Award Data

DESCRIPTION (provided by applicant): Founded in 1999, Adenosine Therapeutics LLC (ATL) is a drug discovery and development company that has developed a family of potent and selective adenosine A2A receptor agonists. With the help of STTR funding, ATL has developed a lead adenosine A2A receptor agonist, ATL-146e, that is currently in late Phase II of clinical development for use as a coronary vaso ...

DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) accounts for approximately 40% of the cases of renal failure requiring dialysis or transplantation. Moreover, diabetic nephropathy is associated with markedly higher morbidity and mortality rates. It is important to develop novel interventions to prevent complications of diabetes. Inflammation in the genesis of diabetes, as well as its ...

DESCRIPTION (PROVIDED BY APPLICANT): Selective antagonists of A2A adenosine receptors have proven to be effective for the treatment of Parkinson's disease (PD) both in animal models and in a human trial. However, the initial clinical trial was stopped in phase 3 due to detection of animal toxicity of KW6002. Other investigational compounds lack sufficient potency, selectivity or bioavailability to ...

DESCRIPTION (provided by applicant): We propose an innovative approach combining two separate, novel techniques to greatly enhance accurate detection of leukemia or lymphoma cells, which can be used ultimately for diagnostics and early detection of minimal residual disease (MRD) in bone marrow, lymph nodes, and peripheral blood. The novel techniques of our approach are: (1) A two-step method to ge ...

DESCRIPTION (provided by applicant): Acid-prepared mesoporous silica ("APMS") shows significant advances over commercially available silica in high performance liquid chromatography ("HPLC"), a technique commonly used to isolate molecules. HPLC columns containing APMS show dramatically enhanced molecular retention times and improved peak-to-peak resolutions compared to commercial HPLC columns. The ...

DESCRIPTION (provided by applicant): The overall objective of the proposed cooperative research and development project is the implementation and validation of an advanced instrument tracking technology to be used by the surgeon, the radiologist, the gastroenterologist, and other physicians to better enable image-guided cancer treatment, through these specific aims: Specific aim 1: Ascension ...

DESCRIPTION (provided by applicant): Blind and visually impaired people do not have full access to the technology offered by cellular telephones today. Most cell phones rely upon visual displays to relay or communicate information. The lack of a text-to-speech program integrated into cellular telephones, excludes the blind and visually impaired from interactively and independently utilizing this s ...

DESCRIPTION (provided by applicant): Barren Associates, Inc. proposes to develop the Telecare (TLC) home monitor, a system targeted for use by physicians and home service providers that care for elderly individuals. The TLC monitor will track the frequency of occurrence of fall and near-fall episodes, document fall characteristics (e.g., impact location and impact energy), and identify circumstan ...

DESCRIPTION (provided by applicant): Noninvasive and unobtrusive instrumentation is needed to monitor individuals in clinical and natural settings for such purposes as monitoring for medication side effects, monitoring post-operative and chronic patients, and for diagnosing and treating various disorders. Example disorders include sleep problems (e.g., sleep/wake patterns; sleep quality, quantity ...

DESCRIPTION (provided by applicant): Abstract: Autoimmune diseases and older people with weakened immune system are a major public health problem; for example, there are about 2 million individuals with RA, i.e. about 1 % of population of USA. Similarly, there are millions of older people with cardiovascular diseases. Better information is needed about the immunoprofiles of older persons. The ...