Award Data

In this Phase II SBIR effort we will dramatically reduce the size, weight, and power requirements of a passive millimeter wave imaging system based on optical upconversion. To this end, we will integrate custom silicon-germanium low noise amplifiers that have been designed to efficiently couple with our high performance lithium niobate upconversion modules. In Phase I we analyzed the design requ ...

One major cause of the widespread of drug-resistant and virulent bacteria pathogen is the horizontal gene transfer of resistance and virulence genes in the form of plasmids. As proof-of concept for this Phase I effort, Agave BioSystems proposes to develop combinatorial therapeutics by inhibiting conserved genes involved in multiple steps of plasmid transfer and replication using peptide nucleic a ...

This proposed effort focuses on the development and demonstration of an extended short wavelength infrared (eSWIR) micro-camera that is capable of identifying targets at ranges of 100 to 1000 meters with a 40 degree field of view, through a collaborative effort between the proposing small business Episensors, Inc., BAE Systems and Digital Design Corporation. Innovative materials and device proces ...

In this program, we will develop and prototype a new Super-Resolution Magnetic Field Microscopy (SRMFM) system that employs nitrogen-vacancy (NV) centers in diamond nanostructures to image magnetic fields with a sensitivity below 100nT/ & #8730;Hz and a spatial resolution better than 20 nm. The system consists of two primary components: (1) hardware and software for NV electron spin-based imaging ...

NOHMs Technologies proposes to demonstrate the feasibility of developing a novel Lithium-Sulfur chemistry for electrical energy storage that provides high charge and discharge rates, high cycle life, and high energy density. The proposed technology is based on innovative sulfur-infused carbon composite cathode materials (developed at Cornell University), which overcome the poor cycle life problem ...

There is at present a lack of portable, practical and non-invasive sensing platforms to: a. understand, detect and present neural events triggered by narratives; b. to derive cognitive interpretations of a story and link them to semantic interpretations, the story"s function and/or the storyteller"s intent. Based on the Phase I design of a system, termed"Cognitive Capture", to enable the unobtrusi ...

AuraSense Therapeutics is developing oligonucleotide-modified gold nanoparticles called spherical nucleic acid (SNA) constructs, which are a powerful new way of regulating cellular gene expression. AuraSense Therapeutics will use SNAs as genetically programmable antimicrobial agents in a manner to provide a rapid and effective way to develop next generation antibiotics. The outcome of this work wi ...

Agave BioSystems proposed to develop a system of Rapidly Adaptable Nanotherapeutics (RANT) by combining advanced bioformatics, with DNA-based nanoparticles, peptide nucleic acid (PNA) antisense oligonucleotides, and cell permeating peptides (CPPs). Advanced bioinformatics computing will allow for the identification of essential and drug resistance genes within the target pathogens. These genes w ...

This firm does not wish to sumbit public abstract for the proposal High engine overall pressure ratios (OPR) enable more efficient operation for gas turbine engines, but also require higher turbine inlet temperatures. The temperature capabilities of hot section hardware have been improved through alloy development, manufacturing processes, air cooling, and thermal barrier coatings (TBC). However ...

This project team is developing a prototype of a delivery platform to host four web-based interactive games to help students overcome scientific misconceptions in middle-grade science. At present, the games are compatible with the Nintendo DSi platform, and include classroom activities that include PowerPoint and print materials. This project team will convert and enhance the games and materials f ...