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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Atmospheric Plasma Processing to Kill Pathogens and Extend Shelf Life of Produce


    DESCRIPTION (provided by applicant): This SBIR Phase I project will design, build, and test the Atmospheric Plasma Produce Disinfection System (APPDS), an in-line processing unit that will operate continuously to treat fresh produce. The APPDS will reducethe risk of foodborne infections by neutralizing pathogens, while decreasing microbial spoilage, preserving the organoleptic properties and nutri ...

    SBIR Phase I 2012 Department of Health and Human Services
  2. Germanium Gamma Cameras

    SBC: PHDS COMPANY            Topic: NIBIB

    DESCRIPTION (provided by applicant): Germanium gamma-ray imaging detectors will improve the quality of in-vivo molecular-imaging applications. The objective of this program is the development of the Germanium Gamma Cameras (GGCs) as modular component detector heads suitable for convenient integration into the molecular-imaging systems of other companies and research groups for small field-of-view ...

    SBIR Phase II 2012 Department of Health and Human Services
  3. Preclinical Development of a New Drug for Treating Anemia of Chronic Inflammation


    DESCRIPTION (provided by applicant): A strong unmet need exists to develop new treatments for anemias associated with chronic disease states, collectively referred to as anemia of chronic inflammation (ACI). ACI is highly prevalent in the U.S. and makes alarge contribution to public morbidity and mortality. Despite billions of dollars spent annually to treat ACI patients, current therapies lack e ...

    STTR Phase I 2012 Department of Health and Human Services
  4. A Universal Brain Atlas for Implanting and Managing Deep Brain Stimulators

    SBC: Neurotargeting, LLC            Topic: NIMH

    DESCRIPTION (provided by applicant): Deep brain stimulation has risen as a neurosurgical procedure of choice for patients with disabling neurological or psychiatric disorders for its abiliy to modulate improvement in the activity of certain circuits. The procedure is currently approved for treatment of Parkinson's disease (PD), essential tremor (ET), dystonia, and obsessive-compulsive disorde ...

    STTR Phase II 2012 Department of Health and Human Services

    SBC: INSIGHT GENETICS, INC.            Topic: NCI

    Constitutively activated forms of ALK caused by genetic aberrations have been shown to cause an expanding variety of human cancers. The FDA recently approved the Pfizer drug Xalkori (crizotinib) to treat patients with non-small cell lung cancers (NSCLC) that express ALK. Numerous other pharmaceutical companies (ARIAD, Novartis, Synta, Xcovery, others) have ongoing ALK small-molecule inhibitor pro ...

    SBIR Phase II 2012 Department of Health and Human Services

    SBC: INSIGHT GENETICS, INC.            Topic: NCI

    Lung cancer is the main cause of cancer mortality worldwide with 80% non-small cell lung cancer (NSCLC) in type and mainly driven by three mutually exclusive oncogenes, EGFR, KRAS and ALK (collectively between 30-60% of all NSCLC cases). Oncogenic driverssuch as ROS1 and RET fusions and DEPDC1 over-expression have been identified as clearly recurrent, collectively constituting up to ~12% of all NS ...

    SBIR Phase I 2012 Department of Health and Human Services
  7. Reducing Stroke by a Novel, Clot-dissolving Antibody

    SBC: Translational Sciences Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): Stroke is the 3rd leading cause of death and the primary cause of severe, long term disability. Each year 795,000 Americans have a stroke and the annual costs to the economy are 57.9 billion. The vast majority of acute ischemic strokes are caused by a thrombus (blood clot) which occludes the blood vessel and stops blood flow to the brain. Tissue plasminogen a ...

    SBIR Phase II 2012 Department of Health and Human Services
  8. Novel Methods for Dissolving Blood Clots

    SBC: Translational Sciences Inc.            Topic: NHLBI

    DESCRIPTION (provided by applicant): Each year, as many as 2 million Americans develop venous thromboembolism (VTE). VTEs are blood clots in the legs (venous thrombosis) that may travel to the lungs (pulmonary embolism). It is estimated that 10-20% of VTEpatients die, and the annual direct costs are up to 10 billion. Despite advances in diagnosis and prophylaxis, anticoagulation, a 50-year-old th ...

    STTR Phase II 2012 Department of Health and Human Services
  9. Molded Hydrogel Tympanic Membrane Repair Constructs

    SBC: GRACE MEDICAL, INC.            Topic: NIDCD

    DESCRIPTION (provided by applicant): Tympanic membrane perforations are commonly seen in otology practices and about 150,000 repair surgeries are performed each year in the United States. Current office-based procedures such as paper patch tympanoplasty are relatively ineffective or, like the irritant oil method, require multiple office visits. Surgical procedures including fascia and cartilag ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Development of an Atmospheric Plasma Applicator to Treat Chronic Wounds


    DESCRIPTION (provided by applicant): Annually, 5 to 7 million Americans are treated for chronic wounds that arise from diabetes, lower extremity arterial disease, lower extremity venous disease and edema, and pressure ulcers, and traumatic injuries, including burns. There is a real need for new advanced technologies to treat chronic wounds since a significant number of these wounds do not heal aft ...

    SBIR Phase I 2011 Department of Health and Human Services

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