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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. IGF::OT::IGF SBIR TOPIC 379: DIGIBIOMARC: DIGITAL BIOMARKERS FOR CLINICAL IMPACT- MOONSHOT PROJECT(FAST TRACK)

    SBC: Medable Inc.            Topic: NCI

    The overall objective of this Fast Track SBIR contract project is to develop DigiBioMarCTMDigital BioMarkers for Clinical Impacta scalable and flexible cloud based platform to capture and analyze wearableimplantableor external device dataThis platform also provides an informatics tool for automated data aggregationintegrationand machine learning algorithmsIt is based on the scalable user centered ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Structure-based discovery of dopamine D1 receptor selective small molecule ligands

    SBC: CONFOMETRX, INC.            Topic: 101

    Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Reclaiming Employment: Self-Employment Resources for Mental Health Service Users

    SBC: Live and Learn Society            Topic: NA

    This project designs and develops, Reclaiming Employment, an online capacity-building program for individuals with psychiatric disabilities that aims to improve self-sufficiency and empowerment through entrepreneurship. The product targets employment outcomes at two stages of self-employment: increased competencies for individuals with psychiatric disabilities who wish to become self-employed; and ...

    SBIR Phase I 2019 Department of Health and Human ServicesAdministration for Community Living
  4. A Personalized Wheelchair Fitting System to Improve Function and Quality of Life

    SBC: Kinetic Intelligence, LLC            Topic: NA

    The goal of this project is to confirm that informatics generated using the commercial version of the System for Personalizing and Evaluating the Fit of Assistive Devices in a Clinical Setting (SPEC) system, designed for clinicians by clinicians, can seamlessly integrate data into an Integrated Informatics System (IIS) database module for wheelchair fitting. The objectives are to: (1) verify that ...

    SBIR Phase I 2019 Department of Health and Human ServicesAdministration for Community Living
  5. DEVELOPMENT OF NOVEL PDE4B INHIBITORS TO TREAT ALCOHOL USE DISORDER (SBIR PHASE II)

    SBC: CODEX BIOSOLUTIONS            Topic: NIAAA

    Development of Novel PDE B Inhibitors to Treat Alcohol Use Disorder

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A point of care test for TB antibiotic concentration in blood

    SBC: NANOCOMPOSIX, INC.            Topic: NIAID

    TuberculosisTBis one of the topcauses of death worldwideTB treatments include combinations of multiple antibiotics and dosage levels over a long period of timeOften the dose must be adjustedLow antibiotic blood concentrations may cause slow responseprolonged infection or treatment failureand the TB strain may acquire drug resistancetoo high and toxicity may be an issueCurrent technologies for meas ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. POC Diagnostic for Gonorrhea and Determination of Antimicrobial Susceptibility

    SBC: Visby Medical, Inc.            Topic: NIAID

    VisbyFormally know as Click Diagnosticshas developed a PCR based rapiddisposablepoint of care test that automatically performs sample processingPCR amplificationand amplicon detectionLeveraging the existing platformClick willfrom a single urogenital sampledetect NG and determine whether the infecting strain is susceptible to three classes of antibioticsciprofloxacincefiximeor a novel antibiotic zo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. New Carriers Used as Adjuvants for Controlled HIV Immunogen Delivery into Targeted Antigen Presenting Cells

    SBC: NANOCOMPOSIX, INC.            Topic: NIAID

    Despite the global impacts of HIV on human healthwith an estimatedmillion new cases each year andmillion people living with HIVan effective vaccine has not been developedThere are many challenges for HIV vaccine development including the virus s rapidly changing surface immunogens and the early integration of the virus into the host s genomeTo overcome these challengesa mesoporous silica adjuvant ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Mobile Health Point-of-Care Diaagnostics for Malaria

    SBC: Chromologic LLC            Topic: NIAID

    A resurgence of malaria infections has occurred in the USprimarily due to increasing global travelOnly wide spread screenings and treatments of endemic populations can prevent the return of malaria endemicityCurrentlythere is no diagnostic test that meets the need of highly sensitive malaria screening tool for low resource settingsTo address this needChromoLogic proposes to develop the Quick Mag p ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Evaluation of VesiVax Adjuvant Formulations for HIV Vaccines

    SBC: Molecular Express Inc            Topic: NIAID

    This proposal aim to develop a VesiVaxplatform based liposomal vaccine that can co formulate the HIV antigenHIV Env gpAwith various immunotimulatory adjuvant moleculesIAMsThe IAMs that we will formulate with the antigen includeslipidated tucaresolmuramyl tripeptide phosphatidylethanolaminePam CAGmonophosphoryl lipid AdsRNAandcyclic dinucleotidesThe formulations will be evaluated in miceand selecte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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