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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. ATTENTION IN EVOKED RESPONSES AT HIGH-REPETITION RATES

    SBC: ABRATECH CORPORATION            Topic: N/A

    N/A

    SBIR Phase I 2002 Department of Health and Human Services
  2. ATTENTION IN EVOKED RESPONSES AT HIGH-REPETITION RATES

    SBC: ABRATECH CORPORATION            Topic: N/A

    N/A

    SBIR Phase II 2002 Department of Health and Human Services
  3. MULTIWELL COLORIMETRIC ASSAY FOR DNA REPAIR PROTEIN.

    SBC: ACTIVE MOTIF, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): DNA damages are key events during carcinogenesis. Deficiencies in repairing damaged DNA represent a poor prognosis during tumorigenesis and/or cancer treatment. Besides monitoring DNA damage formation, it would be helpful to monitor DNA repair protein activity. We propose to develop a new technology that allows for high-throughput and fast analysis of the most ...

    SBIR Phase I 2002 Department of Health and Human Services
  4. FLUOROGENIC IMAGING MOLECULES FOR PROTEASE/KINASE ASSAYS

    SBC: ACTIVE MOTIF, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of this proposal is to develop a series of fluorogenic imaging molecules, which can be easily delivered into viable cells and monitor cellular functions. The FIMs are composed of a peptide backbone containing a target site for a kinase or a protease. Some designs borrow from the molecular beacon approach and carry flurophore/quencher moieties, while oth ...

    SBIR Phase I 2002 Department of Health and Human Services
  5. NOVEL SP1 & ER DNA-BINDING ASSAY FOR CANCER PROGNOSIS

    SBC: ACTIVE MOTIF, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal focuses on the development of multi-well ELISA-like assays to quantify DNA binding activity of two breast cancer prognosis markers, Sp1 and ER, with much more sensitivity and high throughput than standard DNA gel shift techniques. Such an approach has already been successfully applied to monitoring transcription factor activation by Active Motif ...

    SBIR Phase I 2002 Department of Health and Human Services
  6. BETA-SECRETASE ASSAYS TO DISCOVER DRUGS FOR ALZHEIMER'S

    SBC: ACTIVESITE BIOTECH            Topic: N/A

    Alzheimer's disease (AD) is a debilitating mental disorder that results in a progressive loss of cognitive functions. However, there is no effective treatment for this disease. The neurotoxin AB peptide plays a central role in AD, involving increased production and accumulation of AB in brain amyloid plaques. Proteolytic processing of the amyloid precursor protein (APP) is required to generate AB, ...

    SBIR Phase I 2002 Department of Health and Human Services
  7. BETA-SECRETASE ASSAYS TO DISCOVER DRUGS FOR ALZHEIMER'S

    SBC: ACTIVESITE BIOTECH            Topic: N/A

    Alzheimer's disease (AD) is a debilitating mental disorder that results in a progressive loss of cognitive functions. However, there is no effective treatment for this disease. The neurotoxin AB peptide plays a central role in AD, involving increased production and accumulation of AB in brain amyloid plaques. Proteolytic processing of the amyloid precursor protein (APP) is required to generate AB, ...

    SBIR Phase II 2002 Department of Health and Human Services
  8. ACTIVITY-BASED PROTEOMICS FOR TOXICOLOGICAL ANALYSIS

    SBC: ACTIVX BIOSCIENCES            Topic: N/A

    DESCRIPTION (provided by applicant): Chemical probes will be developed to profile toxicities resulting from drug interactions. We have developed fluorescent probes that exclusively identify active members of the serine hydrolase super-family of enzymes. Using our technique, we can elucidate activity profiles of diseases, and broadly investigate interactions between the proteome and potential thera ...

    SBIR Phase I 2002 Department of Health and Human Services
  9. QUASI-MONOCHROMATIC X-RAY SOURCE FOR MAMMOGRAPHY

    SBC: Adelphi Technology, Inc.            Topic: N/A

    Description (provided by applicant): The objective of the proposed research is to construct a prototype narrow-bandwidth x-ray source for mammography using a thin, efficient hybrid radiator driven by a relativistic electron beam of moderate energy and current. The high x-ray yield (photons/electron) of the source permits the use of modest electron-beam currents, preventing thermal damage to the ra ...

    SBIR Phase I 2002 Department of Health and Human Services
  10. QUASI-MONOCHROMATIC X-RAY SOURCE FOR MAMMOGRAPHY

    SBC: Adelphi Technology, Inc.            Topic: N/A

    Description (provided by applicant): The objective of the proposed research is to construct a prototype narrow-bandwidth x-ray source for mammography using a thin, efficient hybrid radiator driven by a relativistic electron beam of moderate energy and current. The high x-ray yield (photons/electron) of the source permits the use of modest electron-beam currents, preventing thermal damage to the ra ...

    SBIR Phase II 2002 Department of Health and Human Services

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