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INTRACELLULAR CALCIUM CONCENTRATION IS KNOWN TO PLAY A SIGNIFICANT ROLE IN BOTH PHYSIOLOGICAL AND PATHOPHYSIOLOGICAL CONDITIONS. RECENTLY, MUCH ATTENTION HASBEEN GIVEN TO THE DETERMINATION OF FREE INTRACELLULAR CALCIUM CONCENTRATION USING FLOW CYTOMETRY. NEWLY DEVELOPEDFLUORESCENT PROBES, SUCH AS INDO-1 WHICH EXHIBITS A LARGE SPECTRAL EMISSION SHIFT WHEN IT CHELATES CA(++) IONS, HAVE BEEN INSTRUME ...

BECAUSE OF ITS COMPLEXITY, THE STUDY OF THE NATION'S NATURALGAS SELF- SUFFICIENCY REQUIRES A REGIONAL APPROACH. BEFORE SELF-SUFFICIENCY CAN BE EMPIRICALLY ANALYZED, IT IS NECESSARY TO DELINEATE THE REGIONAL FACTORS INVOLVED. THE OBJECTIVE OF THIS RESEARCH IS TO ASSESS THE POTENTIAL FOR NATURAL GAS SELF-SUFFICIENCY ON A NATIONAL LEVEL THROUGH STATE AND REGIONAL SUCCESSES. THIS PROJECT WILL ASSESS T ...

PERSONNEL WORKING IN EXTREME ENVIRONMENTS OR WEARING BALLISTIC AND/OR NUCLEAR/BIOLOGICAL/CHEMICAL (NBC) PROTECTIVE CLOTHING ARE SUBJECT TO THE HAZARDS OF OVERHEATING. THESE HAZARDS INCLUDE PHYSICAL DISCOMFORT, DECREASED PHYSICAL AND MENTAL ABILITIES, DEHYDRATION, AND EVENTUALLY DEATH FROM HEAT STRESS. THE NUMBER OF PERSONNEL VULNERABLE TO THESE HAZARDS IS ALREADY QUITE LARGE AND IS STEADILY INCREA ...

THIS RESEARCH AND DEVELOPMENT EFFORT IS AIMED TOWARD THE VALIDATION AND USE OF A PORTABLE BIOCHEMICAL DETECTOR ("C-PROBE") AS AN INDICATOR FOR HUMAN EXPOSURES TO CARCINOGENIC CHEMICAL AGENTS IN THE FIELD. DURING PHASE I, C-PROBE RESPONSES TO TEST AGENTS WILL BE COMPARED WITH IN VITRO AND IN VIVO PRODUCTION OF CARCINOGEN-DNA ADDUCTS THAT FORM AS A RESULT OF THE EXPOSURES. SUCCESSFUL COMPLETION OF P ...