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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. CNT-Vectored Delivery of mRNA for HIV-Vaccines

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Developing safe and effective preventives for HIV remains the hope for controlling the global AIDS epidemicRecentlymRNA vaccines have emerged as a promising alternative to conventional vaccine approaches because of their high potencycapacity for rapid developmentpotential for low cost manufactureTo datethere is no effective mRNA protective vaccine for HIVand the need for one is vastDespite the adv ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. DNA Based Nanoparticle Platform for HIV Env Presentation

    SBC: PARABON NANOLABS, INC.            Topic: NIAID

    In this projectParabon NanoLabs and The Scripps Research Institute propose to develop and produce an effective HIVvaccine using a structured DNA origami nanocarrier for the targetedcontrolled delivery of a stabilizedtrimeric HIVenvelope glycoproteinEnvwith an integrated adjuvantThe project will begin with the synthesis and characterization of composite nanostructurePV NFLto include development and ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. FAST-CMV: A Point-of-Care Cytomegalovirus Serodiagnostic and Avidity Assy

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: NIAID

    Congenital cytomegalovirusCMVinfection is the leading cause of permanent disabilitiescognitive impairmentand sensorineural hearing loss to newbornsMaternal infections that occur during pregnancy and symptomatic congenital CMV infections have been correlated with the most severe complicationsClinical trials are currently evaluating safety and immunogenicity of diverse vaccine candidates driven by t ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Nanvas TM (Oil in Water Nanoemulsion Adjuvant) Formulated Allergens as Intranasal Immunotherapeutic Vaccines for Peanut Allergy

    SBC: BLUEWILLOW BIOLOGICS INC            Topic: NIAID

    Food allergy is an emerging health problem with increasing incidence and severityparticularly in childrenand continuing throughout adulthoodSincethe incidence of self reported peanut allergy has risen significantly representing a mounting financial burden to the healthcare systemWith no approved therapeutics availablevarious forms of immunotherapy have been evaluated but generally do not facilitat ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Pediatric Opioid Withdrawal Research SystemPOWR System

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: ODCDC

    InoverAmericans died as a result of opioid overdosemaking opioid use the leading cause of death for Americans underThis crisis affects both males and femalesthus leading to a surge in the number of babies born with opioid addictionthe withdrawal from which is termed Neonatal Abstinence SyndromeNASIninstances of newborn opioid dependence were recordedDiagnostic metrics seek to standardize diagnosis ...

    SBIR Phase I 2019 Department of Health and Human ServicesCenters for Disease Control and Prevention
  6. Multiplex Detection of Recent and Prior Exposure to Pathogens

    SBC: LUNA INNOVATIONS INCORPORATED            Topic: ODCDC

    The goal of this project is to solicit the innovative development of diagnostic testing platforms that can simultaneously detect antigens of multiple pathogens and different antibody isotypes and or immune factors against those pathogens in a single multiplex assayThe pathogens of interest includebut are not limited tothose with a high potential for causing global disease outbreaks that affect vul ...

    SBIR Phase I 2019 Department of Health and Human ServicesCenters for Disease Control and Prevention
  7. SBIR PHASE II TOPIC 294:SITE-SPECIFIC ANTIBODIES FOR GLCNACYLATED PROTEINS IN CANCER; HHSN261201300058C; POP: 9/13/13-09/12/16; CAN: 8478363 IGF::OT::IGF OTHER FUNCTIONS

    SBC: DETROIT R & D, INC.            Topic: NCI

    O GlcNAcylation of proteins plays a critical role in cell cycle regulationapoptosis and signal transductionModification of O GlcNAcylation of proteins by O GlcNAc transferase is reversible by the activity of O GlcNAcaseAddition and removal of O GlcNAc moiety to serine or threonine regulate the function of proteins directly or via decreased phosphorylationO GlcNAcylation of c myc proteins induces u ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Development and evaluation of an all-in-one integrated webbased buprenorphine treatment program for opioid use disorder (Digital Interventions for Opioid Disorders- DIOD)

    SBC: WORKIT HEALTH INC            Topic: NIDA

    Workit Health will develop an automated system that helps clinicians organize and analyze patient dataPatients will express higher rates of treatment adherence in Medication Assisted Treatment in conjunction with psychosocial supportWorkit Health will conduct a randomized clinical trial that combines psychosocial support through CBT modules and peercounselor support and the DIOD program which adds ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. IMPACT-Instrument to Measure Pain and Assess Correlation to Treatment. Create a smartphone pupillometry to objectively determine the presence of acute pain, evaluate opioid as the treatment for pain.

    SBC: BENTEN TECHNOLOGIES, INC.            Topic: NIDA

    PROJECT SUMMARY ABSTRACT While patient self report of pain is currently the gold standard of pain measurementaccurate self reports of pain may not be feasible in critically ill patients who are sedated and intubatedunconscious patientsor patients who are unable to verbally communicate their painCurrent research has shown that pupillary dilationPDis a reliable indicator of acute painand that measur ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Healthy Close Relationships (HCR)- Mobile

    SBC: Research, Evaluation and Social Solutions, Inc. (REESSI)            Topic: NICHD

    ABSTRACT HEALTHY CLOSE RELATIONSHIPSHCRMOBILEGrowing up in under resourced environmentse gpovertylow incomegeographical isolationfragile family structurescan seriously threaten an adolescent s successful passage to adulthoodResearchers have uncovered very separate and unequal pathways to adulthood for adolescents one for thehavesone for thehave notsand a path for those who are in betweenThe networ ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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