Award Data

DESCRIPTION provided by applicant Alcohol misuse is a significant public health problem not only in the US but around the world Just in the US alcohol misuse is estimated to be the second cause of preventable death at a cost of more than $ billion in a single year Further it is also estimated that it reduces the lives of those who died by years Screening and brief interventions have ...

DESCRIPTION provided by applicant Age related memory loss is a growing public health issue which will be magnified in the coming decades by increasing life expectancies and the aging baby boomer population Age is the most important risk factor for developing dementia of the population between and has some form of dementia between and and of those or older The the ...

DESCRIPTION provided by applicant Hepatitis infection is a widespread and persistent crisis both in the U S and worldwide Chronic infection with the hepatitis B virus HBV is a major cause of end stage liver disease with staggering long term healthcare costs Thus HBV research and innovation have been deemed national priorities in the U S as evidenced by calls to action by the Institute ...

DESCRIPTION provided by applicant The hypothesis for this project is that a novel compound Peptide Inhibitor of complement C PIC will inhibit antibody initiated complement mediated cell destruction in a xenotransfusion animal model Complement is the most potent inflammatory cascade in humans and is initiated by antibodies driving classical pathway activation and host cell destruction in ...

DESCRIPTION provided by applicant Galectin a beta galactoside binding lectin is involved in the progression of many cancers In our recent publication in PNAS PMC we have shown that in prostate cancer galectin promotes tumor angiogenesis tumor endothelial cell adhesion and metastasis and also evades immune surveillance through killing of infiltrating T cells To block galecti ...

DESCRIPTION provided by applicant Systemic sclerosis scleroderma SSc is a chronic autoimmune disease characterized by proliferative vascular lesions with resultant fibrosis of skin and other multiple organs including the gastrointestinal GI tract In the United States the prevalence of SSc is about per million in adults Up to of SSc patients are reported to have upper and lower ...

DESCRIPTIONprovided by applicantThe goal of this SBIR project is to develop a minimally intrusivehighly sensitive risk stratification tool to determine the need for invasive pancreatic cancerPCscreeningPC is theth leading cause of cancer deaths in the USWhile early stage disease is generally curablethe vast majority of patients are diagnosed in advancedunresectable stages due in large part to the ...

DESCRIPTION provided by applicant Low vision rehabilitation is the only proven way to restore functional vision and maintain a high quality of life in patients with permanent vision impairment Low vision aids are devices that manipulate visual information for example magnify images to compensate for impaired vision The patientandapos s willingness to accept a low vision aid ability to ada ...

DESCRIPTION provided by applicant Nine cell therapy products having a $ $ million market size have been approved for use in the United States or EU With the anticipated approval of additional products the cell therapy market is expected to grow at an annualized rate of greater than through the remainder of the decade Creation of cell therapy products employ four unit operatio ...

DESCRIPTION provided by applicant Pattern recognition PR myoelectric control systems can dramatically improve an amputee patientandapos s control of a powered prosthesis but they still require that the user perform sequential movements to achieve a task Coapt LLC is an early stage company that has initiated a controlled commercial release of PR myoelectric control for the benefit of upper ...