Award Data

"21st Century Systems, Inc. (21CSI) proposes to continue its research and realization of an agent-based decision support system, EXLOG21, for logistics and maintenance operations. In Phase I we researched the base theoretical underpinnings for expeditionarylogistics and constructed a convincing autonomic logistics (AL) system prototype (interfaced to a notionally simulated subset of an instrumente ...

"In response to Small Business Innovative Research solicitation BMDO02-016, 21CSI is pleased to propose the development of a proof-of-concept sensor intranet and decision aid software application that ties disparate and legacy sensors into a net. Ourconcept, Sensor-AEDGE, will be built from the bottom up to support the netting of sensors into a cohesive, complementary unit. It will employ intell ...

DESCRIPTION (provided by applicant): Phenylketonuria (PKU) is a genetic deficiency of phenylalanine hydroxylase (PAH). Without PAH, the patient with PKU cannot metabolize phenylalanine (PHE) to tyrosine. The resulting accumulation of PHE and the accumulation of phenylpyruvate by a secondary metabolic pathway in the patient's blood produce neuropathies including severe mental retardation, behavior ...

The accurate measurement of blood glucose concentration is important in the management of diabetes. Current methods of glucose monitoring involve piercing the skin and collecting blood samples for analysis up to four times daily or more. Even the non-invasive Glucowatch tm glucose monitoring system requires twice daily blood collection for calibration. This original, innovative invention will decr ...

"Adequate hearing protection for U.S. Navy crew personnel is mandatory and may be achieved through the use of earcups, earplugs, or both. Donning only the earcups or only the earplugs is referred to as single hearing protection (SHP), while the use ofearplugs under earcups is called double hearing protection (DHP). This Phase I program offers a comprehensive engineering study and design strategy ...

"The design, development and testing of a real-time audio telepresence device for remote acoustic monitoring is proposed. The primary goal of the Phase I effort is to deliver a fully functional wired binaural prototype microphone capable of delivering themost realistic hearing capabilities to a remotely located soldier. The technical objectives and work tasks focus on building and testing the pr ...

"The extreme noise fields encountered by U.S. Navy flight deck and cockpit crewmen interfere with speech intelligibility and cause hearing loss to warfighter personnel, even with the currently-fielded communication systems. This Phase I program willdevelop new active noise reduction (ANR) technologies and improve existing passive technologies for incorporation into a prototype double hearing prot ...

DESCRIPTION (provided by applicant): The development of new treatments for the effective reduction of renal injury associated with acute renal failure and kidney transplantation will have a great impact on health care delivery to patients with renal disease. Acute ischemic renal failure affects 5 percent of hospitalized patients and has a mortality rate approaching 50 percent. At present, dialysis ...

DESCRIPTION (provided by applicant): This project develops A2A adenosine receptor (A2AAR) agonists as adjuncts to antibiotics for the treatment of anthrax septicemia. It responds to the urgent need for better treatment of highly lethal infections by this bioterrorism/biowarfare agent. Phase I has two aims, pharmaceutical development and documentation of efficacy in clinically relevant settings. Th ...

epsis syndrome is the 11th leading cause of death in the United States ( about 900,000 new cases per year) with a mortality of about 35 percent. The need for adjunctive therapies is urgent. In Phase I of this SBIR award we documented the anti-inflammatory effects of adenosine A2A receptor (A2AAR) agonists on isolated immune cells and have observed ramatically improved survival in mouse models of I ...