Award Data

Spinal Cord Injury (SCI) is a devastating condition for which there is no effective treatment. The cost to society is enormous because most new cases occur in people under the age of 30 and these individuals have a near normal life expectancy. Therefore, the development of a new, effective therapy to treat SCI is imperative. We propose to use an established in vitro assay to screen antisense molec ...

The goal of this project is to conduct pre-clinical tests of components of the extracellular matrix molecule tenascin-C that offer potential as therapeutics for enhancing nerve fiber regeneration. This may lead to the development of a treatment for spinal cord injury, a devastating condition for which there are no reparative treatments available. The study is based on ...

DESCRIPTION (Scanned from the Applicant's Abstract): Blockade of A2B adenosine receptors (A2BARs) increases insulin sensitivity in insulin resistant obese Zucker rats by an effect on skeletal muscle. We have synthesized and characterized the first potent and selective antagonists of A2B receptors. The goal of this phase I SBIR proposal is to develop improved A2 ...

DESCRIPTION: (Adapted from the Investigator's Abstract): Adenosine administered as an aerosol to asthmatics causes bronchoconstriction, while in non-asthmatics adenosine causes bronchodilation. This occurs because the activation of A2B adenosine receptors on sensitized mast cells triggers degranulation, releasing histamine, leukotrienes, and other allergic mediators. A2B a ...

The purpose of this research is to develop and test the feasibility of a novel portable computerized system that will enable nursing assistants to provide improved patient care. The system will enable nursing assistants to work more efficiently, record data more accurately, and spend more time with each patient. The system is being designed for use in assisted living facilities and nursing home ...

65507 Adhesive systems are needed for the assembly of detectors for high-energy physics applications, especially an adhesive that cures upon the application of an external stimulation, such as UV light. However, the end use of these detectors requires extensive shielding to protect the detectors from impinging stray light that might interfere with the small responses generated during subsequent ...

65544 Nuclear physics research requires large detectors that can detect particles with good spatial and time resolution. However, these devices are expensive to build and require high maintenance. They also require a large solid support structure, which adds to overall project cost. This project will integrate a new scintillator material into a fiber-optic-based array to produce a high-resolut ...

Large space-deployed structures such as synthetic aperture radars, radiometers, and solar arrays are receiving a great deal of interest by NASA in the Earth Sciences program. These large structures by necessity must be ultra-lightweight and low stored volume. Inflatable or self-deployable approaches that become rigid after they reach the correct shape appear to be a promising approach for fabricat ...

65437 In closed waste-storage systems containing either easily oxidizable metals or radioactive materials, molecular hydrogen is produced. If these closed containers have hydrogen impermeable shells or cases, the build-up of hydrogen gas may form an explosive or flammable mixture with any contained air. It may also present a corrosion problem for certain reactive metal elements that tend to for ...

65532 The recycling of mixed or contaminated plastic could save energy. However, the products of most recycling processes used today are of low quality and represent only a shifting of the problem by one product generation. This project will adapt an existing technology for the recycling of polystyrene waste from food service operations with the recovery of monomers and other valuable raw mater ...