Award Data

DESCRIPTION (provided by applicant): Advancement in wound management or tissue repair has been limited by the complexities, costs and limited efficacy of purified recombinant growth factors. Further, the combination of these recombinant proteins for moresophisticated approaches is complicated by the need for separate biologics. Optimally, we can move to a single biologic DNA pro-drug that provide ...

DESCRIPTION (provided by applicant): VisionQuest Biomedical and the University of New Mexico (UNM) Health Science Center have formed a team to implement and demonstrate a thermal-optical imaging system for detecting and quantifying neuronal and microvascular dysfunction associated with peripheral neuropathy. This team will develop and test the Microvascular1Functional Imaging System (MFIS), ...

DESCRIPTION (provided by applicant): Antiscatter grids currently employed on fluoroscopic systems are limited in their capability to control scatter. As a result, fluoroscopic radiation levels are higher for the average patient than they would be with a more efficient grid system, and higher still for large patients. Poor image quality often increases the beam-on time required to successfully perf ...

DESCRIPTION (provided by applicant): Central vision field loss (CFL) is caused by inherited and acquired diseases that irreversibly damage the fovea while leaving the peripheral retina relatively intact. CFL results in 1,700,000 legal blindness and lowvision (LV) cases in the US. LV rehabilitation is the means of restoring functional abilities modified by CFL so that the patient's quality ...

DESCRIPTION (provided by applicant): Membrane proteins are an essential component of intercellular signaling pathways. The overwhelming majority of small molecule drugs, either directly or indirectly, target membrane proteins. Arrays of membrane proteins would be important tools in drug screening and academic research laboratories in studies of interactions between proteins and lipids, proteins an ...

DESCRIPTION (provided by applicant): Research using Xenopus (frog) embryos, a model system of major importance in many areas of biomedicine, is hampered in a fundamental way by their opacity. No device for non-destructively imaging the interiors of these specimens is generally available. The long-term goal at ABQMR, Inc. is to utilize unique capabilities in the field of miniaturized NMR and MRI in ...

DESCRIPTION (provided by applicant): The wraparound service model (WSM) is an individualized care planning and management process for children and youth with serious emotional and behavioral disorders (SEBD) that is implemented in nearly 1000 sites in theUnited States. The purpose of this Phase I Small Business Technology Transfer (STTR) proposal is to develop and pilot test a web-based monitoring ...

DESCRIPTION (provided by applicant): This Phase II project continues the successful Phase I discovery of novel decorporation agents that are selective for radioactive strontium (Sr). This project consists of the necessary steps for submission of an Emergency Use Authorization (EUA) or Investigational New Drug (IND) application to the US FDA. A goal is to have orally- administered, GI-chelation for ...

DESCRIPTION (provided by applicant): DiscoveryBioMed, Inc. (DBM) achieved Phase 1 SBIR milestones and seeks to continue a mature program that has progressed to the hit-to-lead drug validation, prioritization and progression stage. DBM s major over-archinggoal for this program is to identify novel clinical candidate CFTR Corrector Ligands (CFCLs) for the treatment of CF through the completion of a ...

DESCRIPTION (provided by applicant): Temporomandibular Disorders (TMD) represent a collection of medical and dental conditions affecting the temporomandibular joint (TMJ) and/or the muscles of mastication, as well as contiguous tissue structures. For somepatients with severe TMJ degeneration, a prosthetic replacement may be required. However, long-term success and functioning of current implant d ...