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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A METAL-OXIDE CHARACTERISTIC-LINE X-RAY IMAGING SOURCE

    SBC: Adelphi Technology, Inc.            Topic: N/A

    THERE IS A NEED FOR A CORONARY-ARTERY DISEASE SCREENING METHOD NOT REQUIRING THE RISK OF AN ARTERIAL CATHETER. DIGITAL-SUBTRACTION RADIOGRAPHS USING IODINE-K-EDGE SUBTRACTION SUFFER FROM LOW X-RAY INTENSITIES AND REQUIRE LARGE IODINE CONCENTRATIONS PRECLUDING NON-INVASIVE TECHNIQUES. BRIGHTER X-RAY SOURCES ARE NEEDED. WE PROPOSE TO CONDUCT AN EVALUATION OF METAL OXIDES AS CHARACTERISTIC-LINE X-RAY ...

    SBIR Phase I 1988 Department of Health and Human Services
  2. HHANES SELECTABLE CANCER DATA BASE SYSTEM

    SBC: 3s Navigation (dba For            Topic: N/A

    THE HISPANIC HEALTH AND NUTRITION EXAMINATION SURVEY (HHANES) CONTAINS A WEALTH OF INFORMATION FOR THE CANCER RESEARCH PROFESSIONAL. THE UTILITY OF THIS DATA BASE CAN BE SIGNIFICANTLY IMPROVED BY PROVIDING A SIMPLE USER INTERFACE SOFTWARE PACKAGE THAT CONVERTS THE DATA INTO USABLE INPUT FOR A COMMERCIAL RELATIONAL DATA BASE MANAGEMENT SYSTEM (RDBMS). ONCE THE HHANES DATA HAS BEEN CONVERTED INTO TH ...

    SBIR Phase I 1988 Department of Health and Human Services
  3. DEVELOPMENT OF DIAGNOSTIC PROBES FOR AUTOIMMUNE DISEASE

    SBC: Agouron Pharmaceuticals Inc.            Topic: N/A

    A CHARACTERISTIC FEATURE OF MANY RHEUMATIC DISEASES IS THE PRESENCE OF CIRCULATING ANTINUCLEAR ANTIBODIES. ASSAYS BASED ON THE MEASUREMENT OF THESE ANTIBODIES ARE ESTABLISHED IN THE CLINICAL LABORATORY FOR THE DIAGNOSIS OF THESE DISEASES, BUT OFTEN WITHOUT THE BENEFIT OF HAVING WELL-CHARACTERIZED OR ISOLATED TARGET ANTIGENS. ONE SUCH AUTOIMMUNE DISEASE IS SCLERODERMA OR PROGRESSIVE SYSTEMIC SCLERO ...

    SBIR Phase II 1988 Department of Health and Human Services
  4. SITE-DIRECTED DRUG DESIGN AGAINST PLASMODIUM FALCIPARUM.

    SBC: Agouron Pharmaceuticals Inc.            Topic: N/A

    N/A

    SBIR Phase I 1988 Department of Health and Human Services
  5. APPLICATION OF EVIDENTIAL REASONING IN MEDICAL DIAGNOSIS

    SBC: Akm Associates, Inc.            Topic: N/A

    A PROPOSAL FOR DEVELOPING A MEDICAL EXPERT SYSTEM SHELL FOR APPLICATION IN VARIOUS AREAS OF MEDICINE (INTERNAL MEDICINE,LABORATORY MEDICINE, PSYCHOLOGY, ETC.) THAT IS BASED ON A NEW METHOD FOR EVIDENTIAL REASONING IS ADVANCED. THIS SYSTEM CAN BE APPLIED AS: (1) A SCREENING SYSTEM FOR DETECTING RISK PATIENTS IN THE HOSPITAL, THE OUT-PATIENT DEPARTMENT, AND THE PRACTITIONER'S OFFICE (2) A LABORATORY ...

    SBIR Phase I 1988 Department of Health and Human Services
  6. VIDEOTAPE FEEDBACK IN DRUG TREATMENT: A TRAINING PROGRAM

    SBC: Allen/loeb Assoc            Topic: N/A

    VIDEOTAPE FEEDBACK HAS BEEN USED AS AN EFFECTIVE TECHNIQUE IN DRUG THERAPY FOR OVER 25 YEARS. IT IS AN IMPORTANT COMPONENT OF THE JOB SEEKERS' WORKSHOP(JSW), AN APPROACH TO HELPING DRUG TREATMENT CLIENTS BECOME EMPLOYED THAT HAS BEENSHOWN TO BE EFFECTIVE IN THREE CONTROLLED STUDIES. THE JSW DISSEMINATION PROJECT HAS SUCCESSFULLY EMPLOYED VIDEO FEEDBACK AS A TOOL FOR TRAINING JSW GROUP LEADERS IN D ...

    SBIR Phase I 1988 Department of Health and Human Services
  7. ELISAS FOR ISLET CELL AUTOIMMUNITY AND PREDIABETES

    SBC: Allergy Immuno Technologies            Topic: N/A

    STRONG EVIDENCE HAS ACCUMULATED TO SUGGEST THAT INSULIN-DEPENDENT DIABETES IS THE RESULT OF AUTOANTIBODIES AGAINST INSULIN AND/OR SUBCELLULAR COMPONENTS OF THE CELLS OF THE ISLET OF LANGERHANS. DETECTION OF THESE AUTOANTIBODIES WILL GIVE PRIOR KNOWLEDGE OF THE DISEASE IN ORDER THAT PREVENTIVE MEASURES CAN BE TAKEN TO AVERT OR DELAY THE DISEASE. IN PHASE FRACTIONS FROM PURCHASED SEMI-SYNTHETIC HUMA ...

    SBIR Phase I 1988 Department of Health and Human Services
  8. SERODIAGNOSIS OF ULCER

    SBC: Allergy Immuno Technologies            Topic: N/A

    SEVERAL SPECIES OF CAMPYLOBACTER ARE KNOWN TO BE ASSOCIATED WITH WIDE RANGE OF HUMAN AND ANIMAL ILLNESSES, MAINLY GASTROENTERITIS, COLITIS, SEPSIS AND URINARY TRACT INFECTIONS. RECENTLY MANY STUDIES CONFIRMED THE CORRELATIONBETWEEN THE PRESENCE OF C. PYLORIDIS (C. PYLORI) ON THE GASTRIC MUCOSA AND DUODENAL ULCERATION. THE MECHANISM BY WHICH THIS ORGANISM INDUCES ULCER IS NOT CLEAR YET BUT IT IS KN ...

    SBIR Phase I 1988 Department of Health and Human Services
  9. CELLULAR PARAMETERS OF DRUG SENSITIVITY IN HUMAN TUMORS IN VITRO

    SBC: ANTICANCER, INC.            Topic: N/A

    AN IMPORTANT NEED IN CANCER CHEMOTHERAPY IS A HIGHLY PREDICTIVE IN VITRO CHEMOSENSITIVITY ASSAY. A MAJOR IMPEDIMENT TO THE DEVELOPMENT OF SUCH A TEST HAS BEEN THE LACK OF A SUITABLE SYSTEM FOR CULTURING HUMAN TUMORS IN VITRO SO THAT THEY REPRESENT TUMORS IN THE IN VIVO STATE. TO OVERCOME THIS PROBLEM, ANTICANCER, INC. HAS RECENTLY DEVELOPED A TUMOR CULTURE SYSTEM FOR THE IN VITRO GROWTH OF DIVERSE ...

    SBIR Phase II 1988 Department of Health and Human Services
  10. COLON-CANCER-SPECIFIC GENES AS PROBES

    SBC: ANTICANCER, INC.            Topic: N/A

    DUE TO AN INCOMPLETE UNDERSTANDING OF THE DISEASE, THE PROGNOSIS OF COLON CANCER, A HIGH-INCIDENCE CANCER IN WESTERN COUNTRIES, HAS NOT IMPROVED SIGNIFICANTLY. MOST OF THE STUDIES IN THE MOLECULAR BIOLOGY OF COLON CANCER HAVE FOCUSED ON THE STUDY OF A LIMITED SET OF APPROXIMATELY 25-40GENES, TERMED ONCOGENES, THAT CAN ONLY BE DETECTED IF THEY HAVE A COUNTERPART IN RETROVIRUSES, OR IF THEY CAN ONCO ...

    SBIR Phase I 1988 Department of Health and Human Services

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