Award Data

DESCRIPTION (provided by applicant): The objective of this SBIR program is the modification of a polymeric trileaflet heart valve to a valve prosthesis that can be delivered percutaneously as a transcatheter aortic valve replacement. Key innovations include improved durability and hemodynamic properties, lower manufacturing costs, and simplified delivery over existing transcatheter bioprosthetic v ...

DESCRIPTION (provided by applicant): The overall objective of this proposed program is the commercialization of the Pediatric Impella system, a minimally invasive ventricular assist device (VAD) for treatment of acute heart failure in pediatric patients. The device will be a less traumatic alternative to extracorporeal membrane oxygenation (ECMO), the current standard of care for these patients. T ...

DESCRIPTION (provided by applicant): Methadone is an important long-term maintenance therapy for drug addiction and currently is frequently used for analgesia. However, methadone prolongs the QT interval on the electrocardiogram and this increases risk for life threatening arrhythmias and has led to the FDA's placing a black box warning on methadone's label. Initial studies in our laboratory hav ...

DESCRIPTION (provided by applicant): Detection of exposure to environmental agents by measurement of internal dose of such agents or their metabolites, chemical or biological, requires rapid assessment and identification of exposure to both known and unknown threats. Fast detection and identification of exposure to such threats can provide prompt warning of the extent and severity of the exposure ...

DESCRIPTION (provided by applicant): Scintillation crystals coupled to photomultiplier tubes or silicon diodes are the most common detectors for X-ray/3-ray detection. Imaging modalities such as positron emission tomography (PET), single photon emission computed tomography (SPECT), digital radiography (including digital mammography) and X-ray CT are critically important for cancer diagnosis, stagi ...

DESCRIPTION (provided by applicant): Among the various functional imaging techniques, SPECT maintains an important and growing role in the study of disease models in small animals as well as in patient care. Many SPECT-labeled imaging probes that have highly specific distributions with very little background are being used to measure a wide range of biological parameters of importance in small ani ...

DESCRIPTION (provided by applicant): Simultaneous PET-MR Small Animal Imaging Principal Investigator: Dr. Gerald Entine, Ph.D. Abstract: The ideal biological imaging system would provide non-invasive, high-resolution, high-sensitivity, three-dimensional (3D) images of living systems. Positron Emission Tomography (PET) offers high sensitivity to a range of biological processes through the ...

Mutation of genetic DNA is a major factor causing cancer. Locating these changes in the DNA sequence of single molecules is difficult because they cannot be assayed by conventional sequencing techniques. This project will demonstrate sequencing capabilities for single stranded DNA and RNA immobilized on a novel substrate, and demonstrate a novel method for increasing throughput. Sensitivity to mid ...

DESCRIPTION (provided by applicant): Surgeons face several challenges associated with intra- and post-operative blood loss. A limited supply of blood available for transfusion and injurious results involving transfusion reactions and disease transmission using allogenic blood, make blood component separation, embolus removal, and reinfusion of the patient's own shed blood an attractive option. In ...

Recognizing the ability of synchrotron sources to deliver increasingly higher photon fluxes and the correspondingly rising, demanding needs of time-resolved applications, along with the limitations of current imaging modalities, the need for the development of an innovative detector technology for photon counting in X-ray imaging has become apparent to researchers and equipment manufacturers alike ...