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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Gap-Free Model-Based Engineering for Manufacturing and Analysis: Digital Thread without Translation

    SBC: Nvariate, Inc.            Topic: None

    Modern Model-Based Enterprise / Engineering (MBE) systems rely on freeform surfaces built as complex combinations of geometric primitives to define engineered objects. Unfortunately, the intersection of freeform surfaces in MBE applications results in highly approximated solutions, degrading models that cost billions annually by US industry to fix. Current technology limits the abilities of users ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  2. Advanced Manufacturing and Material Measurements Software Tool Weave ™ for the Acceleration and Automation of SEM Image Analysis in the Semiconductor Industry

    SBC: Sandbox Semiconductor Incorporated            Topic: None

    In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. Multimode Chiroptical Spectrometer for Nanoparticle Characterization

    SBC: Applied Nanofluorescence LLC            Topic: None

    This project will develop a new scientific instrument optimized for the advanced characterization of near-infrared fluorescent nanoparticles that can exist as left- or right-handed structures (enantiomers). Single-walled carbon nanotubes (SWCNTs) are the leading current example of such nanomaterials. Applied NanoFluorescence, LLC (ANF) proposes a novel multi-mode chiroptical spectrometer that can ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  4. Development of an anti-bias caster system

    SBC: ACCESSIBLE DESIGNS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The importance of reducing the incidence of secondary injuries related to manual wheelchair propulsion is undisputed. Based on several research studies, approximately 50% of manual wheelchair users (MWU) report symptoms of repetitive strain injury (RSI) related to the demand on the upper extremity during propulsion and transferring tasks. A substantial effort ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. X

    SBC: Altor Bioscience LLC            Topic: N/A

    X

    SBIR Phase II 2010 Department of Health and Human Services
  6. New Reagents for Synthesis of High Potency siRNA

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): New Reagents for Synthesis of High Potency siRNAs Abstract Since the discovery of short interfering RNA (siRNA) molecules in the late 1990s, siRNA technology has developed rapidly as a powerful tool for functional genomic analysis, target validation and therapeutic purposes. However, the potency and persistence of unmodified siRNAs is dramatically limited by th ...

    SBIR Phase II 2010 Department of Health and Human Services
  7. THIOAPTAMER CAPTURE FOR ADDICTION-RELEVANT PROTEINS

    SBC: AM BIOTECHNOLOGIES, LLC            Topic: NIDA

    AM Biotechnologies (AM) will develop renewable thioaptamer protein capture reagents to ten proteins related to drug addiction. Thioaptamers are a type of aptamer containing phosphorodithioate linkages and other modifications that have excellent affinity and specificity for proteins. Because of the unique chemical composition of thioaptamers, they cannot be developed using the Systematic Evolution ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Identification of microRNA Biomarkers for Colon Cancer Recurrence Risk Stratifica

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): The current primary form of treatment for all stages of colon cancer is surgical resection, with overall survival rates depending upon whether the cancer recurs and metastasizes. The likelihood of recurrence is directly related to the stage of cancer, which is determined by the depth of tumor penetration into the wall of the colon. Recurrence rates range from 2 ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Technologies for mapping interspersed AGG sequences in the FMR1 gene

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The objective of this project is to develop a comprehensive set of assays to improve screening and prediction of conditions associated with fragile X syndrome (FXS). FXS, which affects approximately 1/4000 men and 1/6000 women, is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 52 untranslated region (UTR) of the FMR1 gene. The ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Amplification Strategies for Detection of Fragile X Gene Trinucleotide Repeats

    SBC: AMBION DIAGNOSTICS, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall objective for this project is to develop and implement a comprehensive set of technologies to improve screening and diagnosis of conditions associated with Fragile X Syndrome (FXS). FXS is caused by an expansion of a cytosine-guanine-guanine (CGG) triplet repeat in the 5'-untranslated region of the FMR1 gene. FXS affects 1/4000 men and 1/6000 wo ...

    SBIR Phase II 2010 Department of Health and Human Services

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