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To address DARPAs need for a more efficient group-to-group communication technology for low size, weight, and power (SWaP) sensor ensembles or swarms, Physical Optics Corporation (POC) proposes to develop a new Inter-ensemble Coherent Distributed Communication (ICDC) technology based on a coherent distributed beamforming from a map-based, deterministic signal transmission and reception. Specifical ...

Vadum will develop and simulate a new communications protocol for Distributed Coherent Beamforming (DCB) that will implement bi-directional distributed TX and RX beamforming algorithms between two or more groups of wireless nodes with no prior spatial awareness (i.e. GPS not required). The Vadum approach uses an innovative Master-Slave architecture to implicitly achieve frequency and timing synchr ...

Wireless communications have become ubiquitous for the last two decades, especially with the advent of affordable cellular communications. While cellular systems utilize base stations to ensure connectedness of the network, many situations can arise wherein wireless nodes form a disconnected network. Examples include communication in infrastructure-less regions or in emergency events, with a sudde ...

Tactical networks need to support high data rate communications, situational awareness and connectivity over long distances possibly between disaggregated groups of communications nodes, e.g., in airborne networks. Therefore, it is essential to design a coherent communication solution to achieve high power gain and improve signal quality at receivers. Since communication nodes are not physically c ...

Therapeutic drug monitoring (TDM) is becoming prevalent in the hospital, especially in the treatment of critically ill patients where pharmacokinetic and pharmacodynamic profiles are compromised due to severe illness. The ability for doctors to evaluate how much active drug is being delivered in real time can enable adaptive treatment options that will result in better patient outcome while reduci ...

Optimization of the prescription of antimicrobials is required to improve clinical outcome from infections and to reduce the development of antimicrobial resistance. Maximizing the effectiveness whilst simultaneously minimizing the toxicity of antimicrobial agents is the most important step in any effective treatment regimen, however, escalating antibiotic resistance, lack of novel antibiotics and ...

In this SBIR proposal, ProbiusDx aims to develop a non-invasive point of care diagnostic technology for detecting and monitoring blood concentrations of antimicrobial drugs. The ability to measure drug concentrations in a patients blood provides valuable information for individualized optimal dosing, maximal efficacy and reduced potential for undesirable side effects. Our ground-breaking work at ...

We propose to take our binaural OtoStat-HCP hearing-test system, which was designed for advanced hearing-conservation programs (HCPs), and ruggedize it for use in theater. OtoStat-HCP includes pure-tone audiometry, otoacoustic emission (OAE), and wideband immittance tests. Commercial-off-the-shelf OAE systems are unsuitable for HCPs, so we will: 1) implement next-generation OAE tests to enable qua ...

Intraocular surgery is usually performed under stereoscopic guidance using a surgical microscope. The surgeon is usually able to see intraocular structures through a clear cornea. However, when the optical clarity of the cornea is severely compromised, visualization of the retina and other intraocular structures is very difficult or impossible. Poor visualization of intraocular structures during s ...

Vitrification, cryopreserved storage in a “glassy” rather than crystalline phase, is an important enabling approach for tissue banking and regenerative medicine, offering the ability to store and transport cells, tissues and organs for a variety of biomedical uses without the risks of damaging ice formation. Unfortunately, practical application of vitrification has been limited to reproductive ...