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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. A Personalized Wheelchair Fitting System to Improve Function and Quality of Life

    SBC: Kinetic Intelligence, LLC            Topic: NA

    The goal of this project is to confirm that informatics generated using the commercial version of the System for Personalizing and Evaluating the Fit of Assistive Devices in a Clinical Setting (SPEC) system, designed for clinicians by clinicians, can seamlessly integrate data into an Integrated Informatics System (IIS) database module for wheelchair fitting. The objectives are to: (1) verify that ...

    SBIR Phase I 2019 Department of Health and Human Services
  2. POC Diagnostic for Gonorrhea and Determination of Antimicrobial Susceptibility

    SBC: Visby Medical, Inc.            Topic: NIAID

    VisbyFormally know as Click Diagnosticshas developed a PCR based rapiddisposablepoint of care test that automatically performs sample processingPCR amplificationand amplicon detectionLeveraging the existing platformClick willfrom a single urogenital sampledetect NG and determine whether the infecting strain is susceptible to three classes of antibioticsciprofloxacincefiximeor a novel antibiotic zo ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Rapid Point-of-Care Tests to Simultaneously Quantify Anti-TB Drugs in Blood

    SBC: Zymeron Corporation            Topic: NIAID

    TuberculosisTBis currently the leading infectious cause of death worldwideTB treatment includes multiple different combinations of antibioticsdosesand long time periodsThe current standard includes an intensive phase ofmonthsfollowed by a continuation phase of eitherormonthsHowevertreatment outcome can be poor due to drug drug interactionsimpaired medication adherencedrug absorption and metabolism ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Mobile Health Point-of-Care Diaagnostics for Malaria

    SBC: Chromologic LLC            Topic: NIAID

    A resurgence of malaria infections has occurred in the USprimarily due to increasing global travelOnly wide spread screenings and treatments of endemic populations can prevent the return of malaria endemicityCurrentlythere is no diagnostic test that meets the need of highly sensitive malaria screening tool for low resource settingsTo address this needChromoLogic proposes to develop the Quick Mag p ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. In Vivo Targeted Degradation of HIV Gag Polyprotein by Gag-PROTAC Reagents

    SBC: Zymeron Corporation            Topic: NIAID

    HIV disease continues to be a serious health issue for the whole worldCurrentlyantiretroviral therapyARTis a widely accepted treatment to HIV infected patientswhich reduces morbidity and mortality and the potential for HIV transmission by suppressing viral replicationHowevertreatment outcomes of ART are limited due to the high adherence requirement and occurrence of drug resistanceProteolysis targ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Evaluation of VesiVax Adjuvant Formulations for HIV Vaccines

    SBC: Molecular Express Inc            Topic: NIAID

    This proposal aim to develop a VesiVaxplatform based liposomal vaccine that can co formulate the HIV antigenHIV Env gpAwith various immunotimulatory adjuvant moleculesIAMsThe IAMs that we will formulate with the antigen includeslipidated tucaresolmuramyl tripeptide phosphatidylethanolaminePam CAGmonophosphoryl lipid AdsRNAandcyclic dinucleotidesThe formulations will be evaluated in miceand selecte ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. A smartphone-based point-of-care test for detection of influenza in low resource settings

    SBC: Luminostics, Inc.            Topic: NIAID

    Each yearinfluenza causes more thanhospitalizations and aboutdeaths in the U SPeriodicallypandemic strains of influenza emerge that cause even greater devastationthe most recent H Npandemic ofcausingdeaths in the U SDiagnostic testing for influenza is a critical component in managing the diseaseit offers data used in global influenza surveillance efforts and can help guide the treatment of individ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. A Rapid Nucleic Acid Test for the Point of Care Detection of Malaria

    SBC: Crosslife Technologies Inc.            Topic: NIAID

    We propose the development of a highly sensitivesimple paper strip molecular nucleic acid blood test that detects parasites causing malaria at the point of careThe final product to be developed in Phaseis an FDA approved nucleic acid based diagnostic device paper dipstick test that contains a multiplex of probe that can amplify and detect nucleic acid sequences from the gametocyte specific pfstran ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid Point-of-Care Diagnostics to Detect Serologic Status of Individuals for Select Viral Infections

    SBC: Zymeron Corporation            Topic: NIAID

    CytomegalovirusCMVis a very common intrauterine infectionaffecting approximately one in everychildrenThe overall disease burden in the US with congenital CMV was estimated at $billion annuallyCMV is also a cause of serious morbidity and fatal infections in immunocompromised patientsThere is currently no generally accepted therapy and developing a CMV vaccine is high priorityCurrently CMV trials re ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. EAP-Derived Monoclonal Antibodies or Phenotyping Immune Cells of Animal Models of Disease

    SBC: SILVER LAKE RESEARCH CORPORATION            Topic: NIAID

    The investigation of mechanismspotential treatmentsand vaccines for infectious diseases relies on animal models that can be infected by the same agent as humans and display similar symptomsIn many casessuch animals are not the typicalwell characterized research modelsbut rather non traditional speciesOne example of this situation is the ferret model of influenzaA major drawback of non traditional ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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