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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Adherence Monitor for Substance Use Disorder Treatment

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIDA

    Project Summary The focus of the present SBIR program is to determine the feasibility of a new noninvasivepoint of care testing device for patients undergoing treatment for substance use disorderThe new device will be capable of monitoring the progress and verifying adherence with patient treatment regimen by detecting the presenceand levelof a compounded adherence marker released in the urineprov ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Topical selective T-type blockers for the treatment of neuropathic pain

    SBC: Dermaxon LLC            Topic: 105

    Project SummaryAbstract Paclitaxel is widely used throughout the field of oncology with indications for the treatment of a number of solid tumorsThe most commonly reported neurotoxic effect of paclitaxel is peripheral sensory neuropathy which often limits the dose and frequency of paclitaxel treatmentNeuropathic pain management is currently aimed only at reducing symptoms and treatment of chronic ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Integrating CNV analysis into a NextGen sequencing clinical analytics platform

    SBC: Golden Helix, Inc.            Topic: 400

    Abstract The goal of this project is to develop a commercial analysis software platform that features the ability to detect and interpret copy number variantsCNVsand other types of structural variationsSVsfrom short read NextGen SequenceNGSdata to enable comprehensivewidely accessibleand economical genetic testingThis capability is key in clinical and research applicationsFor examplecurrently clin ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Improving STEM learning through digital technology simulating authentic research

    SBC: MEADOWLARK SCIENCE AND EDUCATION, LLC            Topic: 500

    Novel and effective techniques for imparting STEM based knowledge and concepts are increasingly in demand as our world becomes progressively computerized and complexWhile traditional teaching approaches have worked well in the past for many areas of studyresearch has shown that traditional teaching methods may diminish student engagement in scientific studieswhich are especially dynamic and consta ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Selective inhibition of CYP26A1 in the skin for the treatment of ichthyosis

    SBC: Dermaxon LLC            Topic: NIAMS

    Project SummaryAbstract DermaXon s project goal is to develop efficacious substrate based and highly selective inhibitors of CYPsthe enzymes responsible or retinoic acidRAmetabolism in the epidermisfor the topical treatment of ichthyosisThis approach will provide a therapeutic advantage in ichthyosis without the potential adverse effects mediated by non targeted Pinhibitionassociated with previous ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. Live Cell Assays to Identify and Interrogate Stressed Neurons in Models of Neurodegenerative Disease.

    SBC: Montana Molecular LLC            Topic: 105

    Summary Abstract Many diseases of the brain involve cellular stressEarly in lifethe Zika virus triggers stress in neural progenitor cells causing microcephalyMuch later in life the mutant proteins produced in Parkinsonandapos s and Huntingtonandapos s diseaseas well as ALSand Alzheimerandapos s all produce cellular stress leading to the slow neurodegeneration that occurs over many yearsTypically t ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. NV103: Antibody Conjugated Nanoparticle for Ewing Sarcoma Targeted Therapy

    SBC: NanoValent Pharmaceuticals, Inc.            Topic: 102

    Project Summary This Phase II SBIR project seeks to demonstrate that noveltargetable nanoparticles can delivery therapeutic substances to human tumor cells and reduce tumor burden in cancerThe concept for these nanoparticles is based on the hybrid polymerized liposome nanoparticleHPLNthat displays functional antibodies that target tumor cell surface markersThe therapeutic cargos are encapsulated c ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. GUANIDINIUM DERIVATIVES FOR THE TREATMENT OF OCULAR PAIN

    SBC: SITEONE THERAPEUTICS, INC.            Topic: N

    PROJECT SUMMARY The absence of safe and effective strategies for the management of ocular pain is motivating the development of a novel topical drug suitable for patient self administrationConventional local anestheticssuch as proparacaineinhibit voltage gated Naion channelsNaVand are highly effective for the management of ocular pain in acutein office settingsHoweverthese agents are short acting ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Targeted Polymerized Shell Microbubbles to Image and Treat Surgical Adhesions

    SBC: NanoValent Pharmaceuticals, Inc.            Topic: 300

    Project Summary The long term goal of this Phase II SBIR project is to develop a commercially viable ultrasound contrast reagentUCRthat will allow the noninvasive identification and treatment of newly forming abdominal adhesions after surgerySuccessful implementation would have significant impact because we would both improve patient post surgical monitoring and considerably reduce the cost of adh ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Single application thixotropic antibiotic delivery systems for otitis externa

    SBC: Promiliad Biopharma Incorporated            Topic: NIDCD

    The proposal seeks to initiate the development of a tetraethyl orthosilicate based thixotropic antibiotic delivery systems for the treatment of otitis externa and prevention of malignant otitis externaThis study will set the foundation for the development of point of caresingle application thixotropic drug delivery platform technologies for otic therapeutics PROJECT SUMMARY Outer ear infectionsoti ...

    STTR Phase I 2018 Department of Health and Human Services

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