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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Error Reduction in Dipole-Source Localization Models

    SBC: ABRATECH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): We are developing means to reduce errors in Dipole Source Localization (DSL). DSL is commonly used to analyze brain waves for clinical and research purposes. It is known from our work and the work of others that the models used to compute the DSL are not perfect, but it is not known how much the imperfect models affect the solutions obtained. Based upon our ...

    SBIR Phase II 2005 Department of Health and Human Services
  2. Healthy Dining Finder Restaurant Logo and Website Program

    SBC: ACCENTS ON HEALTH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-term goal of Healthy Dining Finder is to help reduce the prevalence of risk factors related to obesity and nutrition-related diseases by increasing the availability of, and information about, healthier meals at restaurants nationwide. With the cooperation of the National Restaurant Association, Accents On Health, Inc. (dba Healthy Dining) will approac ...

    SBIR Phase II 2005 Department of Health and Human Services
  3. High throughput assay for small G protein activation

    SBC: ACTIVE MOTIF, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The small GTP binding protein superfamily (consisting of small, monomeric GTP hydrolyzing proteins or GTPases) regulates diverse cellular processes including gene expression, cellular proliferation, cytoskeletal reorganization, vesicle trafficking, and nucleocytoplasmic transport. Activated point mutants of Ras GTPases have been found in over 30% of all human ...

    SBIR Phase I 2005 Department of Health and Human Services
  4. Drug discovery of anti-ADDL therapeutics for Alzheimer's

    SBC: Acumen Pharmaceuticals, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): Recent evidence suggests that the primary cause of Alzheimer's disease is the progressive accumulation of neurotpxic oligomeric assemblies of the Abeta 1-42 protein. These neurotoxic oligomeric species are known as ADDLs (Ab-derived diffusible ligands). In Tg2576 AD mice, a transgenic Alzheimer's disease animal model, memory performance declines as ADDL levels ...

    SBIR Phase I 2005 Department of Health and Human Services
  5. Biomarker for Alzheimer's Related Cognitive Deficits

    SBC: Acumen Pharmaceuticals, Inc            Topic: N/A

    DESCRIPTION (provided by applicant): The molecular and cellular details underlying Alzheimer's disease (AD) are being defined at an accelerating pace, leading to new therapeutic discovery efforts that target reduction of A-beta or ADDLs (A-beta-derived diffusible ligands), the neurotoxic oligomeric assemblies of A-beta 1-42. Elevated ADDL levels correlate with synaptic dysfunction, and the appear ...

    SBIR Phase I 2005 Department of Health and Human Services
  6. Medicare Information Resource Center (MIReC)

    SBC: Acumen, LLC            Topic: N/A

    The purpose of the project is to facilitate the acquisition and linking of data from the Centers for Medicare and Medicare Services (CMS) to participants of surveys and registries sponsored by NIA and relate federal agencies, and to promote the use of these data for research and public policy. The intent is to create an infrastructure that will reduce the expense and time required to obtain, creat ...

    SBIR Phase I 2005 Department of Health and Human Services
  7. High-resolution tomography for small animal imaging

    SBC: Adelphi Technology, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): The goal of this proposal is to develop a nanometer-scale resolution computerized tomographic imaging system for small animal and molecular imaging. This will be achieved by developing a specialized x-ray source designed to work with x-ray compound refractive lenses. The source will provide intense, spatially uniform x-ray output over a large area with proper a ...

    SBIR Phase I 2005 Department of Health and Human Services
  8. Neutron Microscope for In-Vivo Imaging

    SBC: Adelphi Technology, Inc.            Topic: N/A

    The objective of the proposed research is to design an inexpensive, compact neutron microscope capable of imaging biological material that can meet specific medical research and clinical needs. One particular clinical application for the thermal or cold neutron microscope that we will address in the proposed program is to provide a new imaging modality in boron neutron capture therapy (BNCT) for t ...

    SBIR Phase I 2005 Department of Health and Human Services
  9. Dark-Field Hard-X-ray Microscope

    SBC: Adelphi Technology, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase 1 project will develop a hard-x-ray microscope capable of producing dark-field images for the detection of colloidal gold particles. Gold colloidal particles are used as labels in the study of antigens and cell and protein structure. In prior research, Adelphi Technology Inc. has developed compound refractive lenses ...

    SBIR Phase I 2005 Department of Health and Human Services
  10. Sleep Apnea Identification & Treatment in Dentistry

    SBC: ADVANCED BRAIN MONITORING, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Obstructive Sleep Apnea (OSA) is the most common disorder observed in the practice of sleep medicine and is responsible for more mortality and morbidity than any other sleep disorder. OSA causes daytime drowsiness and cognitive impairment, and has been associated with hypertension and increased risk of cardiovascular disease, diabetes and stroke. Untreated OSA ...

    SBIR Phase I 2005 Department of Health and Human Services

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