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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Optimization of Supersonic Jet Noise Using a Reynolds-Averaged Navier-Stokes Approach

    SBC: SCIENTIFIC SIMULATIONS            Topic: A1

    The objective of this proposal is the development and demonstration of a cost-effective high-fidelity aeroacoustic design tool for future commercial supersonic nozzle designs and installations. Although eddy-resolving CFD methods for computing high-speed jet noise are available, such methods are computationally expensive and are currently deemed impractical for use in a design optimization loop. ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  2. Integrated Launch Vehicle Booster using a Rocket Engine with a Combined Thermodynamic Cycle

    SBC: FRONTIER ASTRONAUTICS, LLC            Topic: Z9

    The concept describes a booster for a launch vehicle that is simpler to make, transport and launch than current launch vehicles. It is composed of two major components. The first being a booster structure and the second being a liquid rocket engine that uses a thermodynamic cycle that is a combination of two common cycles.Furthermore, the engine is actually fairly simple when compared to modern li ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  3. Optical Line Filter and Spectrometer based Upon Two-Photon Absorption for Doppler LIDAR at 1.053 um

    SBC: ESPYLUX LLC            Topic: S1

    A receiver system for use in LIDAR consisting of an optical filter and optical spectrometer based upon two-photon absorption is proposed. The filter and spectrometer both use dispersion from excited state transitions of atomic rubidium to create a birefringent medium. The birefringent medium of the optical filter rotates the polarization of light so that it is transmitted through crossed polariz ...

    SBIR Phase I 2018 National Aeronautics and Space Administration
  4. Nucleobase aminosugars with reduced ototoxicity

    SBC: NUBAD, LLC            Topic: Y

    PROJECT SUMMARYAminoglycosides are one of the cheapest and well known antibiotics in clinical use for overyearsbut one of the major limitations in their use is their ototoxicityWe are developing fast and low cost methods to develop aminoglycosides with antiribosomal activities and reduced toxicityIn this projectwe will identify novel aminoglycoside antibacterialsthat show reduced ototoxicityComple ...

    STTR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Proteasome inhibitor re-sensitizing molecules for treatment of refractory multiple myeloma

    SBC: Leukogene Therapeutics Inc.            Topic: 102

    Project Summary Abstract Multiple MyelomaMMis the second most common form of blood cancer and remains an incurable and deadly diseaseProteasome inhibitorPItherapy is a cornerstone in the treatment of MMbut resistance to this class of agent is an emerging challenge in the clinicNew therapeutic approaches that specifically target resistance are needed to maximize responses and ultimately produce cur ...

    STTR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  6. A Double Balloon Catheter for the Treatment of Intussusception in Children

    SBC: Sealcath, LLC            Topic: NICHD

    PROJECT SUMMARY ABSTRACT During Phase ISealCathLLC will test the feasibility of its innovative Double Balloon CatheterDBCwhich the United States Utility Patent application was approved on Augustand is in the process of issuing a patentLicensed from the Medical University of South Carolinathis DBC will be commercialized in Phase III as the trademarked nameCephus Catheterwith targeted end users bein ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. A Reliable Switched Angle Spinning (SAS) Probe with Gradients (PFG) for Proteins in Solid-State NMR

    SBC: DOTY SCIENTIFIC, INC.            Topic: 400

    A Reliable Switched Angle SpinningSASProbe with GradientsPFGfor Proteins in Solid State NMR AbstractSolid state NMRssNMRbiotechnology is emerging as an alternative method of choice for highresolution structure determination for integral membrane proteinsIMPsssNMR provides a unique platform to investigate protein dynamicsand functional studies of wide range of biomolecules in their supramolecular a ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Novel therapeutic approach in treatment of glioblastoma using sustained delivery of Connxin43 carboxy-terminal peptide encapsulated in biodegradable nanoparticles in combination with temozolomide

    SBC: FirstString Research, Inc            Topic: 102

    PROJECT SUMMARY GlioblastomaGBMis an incurable cancer even with aggressive therapies such as surgical resection followed by radiotherapy and chemotherapy using temozolomideTMZEfforts to improve surgical resection or the efficacy of irradiation are limited by the potential damage these interventions cause to the brainIn contrastsensitizing GBM to TMZ is an appealing strategy because TMZ has excelle ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  9. Targeted Nanotherapy to Donor Organ Endothelia Modulates Early Immune Responses and Protects Against Late Graft Failure

    SBC: ToleRaM NanoTech LLC            Topic: NIBIB

    ABSTRACT Transplantation is an accepted and highly successful therapy for end stage organ diseaseWhile success rates and survival have risen steadilydue largely to improved immunosuppression regimesthere is a growing appreciation that damage and inflammation that occur early in the life of the graftsignificantly impact chronic rejection and thus long term survivalCentral to these early event injur ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Construction and testing of a rabbit cornea-equivalent for evaluation of chemical injury in vitro

    SBC: TISSUE TESTING TECHNOLOGIES LLC            Topic: NIEHS

    ABSTRACTWe propose combination of the rabbit cornea endothelial and epithelial cells with bioengineered scaffolds in cell culture well insertsThis technology could significantly reduce the use of rabbits for the Draize rabbit eye irritation assayThe barrier to commercialization is the lack of an effective method for storingbankingof living bioengineered cornea equivalentsWe will combine cell expan ...

    SBIR Phase I 2018 Department of Health and Human Services
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