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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IGF OT IGF DEVELOPMENT OF AN INNOVATIVE PSMA TARGETED RADIONUCLIDE THERAPY FOR PROSTATE CANCER PERIOD OF PERFORMANCE

    SBC: CANCER TARGETED TECHNOLOGY LLC            Topic: NCI

    Background Information The Phase II of the contract has four objectives Objective Scale up and analytical characterization of the lead radiotherapeutic agent selected from Phase I Objective Optimization of dose regimen in an animal efficacy model using a PSMA expressing subcutaneous human prostate tumor Objective Maximum Tolerate Dose Study of Lead Lu DOTA PSMA therapeutic agent ...

    SBIR Phase I 2015 Department of Health and Human Services
  2. SYSTEMIC RADIONUCLIDE THERAPY TARGETED TO VEGF RECEPTORS IN TUMOR VASCULATURE

    SBC: SIBTECH, INC.            Topic: NCI

    The overall goal of this collaborative project between SibTech Inc PI Backer J and Johns Hopkins University PI Pomper M is clinical development of efficient and cost effective anti angiogenic Lu radiopharmaceutical scV Lu for VEGF receptor mediated targeting of angiogenic tumor vasculature Current very expensive anti angiogenic compounds induce transient regression of tumor vascula ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  3. IGF OT IGF Topic Phase I SBIR Predictive Biomarkers of Adverse Reactions to Prostate Cancer Radiotherapy

    SBC: L2 DIAGNOSTICS, LLC            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  4. IGF OT IGF Topic Phase I SBIR Defining normal tissue and tumor biomarkers of radiosenstivity to detect treatment

    SBC: MIRA DX, Inc.            Topic: NCI

    Not Available

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  5. IGF OT IGF SBIR PHASE II TOPIC TITLE A VASCULARIZED TUMOR MICROENVIRONMENT ASSAY FOR THE SCREENING OF ANTI CANCER DRUGS

    SBC: Nortis, Inc.            Topic: NCI

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  6. IGF OT IGF INHALED DRUG COMBINATION FOR TUBERCULOSIS THERAPY

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    Not Available

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Engineering a phosphotyrosyl-tRNA Synthetase

    SBC: AXIOMX INC            Topic: 300

    DESCRIPTION provided by applicant Although tyrosine phosphorylation is an important controlling element in cell signaling no tRNA suppressor for phosphotyrosine pTyr incorporation has yet been made We propose to use directed molecular evolution of several aminoacyl tRNA synthetases aaRSs to identify mutations that enable binding of pTyr to the aaRS Specifically ATP molecules will be att ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Real-time myoglobin saturation measurement to assess benefit of RBC transfusion

    SBC: Opticyte, Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Critically ill patients commonly arrive at an intensive care unit with anemia While blood transfusions are the standard of care with the intention to increase or maintain oxygen delivery to tissues questions have been raised about the benefit of blood transfusions particularly in non bleeding patients with moderate anemia A noninvasive measure of intracellu ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Measuring toxicant effects on cellular function in a microarray format

    SBC: CIENCIA INC            Topic: NIEHS

    DESCRIPTION provided by applicant The EPA maintains a Toxics Release Inventory of over toxic chemicals that are disposed or released from more than industrial sites in the United States The Department of Health and Human Services and USDA maintain a list of over select agents and toxins that pose a severe risk to both human animal and plant health These compounds represent only ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  10. A DOPPLER SIMULATOR FOR VASCULAR ULTRASOUND TRAINING

    SBC: Sheehan Medical LLC            Topic: NIBIB

    DESCRIPTION provided by applicant Doppler ultrasound is relied upon as the primary and often the only test used to diagnose vascular pathology Because variations in technical skill directly impact surgical referral decisions there is a strong clinical need to ensure that provides both attain and maintain skills in this procedure The problem we address is the lack of a quantitative or standar ...

    STTR Phase II 2015 Department of Health and Human Services

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