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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. AUDITORY BRAINSTEM RESPONSE AT HIGH STIMULUS RATES

    SBC: ABRATECH CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 1989 Department of Health and Human Services
  2. THE APPLICATION OF CHANNELING RADIATION TO NONINVASIVE ANGIOGRAPHY

    SBC: Adelphi Technology, Inc.            Topic: N/A

    THE PURPOSE OF THIS WORK IS TO CONDUCT AN EVALUATION OF CHANNELING RADIATION FOR THE NONINVASIVE ASSESSMENT OF CORONARY ARTERY DISEASE IN HUMANS. THE HIGH BRIGHTNESS, LASER-LIKE COLLIMATION, LINEAR POLARIZATION, AND QUASIMONO- CHROMATICITY OF CHANNELING RADIATION MAKE IT AN IDEAL SOURCEOF X-RAYS FOR MEDICAL APPLICATIONS. RECENT EXPERIMENTS USING SYNCHROTRON EMISSION AS A SOURCE OF X-RAYS, COUPLED ...

    SBIR Phase II 1989 Department of Health and Human Services
  3. SITE-DIRECTED DRUG DESIGN AGAINST PLASMODIUM FALCIPARUM.

    SBC: Agouron Pharmaceuticals Inc.            Topic: N/A

    THE ULTIMATE OBJECTIVE OF THIS PROJECT IS TO UTILIZE THE INFORMATION AVAILABLE IN THE THREE-DIMENSIONAL CRYSTAL STRUCTURE OF AN ENZYME IN THE RATIONAL DESIGN OF DRUGS WHICHWILL BE EFFECTIVE AGAINST PLASMODIUM FALCIPARUM. THE SPECIFIC ENZYME TARGET IS THE BIFUNCTIONAL DIHYDROFOLATE REDUCTASE-THYMIDYLATE SYNTHASE (DHFR-TS) OF P. FALCIPARUM. THE ACHIEVEMENT OF THIS GOAL WILL INVOLVE A CONCERTED EFFOR ...

    SBIR Phase II 1989 Department of Health and Human Services
  4. CARRAGEENAN-STABILIZED COLLOIDAL GOLD BIOSENSOR ELECTRODES

    SBC: ALDERON BIOSCIENCES, INC.            Topic: N/A

    A GROWING NEED EXISTS FOR NEW AND IMPROVED SECOND-GENERATIONELECTROCHEMICAL BIOSENSORS CAPABLE OF RELIABLY DETECTING, MONITORING, AND ANALYZING A VARIETY OF CHEMICAL AND BIOLOGICAL COMPOUNDS IN THE ENVIRONMENT, IN PROCESS STREAMS,AND IN BODY FLUIDS. SUCH SENSORS WOULD FIND EXTENSIVE APPLICATIONS IN THE PREVENTION, DIAGNOSIS, AND TREATMENT OF MANY DISEASES; HOWEVER, IN THE UNITED STATES, ELECTROCHE ...

    SBIR Phase II 1989 Department of Health and Human Services
  5. ADVANCES IN SMOKING CESSATION

    SBC: Allen/loeb Assoc            Topic: N/A

    SIGNIFICANT ADVANCES IN TREATMENT METHODS TO HELP PEOPLE STOP SMOKING HAVE BEEN MADE THROUGH RESEARCH IN THE PAST DECADE, YET MANY OF THESE ADVANCES ARE NOT BEING USED IN THE FIELD. THERE IS NO HANDS-ON PROGRAM FOCUSED ON DISSEMINATING NEW TREATMENT METHODS TO INSTITUTIONS AND INDIVIDUALS WHO CONDUCT SMOKING CESSATION PROGRAMS. A TRAINING PROGRAM FOR CESSATION GROUP LEADERS WILL BE DEVELOPED AND T ...

    SBIR Phase I 1989 Department of Health and Human Services
  6. MOLECULAR DISPLAY

    SBC: Allotech Inc            Topic: N/A

    ALLOTECH, INC., WILL DEMONSTRATE A CATHODE RAY TUBE (CRT) DISPLAY THAT PRESENTS THE THREE-DIMENSIONAL CONFIGURATIONS OF COMPLEX STRUCTURES OF BIOMEDICAL INTEREST. THIS PROJECT WILL LIMIT ITS SCOPE TO STICK FIGURES OF MOLECULES. THE DISPLAY TECHNOLOGY PRODUCES THE VISUAL PERCEPTION OF STRUCTURE AND OF SPACE WITHOUT THE USE OF SPECIAL GLASSES OR OTHER OPTICS, USING A CONVENTIONAL CRT. THIS WILL BE A ...

    SBIR Phase I 1989 Department of Health and Human Services
  7. PROSTHETIC CONTACT PRESSURE INSTRUMENTATION

    SBC: ANCO ENGINEERS, INC.            Topic: N/A

    CURRENTLY, PROSTHETIC FITTING IS VERY SUBJECTIVE. LITTLE EXISTS IN THE WAY OF TRANSDUCERS TO AID THE PROSTHETIST. THIS PROJECT WILL DEVELOP A TRANSDUCER, MADE OF A THIN PIEZOELECTRIC FILM, THAT COULD MEASURE LOADS AT THE STUMP/PROSTHETIC INTERFACE. THIS FILM HAS THE PROPERTIES OF FLEXIBILITY, DYNAMIC RANGE, AND SMALL SIZE TO MEET THE REQUIREMENTS OF THESE MEASUREMENTS. THE USE OF THIS TRANSDUCER W ...

    SBIR Phase I 1989 Department of Health and Human Services
  8. SIGLE-USE, NON-REVERSIBLE SYRINGE

    SBC: ANCO ENGINEERS, INC.            Topic: N/A

    IT IS WELL ESTABLISHED THAT THE SHARING OF SYRINGES BETWEEN INFECTED AND NONINFECTED I.V. DRUG USERS HAS BEEN A MAJOR CAUSE IN THE SPREAD OF AIDS. THE DEVELOPMENT OF A SINGLE-USE MECHANISM THAT COULD BE INCORPORATED INTO ALL DISPOSABLE SYRINGES WOULD PREVENT THEM FROM BEING SALVAGED AFTER LEGITIMATE USE AND REUSED BY I.V. DRUG USERS, THEREBY MITIGATING OR ELIMINATING THE SPREAD OF THE EPIDEMIC BY ...

    SBIR Phase I 1989 Department of Health and Human Services
  9. IDENTIFICATION OF ALZHEIMER'S-SPECIFIC TAU ALTERATIONS

    SBC: Athena Neurosciences Inc.            Topic: N/A

    ALZHEIMER'S DISEASE (AD) IS A DEVASTATING ILLNESS CURRENTLY AFFECTING OVER 2.5 MILLION PEOPLE IN THE UNITED STATES, WITHFINANCIAL COSTS FOR DIAGNOSIS AND LONG-TERM CARE EXCEEDING $50 BILLION ANNUALLY. THE ETIOLOGY OF AD IS UNKNOWN, BUT ITS TWO BIOCHEMICAL HALLMARKS ARE THE PRESENCE OF EXTRACELLULAR PLAQUE AND INTRACELLULAR NEUROFIBRILLARY TANGLES (NFT) IN THE BRAINS OF AFFECTED INDIVIDUALS. THE GR ...

    SBIR Phase I 1989 Department of Health and Human Services
  10. IDENTIFICATION OF ALZHEIMER-SPECIFIC ANTIGENS IN CSF

    SBC: Athena Neurosciences Inc.            Topic: N/A

    THE OBJECTIVE OF THIS RESEARCH IS TO DEFINE ANTIGENS IN THE CEREBROSPINAL FLUID (CSF) THAT ARE SPECIFIC TO ALZHEIMER'S DISEASE. ULTIMATELY, THE POTENTIAL RESULTS OF THIS EFFORT MAY BE THE DEVELOPMENT OF A CSF-BASED DIAGNOSTIC IMMUNOASSAYFOR USE BOTH AS A DIAGNOSTIC MARKER AND AS A USEFUL ADJUNCT TO MONITOR EVENTUAL THERAPY. THE METHODOLOGY TO IDENTIFY THE DIAGNOSTIC MARKERS INVOLVES THE SCREENING ...

    SBIR Phase I 1989 Department of Health and Human Services

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