Award Data

PROJECT SUMMARY Resective neurosurgery is essential for treating a range of neurologic conditions such as epilepsy and brain tumorsFor some patientswhose lesion is close to cortical language areaspostoperative expressive or receptive language deficit is a major and feared postoperative complicationMuch effort is devoted to identifying the cortical language regionsand relating such localization to ...

Major depressive disorder is a debilitating mood disorder that affects ~7% of US adults in their lifetime, costing the U.S. economy more than $200 billion a year. Drugs that increase monoaminergic signaling are the mainstay of depression therapy, but have a delayed onset of action and are only effective in about 50% of affected patients. Aberrant brain-derived neurotrophic factor (BDNF) signaling ...

Myasthenia gravis is a severe neuromuscular disease primarily caused by complement activating autoantibodies directed towards the skeletal muscle acetylcholine receptor. Present treatments are ineffectiveand uniformly have adverse effects, which negatively impact quality of life. Despite being a rare disease, myasthenia gravis is a costly one with a hospitalization expense of half a billion dollar ...

Project Summary In this Phase I SBIR projectImproving Mobile Access for Recruiting Study Volunteers from Underrepresented Populations for Alzheimerandapos s Disease Research and Other Studieswe will develop test and finalize a prototype mobile responsive website to enable broaderfasterand more cost efficient engagement of research study participants from underrepresented and minority populationsSp ...

PROJECT SUMMARY/ABSTRACT The postpartum period is a critical time, and more than half of all maternal deaths occur postpartum. Black women are 3-4 times more likely than white women to experience maternal mortality. In the US, 1 in 4 women do not have a timely postpartum visit, and adherence is even lower for women on Medicaid managed care plans. Our Parent Grant (R43MD014923) was funded to develo ...

The primary goal of this proposed research is to develop a rapid point-of-care test that assesses the risk of neonatal sepsis (NS) and/or necrotizing enterocolitis (NEC) in infants based on Inter-alpha inhibitor proteins (IAIP) levels in blood. The test is expected to be simple, user-friendly, portable and suitable for use in the NICU. NS and NEC are associated with high mortality and morbidity, i ...

Project SummaryNovel High Resolution Scintillation X ray Detectors for Digital Dentistry The transition from traditional film to digital X ray detectors has resulted in significant improvements across many areas for dental X ray imaging ranging from decreased wait timesimproved logistics and even lower radiation dose ratesOne significant drawback remains with digital X ray imaging howeverwhich is ...

Excessive alcohol use is the third-leading preventable cause of death in the U.S. with young adults ages 18-29 showing the highest rates of hazardous alcohol use. Community colleges serve over 12 million students, comprising 45% of all U.S. college students. Community college students (CCS) show rates of heavy alcohol use similar to students at traditional four-year residential (FYR) colleges, but ...

To address the need to mitigate cooperative and noncooperative in-band interference in airborne anti-submarine warfare (ASW) systems, ARiA will develop and demonstrate the feasibility of signal and information processing algorithms for mitigating various types of in-band interference. ARiA will develop and evaluate (1) model-based adaptive signal processing in space, time, and Doppler to mitigate ...

Within the increasingly contested undersea operational arena, the Navy needs a tactical and competitive advantage in undersea sensing and detection through improved situational awareness with respect to environmental parameters, such as sound speed profile (SSP) and bottom properties, that affect overall submarine sonar sensor performance. Current approaches for enhancing environmental situational ...