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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

Displaying 1 - 10 of 5999 results
  1. Randomized Prospective Phase II Clinical Trial of NVX in Association with Chemoradiation of Glioblastoma

    SBC: NUVOX PHARMA, L.L.C.            Topic: 102

    Glioblastoma multiforme GBM is a malignant primary brain tumor affecting about new cases per year in the U S Average survival is only about months Radiation RT is most commonly administered as fractions of Gray each over weeks with concomitant temozolomide TMZ GBM tumors are hypoxic The primary mechanism of RT is creation of singlet oxygen hypoxia within GBM adversel ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Brain-enriched microRNAs detectable in plasma as biomarkers of Alzheimer's disease

    SBC: DIAMIR, LLC            Topic: NIA

    SUMMARY Aboutof Americans agehave Mild Cognitive ImpairmentMCIof whichprogress to dementia annuallyA growing number of companies are developing new therapeutics aiming to intervene early in the development of Alzheimer s diseasethe most common form of dementiaand there is a great need for accurateminimally invasive diagnostics for primary screening of individuals with earlyincluding presymptomatic ...

    SBIR Phase II 2017 Department of Health and Human Services
  3. Clinical Evaluation of a Resorbable Vena Cava Filter

    SBC: Adient Medical Inc.            Topic: NHLBI

    PROJECT SUMMARYClinical Evaluation of a Resorbable Inferior Vena Cava FilterPulmonary embolismPEis therd leading cause of deathclaiming the lives of at leastAmericans annuallymore than breast cancerAIDSand vehicle fatalities combinedMetallic Inferior Vena CavaIVCfilters have been proven effective in reducing PE to aboutin at risk populationshoweverthey come with a heavy post deployment pricenamely ...

    SBIR Phase II 2017 Department of Health and Human Services
  4. Correlating TCR diversity to immune reconstitution after cord blood transplant

    SBC: ADAPTIVE BIOTECHNOLOGIES CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Unicondylar Resurfacing in an Ovine Osteoarthritis Disease Model

    SBC: Cytex Therapeutics, Inc.            Topic: NIAMS

    AbstractThe treatment of large cartilage lesions is a difficult clinical problem for which there are few good solutionsLeft untreatedthese lesions tend to degenerate to chronic pain and osteoarthritisOAultimately requiring a total joint replacementFor patients suffering from knee OAandin particularunicompartmental OAunicondylar knee arthroplastyUKAis an available first line treatment option that p ...

    STTR Phase II 2017 Department of Health and Human Services
  6. An Integrated Microarray Printing and Detection System

    SBC: BIOSENSING INSTRUMENT INC            Topic: 400

    DESCRIPTIONprovided by applicantMicroarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugsTypicallyprotein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another deviceDuring each testing cyclethe entire microarray becomes exposed to the pro ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. Service and Software Solution for the Rigorous Design of Animal Studies

    SBC: SERALOGIX, LLC            Topic: NIDA

    The primary goal of this fast track project is to commercialize a cloud based software suite complemented with on call expert services to guide life science researchersthat may have minimal statistical and experimental designEDknowledgeto rigorously planoptimizejustifymanageand report results for complex animal studiesInadequately planned experimentse glack of randomization blinding and diversityl ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. An Ultra filtrate perfusion bio artificial pancreas for high-density islet replacement without immunosuppression

    SBC: Cell-Safe Life Sciences LLC            Topic: NIDDK

    DESCRIPTIONprovided by applicantThe Cell SafeTM is a fundamentally new approach in replacement of dysfunctional insulin producing cells in patients with diabetesby transplantation of new islets in a three dimensional scaffold embedded in a highly compatible bioengineered perfusion system that continuously supplies tissue fluidblood ultrafiltrateso that the cells ae protected from immune rejection ...

    STTR Phase II 2017 Department of Health and Human Services
  9. STTR Phase I: Autonomous Landing of sUAS onto Moving Platforms

    SBC: Planck Aerosystems, Inc.            Topic: EW

    The broader impact/commercial potential of this project is the expansion of autonomous unmanned aerial systems (UAS, or drones) to new maritime operational environments and commercial markets. The proposed technology will enable small UAS to operate from vessels moving at sea, without the need for a dedicated pilot or installed hardware, even while far from shore and beyond the reach of establishe ...

    STTR Phase I 2017 National Science Foundation
  10. STTR Phase I: A Low Cost Robotics kit for Elementary Education

    SBC: BirdBrain Technologies LLC            Topic: EA

    This project intends to design and develop a programmable electronics and robotics kit that catalyzes the learning of computational thinking, engineering design, and making at a price point that will be affordable for large numbers of elementary school classrooms throughout the nation. Such an educational robotics kit benefits society by positively influencing science, technology, engineering, and ...

    STTR Phase I 2017 National Science Foundation

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