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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. STIMULUS PAIRS IN 3D AUDITORY BRAINSTEM RESPONSE

    SBC: ABRATECH CORPORATION            Topic: N/A

    THE GOAL OF THIS RESEARCH IS TO DETERMINE THE FEASIBILITY OF COMBINING THREE-CHANNEL RECORDING OF THE AUDITORY BRAINSTEM RESPONSE (ABR) WITH A STIMULUS-PAIRS TECHNIQUE SO AS TO MEASURE THE DECREMENT IN RESPONSE THAT OCCURS IN THE RELATIVE REFRACTORY PERIOD (RRP). THIS METHOD WILL PERMIT DETECTION OF ANY ABNORMALITIES THAT AFFECT THE RRP, AS THE PARAMETERS CAN BE ADJUSTED SO THAT THERE IS DECREMENT ...

    SBIR Phase I 1987 Department of Health and Human Services
  2. MEASUREMENT OF INTERLEUKIN-2 AND INTERLEUKIN-2 RECEPTOR BY ELISA

    SBC: Advanced Allergy Res Ctrs Inc            Topic: N/A

    DURING THE PAST 20 YEARS, DIFFERENT BIOLOGICAL ACTIVITIES HAVE BEEN DESCRIBED FOR LYMPHOKINES PRODUCED BY ACTIVATED LEUKOCYTES. INTERLEUKIN-1 (IL-1) IS A FACTOR PRODUCED BY ACTIVATED MONONUCLEAR PHAGOCYTES AND IS ESSENTIAL FOR SUPPORTING BOTH T-CELL AND B-CELL RESPONSES. ACTIVATED T CELLS PRODUCE INTERLEUKIN-2 (IL-2), A FACTOR NECESSARY FOR T-CELL PROLIFERATION. THIS SOLUBLE FACTOR EXERTS ITS BIOL ...

    SBIR Phase I 1987 Department of Health and Human Services
  3. ASSAY FOR PREDICTING METHOTREXATE SENSITIVITY IN HUMAN BREAST CANCER

    SBC: Aeron Biotechnology, Inc.            Topic: N/A

    THE LONG-RANGE GOAL OF THIS PROPOSAL IS TO DEVELOP AN IN VITRO TEST TO IMPROVE SELECTION OF THERAPIES FOR INDIVD- UAL BREAST CANCER PATIENTS BY PREDICTING RESPONSE TO METHO- TREXATE. EXISTING ASSAYS FOR BREAST CANCER CELLS CANNOT DE-TERMINE METHOTREXATE SENSITIVITY BECAUSE OF REQUIREMENTS FORFOR FEEDER LAYERS AND MEDIUM COMPONENTS THAT CAN RESCUE SEN-SITIVE CELLS. THIS PROPOSA WILL,THEREFORE, EVAL ...

    SBIR Phase II 1987 Department of Health and Human Services
  4. CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR ELECTRODES

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  5. AN IMAGE PREPARATION AND PRESENTATION SYSTEM FOR PSYCHOBIOLOGY

    SBC: American Innovision, Inc.            Topic: N/A

    NEWLY AVAILABLE TECHNOLOGY MAKES IT POSSIBLE TO CONSTRUCT VIDEO-BASED DEVICES FOR PREPARING AND PRESENTING VIDEO IMAGES THAT INCORPORATE FUNCTIONS OF MANY DIFFERENT TYPES OFIMAGE PRESENTATION SYSTEMS CURRENTLY IN USE IN LEARNING, BEHAVIOR, AND VISION RESEARCH. THE IMAGE EDITOR WOULD INCLUDE THE CAPACITY TO TAKE SELECTED PORTIONS OF VIDEO IMAGES AND REARRANGE THEM AS DESIRED TO CREATE A STIMULUS IM ...

    SBIR Phase II 1987 Department of Health and Human Services
  6. FALL-EVENT RECORDING SYSTEM

    SBC: ANCO ENGINEERS, INC.            Topic: N/A

    TO FURTHER BIOMEDICAL AND CLINICAL RESEARCH INTO THE AGING PROCESS, A VIDEO-RECORDING SYSTEM PERMITTING THE GENERATION OF A VIDEO DATA LIBRARY OF FALL EVENTS IS NEEDED. THIS PROPOSAL DELINEATES THE FUNCTIONAL REQUIREMENTS OF A VIDEO-RECORDING SYSTEM THAT WOULD AUTOMATICALLY RECORD FALL EVENTS. ITS UNIQUE FEATURES WILL INCLUDE THE ABILITY TO RECORD THE ENTIRE EVENT, INCLUDING THE CIRCUMSTANCES AND ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. QUANTIFICATION OF BASOPHIL-HISTAMINE RELEASE BY EIA

    SBC: Analatom Incorporated            Topic: N/A

    HISTAMINE IS AN IMPORTANT BIOCHEMICAL MEDIATOR THAT CAUSES ALLERGIC SYMPTOMS. IGE MOLECULES HAVE A HIGH AFFINITY FOR RECEPTORS ON BASOPHILS. THE PRESENCE OF SPECIFIC ALLERGENS WILL BRIDGE IGE BOUND ON BASOPHIL AND INITIATE A CHAIN OF EVENTS LEADING TO HISTAMINE RELEASE. QUANTIFYING BASOPHIL-HISTAMINE RELEASE ESSENTIALLY MEASURES THE CELL-BOUND, ALLERGEN-SPECIFIC IGE AND WILL ALLOW EVALUATION OF A ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. A METHIONINASE FOR METHIONINE-DEPENDENT CHEMOTHERAPY

    SBC: ANTICANCER, INC.            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  9. COMPUTER FOLDING OF RNA MOLECULES USING MONTE CARLO METHODS

    SBC: Applied Sciences Consultants,            Topic: N/A

    N/A

    SBIR Phase I 1987 Department of Health and Human Services
  10. CHRONIC DATA ACQUISITION SYSTEM AND PLAYBACK TO COMPUTER

    SBC: August Design, Inc.            Topic: N/A

    CONSIDERABLE EVIDENCE EXISTS THAT ANALYSIS OF THE ELECTRO- CARDIOGRAM OVER EXTENDED PERIODS OF TIME PROVIDES CLINICALLYSIGNIFICANT INFORMATION IMPORTANT IN THE DIAGNOSIS AND TREATMENT OF CARDIAN DISEASE. AVAILABLE AMBULATORY MONITOR-ING DEVICES ARE ADEQUATE FOR 24-HOUR PERIODS; LIMITATIONS ARE EVIDENT WHEN LONGER PERIODS ARE REQUIRED. THE PROJECT WILL ESTABLISH THE FEASIBILITY OF BIOLOGICAL DATA A ...

    SBIR Phase II 1987 Department of Health and Human Services

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