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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. SMALL MOLECULE THERAPY FOR ALZHEIMER'S DISEASE

    SBC: Recombinant Technologies LLC            Topic: NIA

    DESCRIPTIONprovided by applicantAlzheimer s diseaseADrepresents a progressive degenerative illness that affects the brainresulting in memory impairmentThe complex etiology of AD is not fully resolvedalthough toxic isoforms of amyloidAplaques are strongly implicatedCurrent treatment options are considered to be symptomaticThey are only moderately effective in stabilizing or improving cognitive and ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria

    SBC: VisionQuest Biomedical Inc            Topic: NIAID

    DESCRIPTION provided by applicant Cerebral malaria CM is a life threatening neurological complication associated with malarial infection Malaria affects about million people worldwide and claims lives annually of whom are African children under years of age CM is mistakenly over diagnosed about of the time in which the cases of concurrent non CM diseases with simil ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. Novel Androgen Receptor Degraders to Treat Castration Resistant Prostate Cancer

    SBC: Arvinas, Inc            Topic: 102

    DESCRIPTION provided by applicant The overall aim of this grant is to generate data to understand and enable the development of a novel therapeutic approach for the treatment of patients with castration resistant prostate cancer Prostate cancer is the third most lethal cancer in the US with new cases and deaths projected to occur in While early detection surgery and horm ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. Kinome wide Cell Based Assays

    SBC: LUCEOME BIOTECHNOLOGIES, L.L.C.            Topic: 300

    DESCRIPTION provided by applicant The human genome encodes protein kinases that catalyze the phosphorylation of client proteins Signal transduction mediated by protein impacts virtually all aspects of cellular physiology from the coordination of the cell cycle and cll division to apoptosis Not surprisingly the deregulation of kinases is implicated in many diseases including diabetes in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. A high volume parallel acoustic flow cytometer for the detection of rare cells or particles in a large sample volume with a low background concentration i e very dilute samples

    SBC: ETA DIAGNOSTICS, INC            Topic: 400

    DESCRIPTION provided by applicant Many biomedical applications require the detection of rare cells or particles in large sample volumes These applications can be divided into those that require the detection of highly dilute cells in a large sample volume and those that require the detection of rare cells in a high background concentration of similar cells within a large volume Though flow cy ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  6. A Virtual Learning World for Tweens to Experience Possible Selves (ME GAMES)

    SBC: Research, Evaluation and Social Solutions, Inc. (REESSI)            Topic: 102

    DESCRIPTIONprovided by applicantThe word adolescence derives from the Latin word "adolescere"meaning"to grow up"Adolescence is a crucial period of transition between childhood and legal adulthoodwith individuals following more uncertain and complex paths based on genderraceethnicitysocial classand geographyThe passage to adulthood revolves around a complex web of factorswhich include socialsocioec ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Software and hardware to study brain function during behavior using laser scanning microscopy.

    SBC: Vidrio Technologies, LLC            Topic: 105

    The past decade has seen major advances in the tools available to neuroscientistsmaking it possible to ask increasingly specific questions regarding which neurons and circuits are correlated withnecessary forand sufficient forspecific behavioral or computational functionsTwo photon laser scanning microscopyTPLSMis a widespread tool that allows three dimensional imaging and photo stimulation deep w ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Sustained release gel enabling one stage treatment of prosthetic joint infection

    SBC: SONORAN BIOSCIENCES INC            Topic: NIAMS

    Principal Investigator Overstreet Derek J Abstract Sonoran Biosciences Inc SBIR PAR Direct Phase II Prosthetic joint infections PJIs are especially costly requiring two surgeries at a cost of approximately $ per case to treat more than hip and knee replacement infections each year The near term outlook in this area is bleak with the number of infections growing ov ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Allosteric MIF Inhibitors for Rheumatoid Arthritis Therapy

    SBC: L2 DIAGNOSTICS LLC            Topic: NIAMS

    Abstract The long term product goal of this project is a small molecule rheumatoid arthritis RA therapeutic which acts by reducing the inflammatory response triggered by the pro inflammatory cytokine macrophage migration inhibitory factor MIF The therapeutic benefit of MIF inhibition in RA disease models has been well established by small molecules that bind to a catalytic site of the MIF tri ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Validation of a human in vitro system of hepatic steatohepatitis

    SBC: HemoShear Therapeutics, LLC            Topic: 300

    Phase II SBIR Validation of a human in vitro system of hepatic steatohepatitis ABSTRACT Non alcoholic steatohepatitis NASH is part of the progressive disease spectrum of non alcoholic fatty liver disease NAFLD a public health crisis affecting of type diabetics and of obese individuals Glucose and insulin regulated de novo lipogenesis in the liver a critical step in the disease ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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