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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ASSAY FOR PREDICTING METHOTREXATE SENSITIVITY IN HUMAN BREAST CANCER

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTION OF THERAPIES FOR INDIVD- UAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHO- TREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DE-TERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FORFOR FEEDER LAYERS AND MEDIUM COMPONENTS THAT CAN RESCUE SEN-SITIVE CELLS. THIS PROPOSA WILL,THEREFORE, EVAL ...

    SBIR Phase II 1987 Department of Health and Human Services
  2. AN IMAGE PREPARATION AND PRESENTATION SYSTEM FOR PSYCHOBIOLOGY

    SBC: American Innovision, Inc.            Topic: N/A

    NEWLY AVAILABLE TECHNOLOGY MAKES IT POSSIBLE TO CONSTRUCT VIDEO-BASED DEVICES FOR PREPARING AND PRESENTING VIDEO IMAGES THAT INCORPORATE FUNCTIONS OF MANY DIFFERENT TYPES OFIMAGE PRESENTATION SYSTEMS CURRENTLY IN USE IN LEARNING, BEHAVIOR, AND VISION RESEARCH. THE IMAGE EDITOR WOULD INCLUDE THE CAPACITY TO TAKE SELECTED PORTIONS OF VIDEO IMAGES AND REARRANGE THEM AS DESIRED TO CREATE A STIMULUS IM ...

    SBIR Phase II 1987 Department of Health and Human Services
  3. MICROCOMPUTER DISPLAY MAGNIFICATION FOR LOW-VISION USERS

    SBC: Berkeley Systems Inc            Topic: N/A

    THIS IS A PROPOSAL FOR THE DEVELOPMENT OF AN INEXPENSIVE SOFTWARE ACCESSORY WHICH ENHANCES MICROCOMPUTER ACCESS FOR THE PARTIALLY SIGHTED. THE SOFTWARE MAGNIFIES SELECTED PORTIONS OF A COMPUTER SCREEN, ENABLING A PERSON WITH LOW VISUAL ACUITY TO USE STANDARD PERSONAL COMPUTERS AND SOFTWARE PACKAGES WITHOUT SPECIAL EQUIPMENT OR MODIFICATIONS. BY MAKING STANDARD PRODUCTS AVAILABLE, THIS APPROACH CRE ...

    SBIR Phase II 1987 Department of Health and Human Services
  4. NONINVASIVE IMAGING OF REGIONAL BRAIN BLOOD FLOW

    SBC: Biocomp Systems Inc.            Topic: N/A

    ACCURATE, NONINVASIVE ASSESSMENT OF BRAIN CIRCULATION IS NEEDED IN NUMEROUS NEUROSURGICAL PROCEDURES, CLINICAL DIAGNOSIS OF CEREBROVASCULAR PATHOLOGY (E.G., STROKE), DRUG TESTING, AND BIOLOGICAL PSYCHIATRY. HOWEVER, CURRENTLY EMPLOYED METHODS NOT ONLY ARE VERY COSTLY, BUT EXPOSE PATIENTS TO RADIOACTIVE MATERIALS. FURTHER, NO AVAILABLE METHODS PROVIDE SECOND-TO-SECOND (E.G., REAL-TIME) DYNAMIC MEAS ...

    SBIR Phase II 1987 Department of Health and Human Services
  5. REGULATION OF BIOLOGICAL GROWTH

    SBC: Biogrowth Inc.            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO BE ABLE TO REGULATE ABNORMAL GROWTH PROCESSES THAT ARE RELATED TO SOMATOMEDINS. AS SOMATOMEDINS ARE THE MAJOR STIMULATORS OF BONE FORMATION, THEY OFFER PROMISE IN THE THERAPY OF POST- MENOPAUSAL OSTEOPOROSIS. THEY MAY ALSO BE USED TO STIMULATEBONE FORMATION AROUND PROSTHETIC JOINTS. THE STIMULATORY PROPERTIES OF SOMATOMEDINS MAY ALSO BE IMPORTANT IN HA ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. RAPID, ACCURATE IDENTIFICATION OF NON-FERMENTERS (NEGNB)

    SBC: BIOLOG, INC.            Topic: N/A

    APPROXIMATELY 15% OF BACTERIAL INFECTIONS ARE CAUSED BY NON-ENTEROBACTERIACEAE GRAM-NEGATIVE BACILLI. THIS IS AN EXTREMELY HETEROGENEOUS GROUP OF BACTERIA, AND PRESENT SPECIATION METHODS ARE VERY UNSATISFACTORY. BIOLOG HOLDS TWO PATENTS ON A NEW REDOX METHOD OF TESTING WHICH CAN BE DEVELOPED INTO IDENTIFICATION TESTS FOR ALL CLINICALLY IMPORTANT MICROORGANISMS. THESE TESTS WILL IDENTIFY AN ORGANIS ...

    SBIR Phase II 1987 Department of Health and Human Services
  7. INFORMATION RESOURCE ACTIVITIES IN CHEMOPREVENTION LITERA- TURE

    SBC: Ccs Associates            Topic: N/A

    THE OBJECTIVE OF THIS PROJECT IS THE DEVELOPMENT OF A COMPREHENSIVE INFORMATION RESOURCE ON CHEMOPREVENTION THAT MAY BE APPLIED TO THE IDENTIFICATION OF CHEMOPREVENTIVE AGENTS AND TO OTHER RESEARCH AND DEVELOPMENT PROBLEMS IN CHEMOPREVENTIOTHE DEVELOPMENT OF CHEMOPREVENTIVE AGENTS IS A HIGH-PRIORITYRESEARCH EFFORT AT NCI, PARTICULARLY FOR AGENTS THAT ARE EF-FICACIOUS AND SAFE FOR USE IN PATIENTS A ...

    SBIR Phase II 1987 Department of Health and Human Services
  8. GENETIC ENGINEERING APPROACHES FOR AIDS VACCINES (MICE, RABB

    SBC: Chiron Corp            Topic: N/A

    WE HAVE MOLECULARLY CLONED, SEQUENCED, AND EXPRESSED THE GENES OF THE RETROVIRUS ASSOCIATED WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME (AIDS), AND WE HAVE INITIATED GENETIC ENGINEERING APPROACHES FOR THE DEVELOPMENT AND TESTING OF SUBUNIT VIRAL VACCINES. THE PREDICTED SEQUENCE OF THE VIRAL ENVELOPE (ENV) PROTEIN HAS BEEN USED TO DESIGN SYNTHETIC PEPTIDES, AND THE ENTIRE ENV GENE AND VARIOUS PORTIONS ...

    SBIR Phase II 1987 Department of Health and Human Services
  9. ELCA ASSAY OF CLINICALLY IMPORTANT CLOTTING FACTORS

    SBC: Elcatech, Inc.            Topic: N/A

    A NEW TECHNIQUE HAS BEEN DEVELOPED TO ASSAY CLOTTING FACTORS: SOLID-PHASE FIBRINOGEN AND LABELLED FIBRINOGEN TOGETHER ARE USED AS A SUBSTRATE TO DETECT THROMBIN GENERA- TED FROM THE CLOTTING CASCADE. WHEN THROMBIN CLEAVES BOTH FORMS OF FIBRINOGEN TO FIBRIN, THE LABELLED FIBRIN IN SOLU- TION ASSOCIATES WITH THE SOLID PHASE. THIS TECHNIQUE, WHICHHAS BEEN NAMED "ENZYME-LINKED COAGULATION ASSAY" OR EL ...

    SBIR Phase II 1987 Department of Health and Human Services
  10. R & D OF AN IMPROVED LITHIUM ELECTRODE FOR HIGH-ENERGY BATTERIES

    SBC: Electrochimica Corp.            Topic: N/A

    HIGH-ENERGY RECHARGEABLE LITHIUM BATTERIES WOULD BE OF GREATIMPORTANCE FOR THE ENTIRE FIELD OF HEART PUMP DEVELOPMENT. FUTURE PROGRESS IN THIS AREA IS SHOWN TO DEPEND ON SUCCESS- FUL DEVELOPMENT OF A LITHIUM ELECTRODE (ANODE) WITH DESIRABLE RECHARGEABILITY CHARACTERISTICS. THE BASIC CRITERIA FOR RECHARGEABILITY OF LITHIUM ANODES ARE DISCUSSEDAS WELL AS THE ELECTROCRYSTALLIZATION PROCESS OF WHISKER ...

    SBIR Phase II 1987 Department of Health and Human Services

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