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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Photostable Fluorescent Probe For Imaging Live Cells Alternative To Quantum Dot

    SBC: ABD BIOQUEST, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Since the earliest examination of cellular structures, biologists have been fascinated by observing cells using light microscopy. The advent of fluorescent labeling technologies plus the plethora of sophisticated light microscope techniques now available make studying dynamic processes in living cells almost commonplace. The ability to visualize, track, and qu ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  2. Nutrition Initiative for Small Chain Restaurants (NISCR)

    SBC: ACCENTS ON HEALTH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Nutrition Initiative for Small Chain Restaurants (NISCR) Project Summary/Abstract To help combat obesity and diet-related diseases prevalent in the U.S., the proposed project will develop a program that enables and enco urages small chain restaurants to (1) serve a selection of healthier menu items and provide corresponding nutrition information and (2) promo ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  3. Electron Spin Resonance Microanalyzer

    SBC: Active Spectrum, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): Electron spin resonance spectrometry is a widely used technique for the detection of free radicals and paramagnetic centers. There are over 23,000 published biomedical research papers citing this technique, particularly the use of spin labeling and measurement of reactive oxygen species and reactive nitrogen species. However, applications of electron spin reso ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  4. A small molecule screen to target viral RNA-protein complexes

    SBC: ADVANCED GENETIC SYSTEMS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There is a significant need for novel HIV therapies given the emergence of viruses resistant to existing drug regimens. RNA-protein complexes represent an important and under utilized drug target. In HIV, the Tat-TAR an d Rev-RRE RNA- protein complexes carry out essential roles in RNA transcription and nuclear export respectively. Disruption of these RNA-protei ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Sub-second 3D Pulse Sequences for FMRI in Neurosciences

    SBC: ADVANCED MRI TECHNOLOGIES LLC            Topic: N/A

    DESCRIPTION (provided by applicant): MRI is a proven non-invasive technique to make functional MRI (fMRI) by measuring changes in blood oxygen level dependent (BOLD) contrast in different regions of the brain resulting from the neurovascular coupling of neuronal activity. Echo planar imaging (EPI) is the most widely used fMRI pulse sequence, due to its speed and BOLD contrast, however EPI has r ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  6. Inhibition of Neurotransmission in Specific Neuronal Populations

    SBC: Advanced Targeting Systems            Topic: N/A

    DESCRIPTION (provided by applicant): In extensive work over the last decade, it has become clear that biologically active molecules can be inserted into specific cell types through targeting to molecules on the cell surface. It is here proposed to direct this technology to specific neuronal cell types with the purpose of temporarily inhibiting their capacity of releasing neurotransmitters. As pr ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  7. Microneedle patches deliver a CGRP antagonist for neurogenic inflammatory pain

    SBC: AFASCI, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Recent surveys indicate that approximately 26 - 27 million individuals in the US suffer from moderate to severe chronic pain. A key pathophysiology of chronic pain is neurogenic inflammation, which is primarily elicited by activation of unmyelinated sensory neurons through noxious stimuli and the subsequent release of neuropeptides such as calcitonin gene-rela ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  8. Development of E64d for Alzheimer's disease

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). The abnormal accumulation of neurotoxic brain ss-amyloid peptides (A?) is thought to be a possible cause the disease. A? are p roduced by proteolytic cleavage of a larger amyloid precursor protein by proteases, called ?- and ?-secretases. Inhibiting 2-secretase cleavage ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  9. Development of protease inhibitor drugs to treat Alzheimer's disease

    SBC: AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): There currently is no drug available that stops the progression of Alzheimer's disease (AD). Neurotoxic ?-amyloid peptides (A??) are thought to cause the disease with their accumulation in brain plaques being a hallmar k. A? are cleaved from a larger amyloid precursor protein (APP) by proteases, called ?? and ?-secretases. Compounds that inhibit ?-secretase ma ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Approach to Enhance Cord Blood-Mediated Bone Marrow Homing and Engraftment

    SBC: TARGAZYME, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Despite significant recent government and private-sector efforts to improve the current state of the art in bone marrow transplants, many patients still suffer from lack of adequate matching bone marrow inventories and from severe treatment-related complications. Key drawbacks to conventional approaches include the major delays in finding compatible donors and ...

    SBIR Phase I 2008 Department of Health and Human ServicesNational Institutes of Health
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