Award Data

An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tractOvercoming this problem will require the use of novel vaccine formulations andin particularthe use of novel immune enhancing agentsadjuvantsthat promote immune responses that are effective at mucosal sit ...

The goal of this Phase I SBIR project is to develop a scalable method of Cpurification for use in Creplacement therapy based on a novel immunoaffinity chromatography resinDeficiency of complement CC Dis reported to be the most common hereditary defect among complement components with a prevalence ofPatients with homozygous complete deficiency suffer from recurring pyrogenic infections with encapsu ...

Project Summary Age-related Macular Degeneration (AMD) is the leading cause of blindness in US. It affects over 25% of the people by the age 80. An estimated 25 million people are afflicted with AMD worldwide. Neovascular or “wet” AMD, which affects 10%–15% of AMD patients, is a rapid form of the disease and progresses to blindness if left untreated. Histopathologically, the disease involves ...

Project SummaryAbstractEpilepsy affects approximatelyof the world populationtotaling andgtmillion patientsWhile anti epileptic drugAEDtreatment is successful in many patientsof patients continue to experience seizures causing physicians to adjust change medications or other treatment parametersCurrent diagnostic tools are incapable of differentiating between patients experiencing a recent seizure ...

Glycosaminoglycans (GAGs) are polysaccharides composed of a repeated disaccharide subunit and known to be important for the maintenance of structure and mechanical properties of the extracellular matrix. More recently, changes in the content, size, and composition of GAGs have been found to play biological roles in disease processes as well. For example, chondroitin sulfate (CS) is the most abunda ...

Natural products or their derivatives have accounted for most of our current drugsdemonstrating their unique status asprivilegedmolecules that are well adapted for therapeutic useHowevernatural products have previously been unsuitable for modernhigh throughputHTdrug discovery screening approachesand as suchwere long ago abandoned in drug discovery programs of large pharmaThe substitute has been hi ...

ABSTRACT The long term goal of this project is the commercial development of a low cost Single Molecule SequencingSMStechnologycalled Exo Seqwhich employs a sequencing by subtraction strategy for high fidelity disassembly of low amounts of unamplified DNAsIn spite of the SMS approachExo Seq possesses superior single pass base call accuracyandgtusing a multiparameter identification strategy that ta ...

Project Summary/Abstract The ultimate goal of this phase II STTR proposal is to expand the capabilities of SABandapos;s diversitAb™ platform by continuing advanced development of Transchromosomic goats (TcGs). This will be accomplished by producing male and female goat endogenous immunoglobulin gene knockout cell lines that contain SAB Capraandapos;s human artificial chromosome (HAC) which encod ...

Abstract Radiologic imaging plays an important role in the care of patients with a variety of heart diseasesand the ways in which imaging are used for cardiac patients is rapidly evolvingIn the pasthigh end cardiac imaging has been dominated by rest stress procedures for evaluating myocardial perfusion in patients with known or suspected coronary artery diseaseIn the modern agehowevercardiac imagi ...

AbstractThrombosis affectstopatients in the United States annuallyand results in more thandeaths each yearRapid and complete removal of blood clots to re canalize blood vessels is criticalThe goal of this study is to develop a high efficient endovascular method to remove blood clots by combining laser and ultrasound techniquesCavitation is the main mechanism for both laser and ultrasound thromboly ...