Award Data

Recent foodborne illness outbreaks traced to contaminated field harvesting equipment have highlighted the need for incorporating improved sanitization practices at the time of harvest. Field- harvested specialty crops represent 50% of the top ten foods linked to major recalls and outbreaks over the past five years. Proper sanitization of outdoor harvest equipment is made complicated by operational ...

PROJECT SUMMARY/ABSTRACT The MYC family proteins are comprised of three paralogs termed c-myc, N-myc, and L-myc. The MYC proteins play a fundamental role in cell proliferation and oncogenesis by regulating cellular processes such as gene transcription, protein translation, cell cycle progression, and cell death. While N-myc and L-myc drive oncogenesis in a small number of cancer types, the require ...

ABSTRACT Pulmonary arterial hypertension (PAH) is a fatal disease (without curative therapies) that is critically influenced by dysregulated inflammatory pathways. This A1 R42 Fast Track STTR application focuses on eNAMPT (extra- cellular nicotinamide phosphoribosyltransferase) as a novel, highly attractive PAH target. Aqualung Therapeutics has developed a humanized eNAMPT-neutralizing mAb, ALT-10 ...

The objective of this VAS rangefinder Phase I SBIR effort is to complete key enabling trade studies which will inform the development of the range finder through a Phase II effort. The resulting VAS rangefinder will be a low-cost, easy-to-use device that is capable of operating 24/7 in urban or near-urban environments with ambient light sources.

1 Abstract2 Bold Type is developing the “SenseWand”, a wireless pelvic floor diagnostic system (device and app)3 to evaluate pelvic floor muscle health using electrical impedance myography (EIM). PFDs are complex4 conditions (e.g. pelvic organ prolapse, stress urinary incontinence, high tone pelvic floor dysfunction) that impact5 millions of women worldwide. It is estimated that PFDs will affe ...

Alzheimer's disease (AD) is a devastating and progressive disease without a cure. Neuroinflammation is now recognized as a key early event in the development of AD. Aberrant neuroinflammatory response activates immune cells that can increase oxidative stress, and oxidative stress can directly damage neurons and axons, cause demyelination, and break down the blood-brain barrier (BBB). Thus, damagin ...

We are developing vaccine antigens for SARS-CoV-2 that focus the antibody response onto neutralizing epitopes in the receptor binding domain (RBD) of the viral Spike (S) protein. Booster antigens derived from variants of SARS-CoV-2 would especially benefit from being limited to the RBD, due to the preponderance of conserved but non-neutralizing epitopes in the full-length S protein. However, RBD-o ...

Requirement of a portable device that can translate spoken conversations between Taiwan Hokkien and English. No commercially available product exists that can provide this capability, which is 100% disconnected from the cloud. The first challenge is to ensure the device's portability and accuracy of the translation without an Internet connection. The second challenge is the lack of existing data t ...

For this Phase I SBIR project, Vcom3D will research and develop a modular, proof-of-concept Mixed Reality (MR) Extreme Cold Simulation Trainer for Medic Education (ECSTREME). The system will build on available Modular Healthcare Simulation and Education System (MoHSES) open standards, interoperable modules, and open-source resources. We will demonstrate and evaluate a proof-of-concept ECSTREME sys ...

ArchieMD's proposed haptic VR simulations for cold weather injury assessment, management, and treatment combine the most important aspects of various skills training pedagogies into a single immersive training system. This system will incorporate and overlay theoretical knowledge in a practical context to supplement traditional educational models. The military has more recently acknowledged the ne ...