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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. The Bimodal Ankle: Development and Engineering Validation of a Hydraulic Actuator

    SBC: OHIO WILLOW WOOD COMPANY, THE            Topic: na

    This project designs, fabricates, and completes engineering verification of a hydraulic actuator for a novel prosthetic ankle-foot system. The goal of this project is to improve balance and balance confidence of persons with lower extremity amputations by developing a prosthetic ankle that has biomimetic modes for walking and standing. This bimodal ankle provides flexibility for walking mobility a ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Rapid response toxicology prediction platform

    SBC: LEADSCOPE, INC.            Topic: NIEHS

    Project Summary Abstract In silico toxicology is an important alternative approach to animal testing that provides a fast and inexpensive prediction of toxicityIt uses computer models to predict whether a chemical is safe or if there is a potential hazardIn silico methods are particularly valuable when a decision needs to be made quicklysuch as for an emergency response to a chemical spill or when ...

    SBIR Phase II 2018 Department of Health and Human Services
  3. Development and validation of a novel non-invasive device for measuring the mechanical properties of cortical bone

    SBC: AEIOU Scientific LLC            Topic: NIA

    Abstract AEIOU ScientificLLCAEIOUaims to develop and commercialize Ohio Universityandapos sOHIOandapos spatent pending Cortical Bone Mechanics TechnologyCBMTas a non invasive medical device for improving the diagnosis and monitoring of osteoporosis and other bone diseasesOsteoporosis and low bone mass affectmillion Americans andmillion people worldwideIn womenthe resulting fragility fractures caus ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Humanized EMAP II mAb as a Novel Therapy for Viral-Associated Lung Injury

    SBC: Allinaire Therapeutics, LLC            Topic: NHLBI

    Summary Abstract The ultimate goal of this project is the validation of a humanized endothelial monocyteactivating protein IIEMAP IIneutralizing monoclonal antibodymAbfor progression to clinical evaluation as a novel treatment for patients with influenza associated lung injuryInfection with influenza virusIAVremains a major world wide health threat to high risk populations including the young and ...

    STTR Phase I 2018 Department of Health and Human Services
  5. 3D Holographic Guidance, Navigation, and Control (3D GN&C) for Endovascular Aortic Repair (EVAR)

    SBC: Centerline Biomedical, Inc.            Topic: NHLBI

    Project Summary This project will develop newD visualization to improve stent graft deployment during minimally invasive endovascular aortic repairEVARby overcoming limitations ofD x ray fluoroscopyfluoroD holographic guidancenavigation and controlD GNandamp Cwill be provided to decrease fluoro radiation dose burden to patients and OR staff during treatment of aortic aneurysmsparticularly when dep ...

    STTR Phase I 2018 Department of Health and Human Services
  6. Enzymatic attachment of proteins to fluorescent nanodiamond surfaces.

    SBC: COLUMBUS NANOWORKS, INC.            Topic: 400

    Fluorescent nanodiamonds are biocompatibleinfinitely photostableand fluoresce in a variety of wavelengthsincluding the near infraredNIRregionThese characteristics suggest transformative applications in areas ranging from pure biological research to biomedical imagingwhere protein conjugated nanodiamonds could be targeted to specific tissues in living patients or even structures within individual c ...

    STTR Phase I 2018 Department of Health and Human Services
  7. Off-the-Shelf Patch for Repairing Tracheal Stenosis

    SBC: Nanofiber Solutions, Inc.            Topic: NHLBI

    PROJECT SUMMARYThe long term objective of this application is to bring a trachea patch to the market to treat tracheal stenosisor narrowing of the airwaywhich left untreated is a life threatening condition that affects both young children and adultsCurrentlyotolaryngologists have only two major options for treating tracheal stenosisOne is a complex surgical procedure known as slide tracheoplasty t ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A Novel, Non-Cytotoxic, Epigenetic Therapeutic for Sickle Cell Disease

    SBC: DeNovoTherapies LLC            Topic: NHLBI

    ABSTRACT The goal of this Fast Track proposal is to develop a novel non cytotoxicepigenetic therapeutic for life long disease modification of sickle cell diseaseSCDSCD is a morbidlife shortening condition caused by mutated hemoglobinsickle hemoglobinHbSThe pathophysiology triggered by sickle hemoglobin is interrupted by another hemoglobin that the body usually produces in uterofetal hemoglobinHbFT ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Targeted LystaMab Therapy to Optimize Tissue Engineered Vascular Graft Performance

    SBC: Lyst Therapeutics LLC            Topic: NHLBI

    Project Description Despite significant advances in the surgical and medical management of congenital heart diseasecongenital cardiac anomalies remain a leading cause of death in the newborn periodMost severe forms of congenital heart disease require surgical interventionComplications arising from the use of currently available prosthetic materials in the form of vascular graftspatchesor replaceme ...

    STTR Phase I 2018 Department of Health and Human Services
  10. Testing and Commercialization of a Superior Device to Maintain Perioperative Normothermia In Anesthetized Patients

    SBC: Mercury Biomed LLC            Topic: 300

    Project SummaryAbstractThis proposal presents Phase II of Mercury Biomedandapos s plan for commercializing the new and innovative WarmSmart technology to more effectively keep surgical patients normothermicWarmSmart embodies several breakthrough concepts in bioheat transfer to manage core temperatureWe are building a costcompetitive patient warming technology that will be superior to existing tech ...

    STTR Phase II 2018 Department of Health and Human Services

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