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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Ultra-High Efficiency Ethylene Scrubber to Reduce Cold Storage Costs of Produce

    SBC: Sonata Scientific            Topic: 813

    The importance of improving postharvest handling can be understood in terms of the primary impact of poor postharvest care--food loss. Technologies for improving postharvest handling focus on extending the shelf life of the fruit or vegetable while maintaining or improving upon the quality of the produce. A major achievement in prolonging produce storage life has been the implementation of cold st ...

    SBIR Phase I 2018 Department of Agriculture
  2. Fate and Fortune: A Story-Based Algebra Simulator of High Seas Trade

    SBC: MidSchool Math, LLC            Topic: 99190018R0005

    Purpose: This project team will fully develop and test Fate and Fortune, an online class-wide intervention where grade 8 students learn algebra within a story-based game. Research demonstrates that students who do not succeed in algebra are more likely to eventually drop out of high school. When students begin Algebra I, a lack of conceptually meaning and understanding can be further reinforced by ...

    SBIR Phase II 2018 Department of EducationInstitute of Education Sciences
  3. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. A Method to Increase Buprenorphine Treatment Capacity and Effectiveness

    SBC: CBT4CBT, LLC            Topic: R42

    The goal of this fast track STTR proposal is to expand buprenorphine maintenance therapy for opioiddependent patientsOvermillion people in the US are addicted to opiatesProviding effective agonist therapymethadone or buprenorphinecoupled with behavioral counseling greatly improves outcomesreduces morbidityand reduces societal costsMethadone maintenance treatment has been limited due to complex sta ...

    STTR Phase II 2018 Department of Health and Human Services
  5. Development of an Oral Acidic Mammalian Chitinase Inhibitor to Treat Asthma

    SBC: ONCOARENDI THERAPEUTICS LLC            Topic: NHLBI

    Approximatelymillion Americans suffer from asthmawhich leads to aboutdeaths per yearand is responsible for estimated annual total direct and indirect costs of $billionDespite the existing treatments for asthmapredominantly combinations of inhaledagonists and corticosteroidsCSsthere remains a significant unmet medical need for new therapies which address two key issuesapproximatelyof patients are i ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. An integrated mobile and web-based application for problem cannabis use

    SBC: Checkup and Choices LLC            Topic: NIDA

    The objective of this research project is to develop an integrated set of digital tools that will deliver a brief motivational interventionBMIfor young adult marijuana users across a variety of platformsWe havein four randomized clinical trialsdemonstrated the effectiveness of similar tech based interventions for problem drinkingThese interventions have been integrated into one comprehensive progr ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. An antigen-detection assay to diagnose Babesia microti infection

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    Project Summary Human babesiosis is a malaria like multisystem disease caused primarily by Babesia microtian emerging apicomplexan parasite that infects and develops within human erythrocytesThe parasite is transmitted to humans by the tick vector Ixodes scapularis and can also be introduced through blood transfusionInfection can cause flu like symptomsand severe infection can be fatalin particula ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. A high throughput next generation sequencing (NGS) pipeline to generate high quality recombinant therapeutic antibodies

    SBC: Specifica Inc.            Topic: 100

    Abstract Therapeutic antibodies are used to treat many different diseasesincluding cancerauto immunityinfection and atherosclerosisThey are the fastest growing class of pharmaceuticalswith annual revenues of$B inOne of the most important methods to select therapeutic antibodies is by selection from vast antibody librariesHowevergood libraries are extremely challenging to produceand commercially av ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Development of a hybrid transcatheter mitral valve replacement and repair device

    SBC: Dura LLC            Topic: NHLBI

    PROJECT SUMMARYMitral regurgitationMRis the most prevalent valvular heart disease in the U Saffecting approximatelyof the populationThere aremillion patients in the US with moderate to severe MR requiring treatmentHoweveronly approximatelypatients in the U Sundergo surgery for MR each year due to concerns about procedural complexity and patient safetyThere is great enthusiasm among the heart valve ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Bioengineered skin microbiota for cutaneous mitigation of Netherton Syndrome

    SBC: Azitra Inc.            Topic: NIAMS

    PROJECT SUMMARY Current treatment options for many skin diseases especially rare diseases fail to address the underlying causative pathophysiologiesIn the case of genetic mutations that cause loss of function mutationssupplementing the missing protein is a viable approach to treatmentHoweverdelivery of functional protein to the target keratinocytes presents a significant challengemoreoverthe cost ...

    SBIR Phase I 2018 Department of Health and Human Services

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