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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Toward the Development of a Protein: Non-protein Macromolecular Adjuvants

    SBC: Hafion Inc.            Topic: NIAID

    An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tractOvercoming this problem will require the use of novel vaccine formulations andin particularthe use of novel immune enhancing agentsadjuvantsthat promote immune responses that are effective at mucosal sit ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Development of Enzyme Replacement Therapy for Complement C2-Deficiency

    SBC: NECTAGEN INC            Topic: NIAID

    The goal of this Phase I SBIR project is to develop a scalable method of Cpurification for use in Creplacement therapy based on a novel immunoaffinity chromatography resinDeficiency of complement CC Dis reported to be the most common hereditary defect among complement components with a prevalence ofPatients with homozygous complete deficiency suffer from recurring pyrogenic infections with encapsu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. 2nd-Generation Spinal Analgesic Resiniferatoxin

    SBC: INTERVENTIONAL ANALGESIX INC.            Topic: 101

    RTX is the most potent known agonist of the transient receptor potential cation channel subfamily V memberTRPVIt is a selective neurotoxin that can ablate TRPVbearing neural structuresmost importantlynociceptivepain sensingspinal nerve fibersand has been unequivocally demonstrated by several laboratories to induce long lasting analgesiachronic pain reliefWhy has RTX not be turned into a commercial ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Novel Communication Aid to Help Reduce Cognitive Load for Autistic Persons

    SBC: Koronis Biomedical Technologies Corp.            Topic: NIDCD

    Abstract In this Phase I SBIR projectKoronis Biomedical Technologies CorporationKBTproposes to develop a classroom communication aid for students with Autistic Spectrum DisorderASDChildren with ASD often have problems processing auditory information in conjunction with sensory hyper sensitivitynegative reactions to low level environmental stimuli generally considered to be innocuousThese disturban ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Vascular Deformation Mapping (VDM) for Automated, 3D Assessment of Thoracic Aortic Aneurysm

    SBC: Imbio, LLC            Topic: NHLBI

    PROJECT SUMMARY Thoracic aortic aneurysmTAAis a chronic condition that carries the risk of developing life threatening complications such as aortic dissectioni edelamination of the aortic walland rupturei etransmural tearingThe primary management objectives for TAA are to identify aortic dilation early and to surgically replace the aorta before it reaches a size that predicts future complicationsI ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Diagnostic Test for Detecting Recent Seizures in Epilepsy Patients

    SBC: Evogen, Inc.            Topic: 106

    Project SummaryAbstractEpilepsy affects approximatelyof the world populationtotaling andgtmillion patientsWhile anti epileptic drugAEDtreatment is successful in many patientsof patients continue to experience seizures causing physicians to adjust change medications or other treatment parametersCurrent diagnostic tools are incapable of differentiating between patients experiencing a recent seizure ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Commercialization of a CT-based Technique for BOS Assessment

    SBC: Imbio, LLC            Topic: NHLBI

    Patients who have undergone allogenic hematopoietic stem cell transplantation (allo-HSCT) or lungtransplantation often develop pulmonary complications. These transplant recipients often develop apotentially life threatening condition known as bronchiolitis obliterans syndrome (BOS), aconsequence of graft versus host disease (GVHD). Early diagnosis of BOS is vital for maintainingquality of life and ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Exo-Seq for the single molecule of DNA molecules

    SBC: Digital Nanogenetics LLC            Topic: 172

    ABSTRACT The long term goal of this project is the commercial development of a low cost Single Molecule SequencingSMStechnologycalled Exo Seqwhich employs a sequencing by subtraction strategy for high fidelity disassembly of low amounts of unamplified DNAsIn spite of the SMS approachExo Seq possesses superior single pass base call accuracyandgtusing a multiparameter identification strategy that ta ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Targeting bacteria, the innate response of the middle ear to infection, and host-pathogen interactions, using topical and transtympanic applications for the treatment of otitis media.

    SBC: EARNANO LLC            Topic: NICHD

    Otitis media is a world wide disease primarily affecting the pediatric population under the age ofyearsIt is the most common reason for pediatric care visits and antibiotic therapyOver prescription and poorcompliance have led to a reduced susceptibility of bacteria to antibiotics andconsequentiallyto recurrent and chronic ear diseasesClearlythere is a compelling need to investigate alternative the ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. BrainAware: Interactive digital psychoeducation for adolescents and young adults with substance use disorders

    SBC: ADVENTIUM ENTERPRISES, LLC            Topic: 500

    Treatment professionals struggle to get adolescents and young adults to engage and persist with treatment for substance abuse disorders. It is particularly difficult to maintain interest or enthusiasm with two core elements of evidence-based substance abuse treatment, psychoeducation and peer support. We propose to counter young peopleandapos;s resistance to treatment by creating an interactive ed ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
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