Award Data

DESCRIPTION (provided by applicant): Founded in 1999, Adenosine Therapeutics LLC (ATL) is a drug discovery and development company that has developed a family of potent and selective adenosine A2A receptor agonists. With the help of STTR funding, ATL has developed a lead adenosine A2A receptor agonist, ATL-146e, that is currently in late Phase II of clinical development for use as a coronary vaso ...

DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) accounts for approximately 40% of the cases of renal failure requiring dialysis or transplantation. Moreover, diabetic nephropathy is associated with markedly higher morbidity and mortality rates. It is important to develop novel interventions to prevent complications of diabetes. Inflammation in the genesis of diabetes, as well as its ...

DESCRIPTION (provided by applicant): Diabetic nephropathy (DN) accounts for approximately 40% of the cases of renal failure requiring dialysis or transplantation. Moreover, diabetic nephropathy is associated with markedly higher morbidity and mortality rates. It is important to develop novel interventions to prevent complications of diabetes. Inflammation in the genesis of diabetes, as well as its ...

DESCRIPTION (PROVIDED BY APPLICANT): Selective antagonists of A2A adenosine receptors have proven to be effective for the treatment of Parkinson's disease (PD) both in animal models and in a human trial. However, the initial clinical trial was stopped in phase 3 due to detection of animal toxicity of KW6002. Other investigational compounds lack sufficient potency, selectivity or bioavailability to ...

DESCRIPTION (PROVIDED BY APPLICANT): Selective antagonists of A2A adenosine receptors have proven to be effective for the treatment of Parkinson's disease (PD) both in animal models and in a human trial. However, the initial clinical trial was stopped in phase 3 due to detection of animal toxicity of KW6002. Other investigational compounds lack sufficient potency, selectivity or bioavailability to ...

StarVision Technologies proposes to conduct an experimental feasibility assessment of an innovative and robust Autonomous Aerial Refueling System (AARS). The system has been developed specifically for powered munitions and will provide significant battlefield enhancements by allowing persistent and sustained air operations. The AARS proposed is the result of several years of studies and feasibili ...

Impact Technologies proposes to develop a Matlab/SimulinkT based Probabilistic Modeling and Analysis Toolbox (P-MAT) application that provides an intuitive and information-rich modeling environment for probabilistic reliability analysis with a powerful toolset consisting of Bayesian Update, Monte Carlo, 3rd party software integration and other modules. At the conclusion of Phase I, the USAF will ...

DESCRIPTION (provided by applicant): Density-Functional Theory (DFT) is highly desirable for modeling biomolecules due to its accuracy. While DFT calculations of the energy are now common for large molecules, the use of DFT geometry optimizers is still confined to relatively small molecules containing no more than thirty atoms. The key limitation is that the number of steps required to reach the o ...

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is a promising biological marker for psychological research. The primary goal of this project is to make the LFCR methodology more accessible to researchers by providing a both a product and extensive support services. In Phase I, a prototype system was built and used to collect simultaneous physiological and cognitive da ...

BioRobots proposes the development of a Morphing Micro Air-Land Vehicle (MMALV), capable of transforming from aerial to terrestrial locomotion, to maximize situational awareness for U.S. warfighters. Terrestrial locomotion is based upon the Mini-Whegs platform, recognized as one of the most agile micro-robots today. Aerial locomotion is based upon the University of Florida Micro Air Vehicle (UF- ...