Award Data

The threat of organophosphate (OP) chemical warfare agents (CWA) to United States military personnel is a persistent problem due to the relative ease of manufacturing chemical threats compared to nuclear and biological agents. Human butyrylcholinesterase (HuBChE) has been identified as a probable bio-scavenger of OP CWAs that could be used to protect individuals that could be exposed to OP CWAs. T ...

The threat of organophosphate (OP) chemical warfare agents (CWA) to United States military personnel is a persistent problem due to the relative ease of manufacturing chemical threats compared to nuclear and biological agents. Human butyrylcholinesterase (BChE) has been identified as a probable bio-scavenger of OP CWAs that could be used to protect individuals that could be exposed to OP CWAs. The ...

Organophosphorus (OP) toxins and chemical warfare agents (CWA) are active nerve agents posing significant hazard for both soldiers and civilians. Butyrylcholinesterase (BChE) is a safe and effective bioscavenger that detoxifies OP and CWAs when injected either prophylactically or post-exposure; but a major technical problem has been producing a recombinant form of BChE with acceptable properties f ...

A chemical threat agent mode of action is often initiated through a selective interaction with a biological molecule or structure. The agent binding mimics normal cellular processes, but then overruns natural control mechanisms leading to toxic and even lethal effects. The binding may be used as a basis for sensing the agent. By exploiting the native binding mechanism, a sensing element can be des ...

A chemical threat agent mode of action is often initiated through a selective interaction with a biological molecule or structure. The agent binding mimics normal cellular processes, but then overruns natural control mechanisms leading to toxic and lethal effects. The binding is used as a basis for sensing the agent. We are exploiting the native binding mechanism, designing and producing prototype ...

Development and production of semi-permeable and permselective polymer membranes can fill a critical need for standard reference materials for AVLAG, CBART, and IPE acquisition programs. Optimizing the permselectivity of tri-block copolymers to specific chemical agents, non-traditional agents, and toxic industrial chemicals and materials will result in the formation of suitable and affordable ref ...

"The Idaho Technology RAPID is currently the only fieldable DNA-based system available for monitoring threat agents such as Bacillus anthracis and Yersinia pestis. It has been deployed throughout the Air Force and other branches of the military with a highlevel of operational success. Typical PCR methods used with the RAPID are tied to complex wet chemistry more suitable for the laboratory than ...

"The Idaho Technology RAPID is currently the only fieldable DNA-based system available for monitoring threat agents such as Bacillus anthracis and Yersinia pestis. It has been deployed throughout the Air Force and other branches of the military with a highlevel of operational success. Typical PCR methods used with the RAPID are tied to complex wet chemistry more suitable for the laboratory than ...

Development of single use, freeze-dried PCR reagents for use with the Idaho Technology Ruggedized Advanced Pathogen Identification Device (RAPIDT system) or other commercially available real-time PCR devices is proposed. These reagents will have extendedstability at ambient temperature thus allowing sensitive PCR methods to be used in non-laboratory environments for the rapid detection of biologi ...

The ability to develop new technology on the basis of existing commercial technology can offer significant cost savings when compared to research programs to develop new technology from scratch. Continuing developments in mass spectrometry (MS), vacuum Systems and high speed gas chromatography (GC) sampling and analysis methods, have created an opportunity to fully demonstrate a powerful handporta ...