the inlet of a gas chromatograph (GC) that will catalyze "on-line" derivatizations of injected analytes inside the hot GC injection port. Such on-line derivatizations are now being done with the use of conventional glass GC inlet liners and other highly i ...

    SBIR Phase I 2006 Department of Health and Human Services
  8. Acute-infarct selective cardiac MRI contrast agent

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Reliable diagnostic differentiation between acute and chronic myocardial infarcts would be of great benefit for cardiac surgeons and interventional cardiologists. Such differentiation could be used to make decisions about which vessels and in what order would be reopened or bypassed. MRI is an intrinsically noninvasive diagnostic tool and the Delayed Enhancemen ...

    STTR Phase I 2006 Department of Health and Human Services
  9. Persistent Contrast Agent for Percent Infarct Map in MRI

    SBC: ELGAVISH PARAMAGNETICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long term goal of this project is to establish the usefulness of a new infarct-avid, persistent contrast agent (PCA), Gd(ABE-DTTA), which due to its long lifetime in tissue allows construction of accurate relaxation-rate-enhancement(AR1)-based voxel-by-voxel viability maps of the acutely infarcted heart. Assisted by the slow tissue kinetics and infarct-spec ...

    STTR Phase I 2006 Department of Health and Human Services
  10. Expression Profiling of microRNAs with Bead Array

    SBC: GENACO BIOMEDICAL PRODUCTS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of this SBIR application is to develop a bead based array system for the specific detection and classification of microRNAs. The discovery of miRNAs representing a paradigm shift that suggested the existence of many unknown cellular function and regulation mechanisms. Already, miRNAs have been found implicated in different cancers and leukemia. MicroRNA ...

    SBIR Phase II 2006 Department of Health and Human Services

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