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Award Data

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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Long Term Behavior, Failure Analysis & In-Service Testing of Composite Cylinders

    SBC: Texas Research Institute, Austin, Inc.            Topic: 101PH1

    TRI proposes to develop reliable methodology and protocols for in-service inspection,recertifying and retiring DOT COPVs to maximize service life while ensuring personnel safety. This method must be sufficiently robust to prevent in-service failures, while being straightforward and affordable enough to be conducted at cylinder recertification facilities. To accomplish this with a high degree of co ...

    SBIR Phase I 2011 Department of Transportation
  2. Development of a non-destructive, quantitative residual stress assessment tool

    SBC: Generation 2 Materials Technology Llc            Topic: 111PH2

    A nondestructive tool will be developed to quatitatively assess residual stress in pipelines from the exterior and through coatings. Residual stress is a critical factor that determines the cracking susceptibility of pipeline steels, but existing methods for measuring mechanical damage in pipeline steels are incapable of quantifying the residual stress levels. A larger gouge or dent does not nec ...

    SBIR Phase I 2011 Department of Transportation
  3. Rapid screening tool for antibiotic resistant pathogens

    SBC: Resonant Sensors Incorporated            Topic: NIAID

    DESCRIPTION (provided by applicant): The innovation presented in this proposal is a new class of label-free biochemical sensors with applicability in point of care (POC) medical diagnostics. The goal of the project to develop commercial biochip systems with compelling performance metrics targeted for rapid screening of an array of antibiotic resistant microbials in a clinical setting. The biochips ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. HEPylated G-CSF: Drug with Safer, Enhanced Delivery for Neutropenia Treatment

    SBC: CAISSON BIOTECH, LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Poly[ethylene glycol] (PEG) polymers are widely used by pharma to enhance the physical, chemical, and/or biological nature of promising drug candidates. The process of adding PEG polymers to drug cargo is termed PEGylation and has resulted in several Billion/year drugs. PEGylation protects the cargo when in the body and prolongs therapeutic action. For patient ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. Novel Small Molecules for Treating Kidney Disease

    SBC: CRO LABORATORIES, INC.            Topic: NIDDK

    DESCRIPTION: Chronic kidney disease (CKD) is a significant and rapidly growing global health crisis. CKD is associated with cardiovascular disease, hypertension, diabetes, obesity, and aging. It is characterized by gradual loss of renal function with increasing proteinuria (albuminuria), interstitial fibrosis, and glomerulosclerosis. Small increases in urinary protein are associated with markedly ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. Microvascular Functional Imaging System

    SBC: Visionquest Biomedical LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): VisionQuest Biomedical and the University of New Mexico (UNM) Health Science Center have formed a team to implement and demonstrate a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy. This team will develop and test the Microvascular1Functional Imaging System (MFIS), ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Field Deployable Vapor Intrusion Monitor

    SBC: Lynntech Inc.            Topic: NIEHS

    DESCRIPTION (provided by applicant): Vapor intrusion is the migration of volatile chemicals from the subsurface into overlying buildings, one of the major causes for a large population exposure to hazardous chemicals. These volatile chemicals are often theresult of buried waste and/or contaminated groundwater that can emit vapors that may migrate through subsurface soils and into indoor air spaces ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. Optoacoustic system for monitoring biodistribution of nanoparticles in vivo.


    DESCRIPTION (provided by applicant): We propose novel application of optoacoustic tomography for non-invasive and quantitative analysis of nanoparticle biodistribution in preclinical research. Novel nanotechnology-based treatments of cancer and other diseases with increased specificity and enhanced therapeutic potential are being actively developed at present. There is a pressing need for low-cost ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. New Reagents for the Synthesis of Phosphorodithioate-Modified 2'-O-Methyl RNAs


    DESCRIPTION (provided by applicant): Functional RNA molecules such as aptamers, siRNAs, miRNAs, and related compounds have enormous potential as human therapeutics and as tools for elucidating gene regulation in vivo. To reach this potential, such molecules must be highly potent and highly nuclease resistant. Unmodified RNAs typically do not meet these requirements. A variety of chemical modificat ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Development of a novel assay for the analysis of newly synthesized RNA


    DESCRIPTION (provided by applicant): While changes in mRNA decay rates account for approximately 50% of the regulation of gene expression in the cell, an assay to accurately and reliably measure mRNA half lives is currently not available. In particular, the deficiency of reliable commercial kits which enable the average biomedical research lab to effectively investigate mRNA decay rates is signifi ...

    SBIR Phase I 2011 Department of Health and Human Services
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