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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A Topical Nasal Gel as an Invisible Shield Against Viral and Bacterial Pathogens

    SBC: ICET, INC            Topic: NIDILRR

    This SBIR project develops and evaluates a topical nasal gel that serves as an invisible shield against viral and bacterial pathogens, which may lead to respiratory infections in individuals with spinal cord injury (SCI). Respiratory infections leading to pneumonia remain the most common cause of mortality for approximately 30 to 70 percent of the SCI population. SCI patients are most vulnerable t ...

    SBIR Phase I 2020 Department of Health and Human ServicesAdministration for Community Living
  2. Nanotrap particle viral enrichment technology for enabling portal, next-generation sequencing-based surveillance

    SBC: CERES NANOSCIENCES            Topic: NCIRD

    PROJECT SUMMARY RNA viruses, such as influenza and the Ebola virus, have been classified as the greatest threat for causing a global pandemic given their high mutation rates and abilities to jump between host species. National and global agencies have called for research and development efforts to improve RNA virus surveillance capabilities. While the tools for surveilling DNA viruses have advance ...

    SBIR Phase I 2020 Department of Health and Human ServicesCenters for Disease Control and Prevention
  3. Factory Noise Removal to Preserve Situational Awareness

    SBC: Speech Technology and Applied Research Corporation            Topic: NIOSH

    Abstract According to the CDC NIOSH website “Occupational hearing loss is one of the most common work- related illnesses in the United States.” This is due, in part, to significant numbers of workers exposed to hazardous noise levels in the workplace not using hearing protection devices (HPDs). A National Health and Nutrition Examination Survey estimated that over 20 million U.S. workers are e ...

    SBIR Phase I 2020 Department of Health and Human ServicesCenters for Disease Control and Prevention
  4. Wearable Device for Automatic Delivery of Naloxone during Respiratory Arrest due to Opioid Overdose

    SBC: BIOSENSICS LLC            Topic: NIDA

    Abstract The United States is experiencing an epidemic of opioid use, which has been declared as a national emergency. During an overdose, the respiratory centers in the brain are suppressed. This leads to dangerous lowering of blood oxygen levels, loss of consciousness, and eventually respiratory arrest and death. There are many initiatives to reduce the death rate from opioid overdosing includin ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  5. Prodrugs and Derivatives of Hydroxymethylfurfural (5-HMF) to Develop a Novel, Bioavailable Treatment for Sickle Cell Disease

    SBC: IllExcor Therapeutics LLC            Topic: NHLBI

    In this SBIR Phase I project, IllExcor Therapeutics proposes the development and evaluation of novel prodrug therapeutics as a yet untapped approach to treat sickle cell disease (SCD), a hereditary malady involving a single point hemoglobin (Hb) mutation that leads to severe adverse physiological complications culminating in painful vaso-occlusive crises, chronic endothelial damage, and progressiv ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  6. Improving the clarification, characterization, and homogeneity of animal serum through Nanotrap nanoparticle technology

    SBC: CERES NANOSCIENCES            Topic: 400

    PROJECT SUMMARY SARS-CoV-2 is the β-coronavirus causing the current coronavirus disease 2019 (COVID-19) outbreak. Large- scale diagnostic testing and large-scale screening are key tools used to contain outbreaks, and are especially important for something as transmissible as SARS-CoV-2. While various clinical specimens—like blood, pharyngeal swabs, saliva, anal swabs, and urine—have showed th ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Optical probe for in situ assessment of pulmonary fibrosis

    SBC: PHYSICAL SCIENCES INC.            Topic: NHLBI

    Project Summary/AbstractPhysical Sciences Inc. (PSI), in collaboration with the Department of Pathology at the Massachusetts General Hospital (MGH) and the Divisions of Pulmonary and Critical Care Medicine at MGH and Beth Israel Lahey Health (BILH), proposes to develop and evaluate a novel technology for assessing pulmonary fibrosis, which is a respiratory disease leading to serious breathing prob ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  8. Optical Redox Probe for Continuous Metabolic Monitoring during Natural Products Bioprocessing

    SBC: PHYSICAL SCIENCES INC.            Topic: NCCIH

    Project Summary/AbstractNatural products including polyketides, fatty acids, amino acids, terpenoids and steroids, are playing an increasingly important role in the pharmaceutical industry. Though many of the natural products are discovered in plants, mass production of these molecules relies on culturing microorganisms in bioreactors. However, it is often a challenge to develop and maintain high ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Ultra-Sensitive Vapor Phase Hydrogen Peroxide Sensor for Decontaminating Pharmaceutical Manufacturing Facilities and Equipment

    SBC: PHYSICAL SCIENCES INC.            Topic: 400

    Project Summary/AbstractPhysical Sciences Inc. (PSI) proposes to develop an ultrasensitive laser-based sensor to accurately monitor ppbv to ~1000 ppmv concentrations of vapor phase hydrogen peroxide (VHP) following decontamination of parenteral drug manufacturing facilities where biologic and cellular therapeutics must be packaged under aseptic conditions. The capability to accurately and sensitiv ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
  10. Discovery of Enterovirus D68 2A protease inhibitors for antiviral therapy

    SBC: MICROBIOTIX, INC.            Topic: NIAID

    Abstract Enterovirus D68 (EV-D68), a highly contagious non-polio enterovirus, caused the 2014 outbreak affecting thousands of people in multiple countries, including the US, Canada and Europe. Historically, symptoms of EV- D68 infections include rhinorrhea, muscle aches and cough. However, during the 2014 outbreak, there were increasing cases involving more severe respiratory symptoms and hospital ...

    SBIR Phase I 2020 Department of Health and Human ServicesNational Institutes of Health
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