Award Data

DESCRIPTION (Scanned from the Applicant's Abstract): The specific aim of this esterase (CE) inhibitor in an acute cholesterol absorption assay. Hamsters will be gavage fed 3H-labeled cholesterol with CE-inhibitor ranging from 20-200 umoles. Twenty-four hours later, hepatic and serum cholesterol absorption will be assayed. Hepatic and serum cholesterol levels will be det ...

Certain weapons produce blast waves capable of trauma to gas-filled organs. There is an immediate need for a blast mitigation jacket to prevent lung damage when training with such weapons, and a similar need for combatants. Our first objective in PhaseII is to complete the research and development of fundamental blast mitigation concepts developed during Phase I. During Phase I, we used analyti ...

Certain weapons produce blast waves capable of trauma to gas-filled organs. There is an immediate need for a blast mitigation jacket to prevent lung damage when training with such weapons, and a similar need for combatants. Our first objective in PhaseII is to complete the research and development of fundamental blast mitigation concepts developed during Phase I. During Phase I, we used analyti ...

DESCRIPTION (provided by applicant): The purpose of this Phase I project is to design and pilot test the feasibility of the first set of lessons in a comprehensive program to enable staff and students in junior high schools to create safe, supportive learning communities in the school and to enable students to learn the necessary skills to maintain that envi ...

Virilizing congenital adrenal hyperplasia (CAH) describes a group of disorders of steroidogenesis involving the pathway from cholesterol to cortisol. Ninety-five percent of CAH results from alteration of the CYP21 gene. The salt wasting form of CAH may be fatal in the neonatal period while non-classical forms cause health problems late in life. Screening for CAH involves measuring 17-hydroxyproges ...

FSCX will develop a methodology and system design that will lead to a Phase II SBIR prototype, which will provide automated, decision support products to improve collective performance in training and real world operations. The prototype will improveindividual and collective understanding in information intensive, digital environments. FSCX calls this prototype SpectoAgnito, a coined term meanin ...

DESCRIPTION (provided by applicant): The diagnosis of systemic lupus erythematosus is a serious public health problem. Almost 90 percent of the 2,000,000 people who have been told that they have lupus do not fulfill the diagnostic criteria to classify a person as having lupus. The laboratory test used to screen for lupus is largely ...

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DESCRIPTION (From the Applicant's Abstract): Prior to surgery the donor cornea is screened for a number of pathologies and its history is examined for contra-indicated events, including the application of refractive surgery. Current techniques, such as topological measurement, produce significant errors, resulting in rejection of viable ...