Award Data

IST-Rolla developed two nonlinear filters for spacecraft orbit determination during the Phase I contract. The theta-D filter and the cost based filter, CBF, were developed and used in various orbit determination scenarios. The scenarios were application to low Earth orbit, range only, and range and range rate estimation. The modified state observer was also developed to estimate uncertainty in t ...

Detection of bioaerosols is a cornerstone in the protection of our nation from bioterrorist events. Rapid bioaerosol detection systems have advanced dramatically in recent years, but the lack of integratable automated sample preparation for these systems remains a major deficiency. Three significant issues associated with current sample preparation components in these systems are (a) a lack of an ...

DESCRIPTION (provided by applicant): Organ transplantation is one of the great success stories of modern medicine. However, the supply of suitable organs lags far behind the need and many patients die while waitlisted for organs. While there have been manyrecent strides in organ procurement, preservation and follow-up immune suppression, prevention of ischemia-reperfusion injury (IRI) remains prob ...

This Small Business Innovation Research (SBIR) by Mo-Sci Corporation in collaboration with the Indiana University School of Dentistry (IU) and the Missouri University of Science & Technology (Missouri S & T) proposes to use bioactive glass bone scaffolds for bone repair. The objective is to develop a completely artificial bone substitute material that mimics human bone and can replace long bones, ...

DESCRIPTION (provided by applicant): Nitric oxide (NO) has been shown to have powerful, broad-spectrum antimicrobial activity as well as benefits in wound healing when properly administered [1-3]. The combination of these two attributes makes development of a non-systemic NO delivery approach valuable for hospital and outpatient applications to prevent infection and accelerate wound healing. Such ...

HyBeacons Probe Assays for the Detection of Ticks and Tick-Borne Pathogens Patrick Williams, Ph.D., Evogen Inc., 8301 State Line Road, Kansas City, MO 64114 The proposed development will evaluate the use of Evogen"s HyBeacons probes for rapid, multiplexed vector and pathogen detection using Evogen ONE sample processing, multiplex amplification detection, and high temperature melt curve analysis. ...

DESCRIPTION (provided by applicant): Cells secrete hormones and neurotransmitter via exocytosis. Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance. The overall goal of this SBIRproject is to use microfabrication technology to develop a robust and easy-to-use prototype device that can assay release of transmitter from in ...

DESCRIPTION (provided by applicant): Atrial fibrillation (AF) is the most prevalent clinical arrhythmia in clinical practice and a major contributor to morbidity and mortality. A recent study estimated that the number of Americans afflicted by AF will increase from the current range of 2.2 to 5.6 million to more than 12 million by 2050. This increase will be driven significantly by demographics, s ...

A Fast Impulse Solid Fuel Miniature Thruster system will be developed for a specific application beneficial to the US Army. The selection of right nanoenergetic material will be done from various fuel-oxidizer systems to obtain thrust and specific impulse as required by the application. Fine-tuning the selected material will be done to match the established scaling law. A suitable design and manuf ...

Refrigeration and air conditioning in buildings, industry, and transportation account for approximately 10 quads of U.S. primary energy consumption. Motors power the equipment and control the environment in advanced cooling applications and thus their energy consumption represents a significant part of their operating and life cycle costs.Fan motors for heating, cooling and ventilation run the mos ...