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DESCRIPTION (provided by applicant): PROJECT SUMMARY Congenital heart disease patients with functional single ventricle (FSV) anatomy ultimately require a Fontan operation for long term survival. The goal of the Fontan operation is to re-route systemic venous blood to the pulmonary circulation without passing through an intervening ventricular chamber. As a result, blood flow to the lungs is almos ...

DESCRIPTION (provided by applicant): This project aims to develop a novel system, Biolucida AT, which will greatly enhance the use of array tomography, the state-of-the-art method for investigating synaptic plasticity at the molecular level in human postmortem research and animal models of psychiatric, neurological and childhood developmental disorders. Synaptic transmission is essential for centr ...

This proposal was submitted under the Small Business Innovative Research (SBIR) Fast-track process. In Phase I, that concluded in September, 2014, the primary purpose was to develop a sensor-enhanced health information system for many different health contexts including prevention and management of chronic diseases such as cancers. In Phase II, Vignet will combine several innovative technologies a ...

To hijack the execution of a program, an attacker must overwrite the value of a return address or a function pointer (broadly defined). To prevent program hijacking, our product will provide a layered defense of these two targets, including deterministic and randomization defenses, with the ability in many cases to continue execution after a hijacking attempt is prevented. Our product toolkit incl ...

In order to better protect critical infrastructure from cyber attacks, perimeter and passive defenses must be complemented with an active defense mechanism which elevates the risks, or costs, a potential attacker will face. The effectiveness of an active defense mechanism, however, is ultimately limited by its ability to detect threats fast, accurately, and reliably. For this Phase II project, we ...

Existing information extraction technology can only partially address the problem of exploiting unreadably-large amounts text. When discussion of events is limited to simple, past-tense, factual descriptions of events, current NLP-based systems can ident

Deployment of unmanned systems continues to expand across a wide range of missions; for example, logistics and resupply missions, force application and protection, and improving battlespace awareness. Presently these unmanned systems run at the lowest of four possible levels of autonomy, that is, in a teleoperated mode, and each system typically requires multiple operators. To address this proble ...

In DoD systems a large number of software systems are embedded in a single platform. In the proposed research the ability to determine simultaneously the optimal allocation of resources and the associated configurations for multiple hardware/software systems will be developed in the DS Toolkit. The MDO algorithms of the Toolkit enable the new developments due to their abilities to balance decisi ...

DESCRIPTION provided by applicant Advances in DNA sequencing technology have now made it practical and affordable to generate datasets containing millions of genetic attributes that can be tested for association with disease susceptibility The computational complexity of searching for genetic interactions over such high dimensional datasets imposes great challenges for genome wide associatio ...