Award Data

DESCRIPTION (provided by applicant): The main objective of this project is to develop a new therapeutic to improve the outcome for patients with intermediate-risk prostate cancer. The indication is a first-line adjuvant to be combined with radiation therapy for prostate cancer. The desired outcomes are improved local control rate, decreased recurrence and improved disease-free survival. This grant ...

Gamma radiation detection has traditionally required single crystal materials that are difficult to produce consistently on an industrial scale. Agiltron has developed a new class of scintillator materials based on composites containing nanoparticles. These so-called nanocomposites exhibit radiation detection characteristics superior to currently available single crystal scintillators. In Phase I ...

DESCRIPTION (provided by applicant): New, Solid-State Photosensor for PET Positron Emission Tomography (PET) is a functional imaging technique with potential to quantify the rates of biological processes in vivo. The availability of short lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine, allows virtually any compound of biological interest to be labeled in trace ...

DESCRIPTION (provided by applicant): High Resolution Detectors for Single Photon Cardiac Imaging Single photon emission computed tomography (SPECT) is a powerful, noninvasive medical imaging modality that mathematically reconstructs the three dimensional distribution of a radionuclide throughout the body of a human patient or a research animal. Typically, the collected data are displayed and evalu ...

DESCRIPTION (provided by applicant): Neutron techniques complement X-ray diffraction techniques in their ability to precisely locate hydrogen and light atoms in various materials. This information is critical for determining the structure and function of proteins and for the discovery of biological processes taking place on a sub-molecular level, the knowledge of which is necessary in the fields o ...

DESCRIPTION (provided by applicant): Recent extraordinary developments in synchrotron radiation sources have enabled the growth of powerful research techniques such as time-resolved X-ray diffraction studies, essential for understanding dynamic biological phenomena and recovering phase information in X-ray crystallography. To make the most effective use of these advanced synchrotron sources for im ...

DESCRIPTION (provided by applicant): The long-term objective of this project is to develop a tumor-targeted TCR-IL2 fusion protein, ALT-801, as an immunotherapeutic for treatment of p53-positive cancers. The TCR portion of this fusion protein is specific for a peptide derived from the tumor-associated protein p53 presented in the context of HLA- A2.1. This high-affinity TCR is designed to guide th ...

DESCRIPTION (provided by applicant): A key rationale of this project is the growing need for an improved low-cost, high sensitivity multigene mutation profiling method for tumors. An important example is the recent recommendation of the National Comprehensive Cancer Network (NCCN) to screen all patients diagnosed with metastatic colorectal cancer for KRAS mutations in the primary tumor or a site o ...

DESCRIPTION (provided by applicant): We propose to develop a rapid, low cost, threshold assay for the detection of HIV infection of HIV vaccination trial participants. The assay we propose to develop will use our proprietary helicase dependent amplification (HDA) platform as well as a low cost device specifically designed to perform molecular tests without contaminating the laboratory with amplifi ...

DESCRIPTION (provided by applicant): Approximately 1 out of every 5 Americans is infected with herpes simplex virus type 2 (HSV-2). Localized genital infection by HSV-2 results in painful recurring genital lesions while disseminated infection can involve multiple visceral organs and lethal encephalitis. Using Phase 1 funding we have developed a new heterologous immunization protocol composed of a ...