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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. IMPROVED HYPOGLYCEMIA RESCUE DEVICE

    SBC: XERIS PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this program is to develop of a clinical prototype, semi-solid drug formulation and auto-injector pen that deliver microliter volumes of a glucagon dose without reconstitution for hypoglycemic emergencies. To assess the feasibility of this objective, it is necessary to first demonstrate that glucagon can be formulated into an ultra- concentrate ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. Brain-activity during sedation predicting post-sedation explicit-memory

    SBC: ABRATECH CORPORATION            Topic: N/A

    DESCRIPTION (provided by applicant): This project will study electrical brain-activity measures that may be able to indicate whether or not long-term memory is occurring, under light sedation. The goal is to develop a brain-monitor to be used in the operating room to ascertain if a patient's level of anesthesia has become too light, such that the patient can experience pain, and understand what is ...

    SBIR Phase I 2009 Department of Health and Human Services
  3. Identification of Anti-HIV Lead Compounds Targeting Rev

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a significant need for novel HIV therapies given the emergence of viruses resistant to existing drug regimens. The Rev-RRE protein-RNA interaction in HIV plays an essential role in the transport of viral mRNA from the nucleus to the cytoplasm where it can be translated or packaged. In preliminary work, two distinct assays targeting the HIV Rev protein ...

    STTR Phase I 2009 Department of Health and Human Services
  4. Miniaturized DNA Sequencer for Identification of Microbial Pathogens

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Miniaturized DNA Sequencer for Identification of Microbial Pathogens Abstract. The goal of this project is develop a compact and inexpensive DNA sequencer based on the implementation of sequencing-by-synthesis chemistry on a droplet-based digital microfluidic cartridge. The proposed device would be capable of sequencing 10's to 100's of base pairs using an ine ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. Lab-on-a-chip for multiplexed newborn screening of lysosomal storage disorders

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Newborn screening is currently performed by collecting dried bloodspots from infants and then sending them to a lab for analysis. Lysosomal storage diseases alone number greater than 40 and there is an increasing necessity to screen for a number of disease conditions for which therapies are becoming available. Tandem mass spectrometry is an excellent multiplex ...

    SBIR Phase II 2009 Department of Health and Human Services
  6. Lab-on-a-chip for Neonatal Hyperbilirubinemia Screening

    SBC: ADVANCED LIQUID LOGIC            Topic: N/A

    DESCRIPTION (provided by applicant): Despite aggressive public health campaigning and strict guidelines for diagnosis and treatment, the estimated incidence of severe hyperbilirubinemia (defined as serum bilirubin levels greater than 99th percentile) is 1:70. Severe hyperbilirubinemia can cause a spectrum of neurologic dysfunction of which kernicterus is the most concerning. Kernicterus manifests ...

    SBIR Phase I 2009 Department of Health and Human Services
  7. Discovery of inhibitors of ALK for the treatment of cancer

    SBC: Zenobia Therapeutics, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Our aim is to discover novel safety assessment candidates (pre-clinical compounds) for the treatment of cancer by targeting the receptor tyrosine kinase (RTK), anaplastic lymphoma kinase (ALK). It is now proven that ALK has a widespread pathogenic involvement in cancer through the expression of either constitutively activated fusion proteins or activating mutat ...

    SBIR Phase I 2009 Department of Health and Human Services
  8. Selective Activation in Specific Neuronal Populations

    SBC: ADVANCED TARGETING SYSTEMS            Topic: N/A

    DESCRIPTION (provided by applicant): Selective Activation in Specific Neuronal Populations Summary: Molecules targeted towards cell surface markers have been used for years to identify specific cell types. It has been demonstrated over the course of the past decade that biologically-active molecules, when attached to these cell surface-binding molecules, can be delivered in a specific manner, util ...

    SBIR Phase I 2009 Department of Health and Human Services
  9. A Miniature Monitor for Time-Resolved Airborne Particle Chemistry

    SBC: Aerosol Dynamics Inc.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Our parent project aims to develop a small, lightweight, battery-powered collector suitable for time-resolved personal and micro-environmental monitoring of the chemical constituents of airborne particles. This revision submission aims to enhance that technology through the development of an air-to-air particle concentrator that is effective for ultrafine and n ...

    SBIR Phase II 2009 Department of Health and Human Services
  10. Retrograde Tracers with Suicide Enzyme?Prodrug to Study Specific Neural Circuits

    SBC: AFASCI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Tracing techniques have long been used to analyze specific neural pathways but do not reveal their function. Lesion techniques have also long been employed to analyze the function of neural pathways but are not very selective. Current lesion methods use excitotoxic, electrolytic or mechanical lesions, and transgenic expression of a toxic gene product. Here we p ...

    SBIR Phase I 2009 Department of Health and Human Services

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