Award Data

Project Summary The goal of this Fast Track STTR project is to determine proof-of-principle and efficacy of a novel blood brain barrier (BBB) penetrating therapeutic nanoparticle for the potential treatment of otherwise intractable brain tumors like glioblastoma multiforme (GBM). This project seeks to demonstrate that novel, targetable nanoparticles can delivery therapeutic substances to human bra ...

The goal of this project is to develop a treatment booth with technology that allows opioid treatment programs to remotely dispense, either methadone or buprenorphine, under medical observation through telemedicine to a patient in a treatment booth. We believe that robotic automation is the ideal application to perform the same mechanical functions of the nurse at the dosing window. Specifically, ...

Abstract Pharmacogenomics, the study of how an individual's genetic makeup affects their response to drugs, has undergone rapid advancements. This has occurred alongside a decrease in the cost of genotyping technology, making implementation of pharmacogenomics into clinical practice increasingly feasible. Personalized medicine leveraging pharmacogenomics is gaining momentum to optimize drug choice ...

Project Summary / Abstract DermaXon's project goal is to develop efficacious, substrate-based, selective inhibitors of CYP26s, the enzymes responsible for the metabolism of all-trans retinoic acid (atRA) in the epidermis, as an oral treatment for severe recalcitrant acne. This approach will provide an improved acne therapeutic without the adverse effects associated with currently marketed retinoid ...

This Phase I SBIR will lead to the development of a bandwidth tailored pump source for high purity photon pair generation. Spontaneous parametric down conversion can be used to generate high purity photon pairs at wavelengths of interest to NASA and the broader scientific community. However, these sources are highly dependent on pulsed pump laser parameters. Traditional pulsed laser sources are la ...

This Phase II project aims to prototype a novel technology that can advance the state-of-the-art in high performance space computing.nbsp; The base computer technology, called ldquo;RadPCrdquo;, brings together a suite of fault recovery mechanisms that enable Commercial-off-the-Shelf (COTS) Field Programmable Gate Arrays (FPGAs) to operate reliably in the presence of space radiation that causes si ...

This project proposes a coprocessor companion to future radiation-hardened processors that can boost performance using commercial Field Programmable Gate Arrays (FPGA). nbsp;This project will investigate the feasibility of using dynamically reconfigurable coprocessing circuitry within a proven fault-tolerant architecture known as RadPC.nbsp; The RadPC architecture has been matured through NASA-fun ...

This Phase I SBIR will lead to the development of key photonic components for use in high performance quantum sensors and clocks. AdvR proposes to develop very high performance phase and amplitude modulators for use at visible and ultra-violet wavelengths. The proposed innovation utilizes high performance, damage resistant optical waveguides with high speed traveling wave electrodes to provide int ...

Maintaining healthy populations of salmon and trout (salmonids) has significant biological, cultural, and economic benefits. Significant data gaps exist for sources of mortality in juvenile and adult salmonids in small streams. These gaps can create discrepancies between main stem escapement counts and estimates of population health. Field Data Services, LLC is developing novel camera trap technol ...

The pHyter is a handheld device that accurately measures pH using colorimetry, communicating with a cellphone via Bluetooth Low Energy. The app records location, time, temperature, pH and meta-data. In Phase I, we redesigned the instrument using an ‘internet of things’ development platform, modified the app to operate on both Android and iOS phones, and showed, through a network of partners, t ...