Award Data

Project Summary Opioids like morphine and hydrocodone are generally the most effective therapeutics for treatment of moderate to severe pain. However, their use is limited by serious side effects - tolerance, constipation, respiratory depression, physical dependence and high addictive potential. The frequency of clinical pain, coupled with a lack of alternative therapeutic options has led to a nat ...

This project addresses the need for increased opportunities for customized employment for individuals with cognitive disabilities by developing the Person-Centered Planning ToolKit. The Toolkit will enhance implementation of personcentered planning (PCP), often limited by lack of follow-through on action items and a lack of tools to match career preferences to specific customized employment opport ...

The goal of this NIH Phase I SBIR proposal is to develop and validate a new method to monitor the symptomatic toxicities and health related quality of life of cancer patients who are undergoing and have undergone radiation therapy during the course of their treatmentThe proposal is built around expertise in mobile application developmentVivonics Incand radiation oncologyDrTJ Fitzgerald of the Univ ...

The overall objective of this Fast Track SBIR contract project is to develop DigiBioMarCTMDigital BioMarkers for Clinical Impacta scalable and flexible cloud based platform to capture and analyze wearableimplantableor external device dataThis platform also provides an informatics tool for automated data aggregationintegrationand machine learning algorithmsIt is based on the scalable user centered ...

The goal of this SBIR is to provide proof of concept of Vetigenicscanine derived scFv phage display platform for rapidcost effective production of highly versatilecanine derived scFvsscFvs against CDCDand CTLAthree high valueimmunological molecules being targeted by antibody based strategies in human cancer immunotherapywill be isolatedSelected scFvs will be sequenced and binding affinities determ ...

Dopamine receptors are a family of G protein-coupled receptors (GPCRs), and can be further divided into D1-like (D1 and D5) and D2-like (D2, D3 and D4) subfamilies. In this proposal, we focus on D1 receptor, which is widely expressed in brain at high levels. Modulation of D1 activity is implicated in the treatment of many psychiatric and neurological disorders, such as schizophrenia, attention def ...

PROJECT SUMMARY GoDx, Inc. has been developing a prototype multiplexed paper strip device for the detection of the DNA and RNA of gastrointestinal pathogens at the point-of-need in andlt; 30 minutes with funding from the NCATS SBIR parent grant TR 001912. We have used the same platform technology we are developing in the parent grant to develop a rapid (andlt;30 minute), low-cost and instrument-fr ...

Today, urban underground spaces are shared by multiple utility companies for laying power lines, gas lines, water supply/sewage pipes, fiber-optic cables, etc. The recordings of such buried utilities are often erroneous, inadequate, or outdated (if they ever exist) due to insufficient surveying methodologies and as-built recording practices. Ability to accurately locate and provide awareness of bu ...

Pipeline operators employ cleaning tools for improving product throughput, inhibiting corrosion, and preparing their pipes for inline inspection. For many pipeline risk models, improving the scope and quality of input data is a long-term process. If the combined cost of pigging and inspecting was low and could be done simultaneously, pipeline operators would be encouraged to perform inspections mo ...

In the inspection and quality assurance framework, coercimetry refers to non-destructive testing of mechanical properties based on measurements of the magnetic characteristics of a metal. This technology relies on the continuous and noticeable (100-400%) increase in the magnitude of the coercivity, while the metal passes from as-delivered to its final state. As both magnetic and mechanical propert ...