Award Data

In vitro expansion of hematopoietic cells finds many applications in the clinic. This technique hasexpanding CD34+ cells for transplantation/re infusion, although most of the technology has consistedcultures in which there is variable CFUGM expansions and failure to maintain LTC IC (long term cultuThe Investigators have found that perfusion cultures of bone marrow mononuclear cells result in expaC ...

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XRD Inc. will deliver a feasibility study and work plan to produce engines operating on heavy fuel that meets the objectives of Program Solicitation entitled “Small Engines designed for High Efficiency, High Power Density and Quiet Operations”. The goal is to have power density greater than 1 hp per pound and greater than 25% thermal efficiency while operating on available heavy fuels. This n ...

DESCRIPTION (provided by applicant): There is a growing body of evidence that implicates the protein kinase Pim-1 as a major driver of prostate cancer progression, and perhaps response to chemotherapy. Pim-1 is overexpressed in early prostate intraepithelial neoplasia and metastatic prostate cancer, and its levels predict response to therapy. Pim-1-overexpressing mouse prostate stem cells demonstr ...

As an alternative to holographic laser radar, AMPS will develop a 3-D imaging concept that collects far-field intensity speckle patterns. This kind of measurement greatly relaxes the tolerances on vibration and coherence length. However, phase retrieval will be required to retrieve a 3-D image. Phase retrieval algorithms typically utilize some type of prior knowledge about the object. In industria ...

Alkali Metal Thermal to Electric Converters (AMTEC) convert heat to electricity at high efficiency without moving parts at temperatures compatible with current solar receiver technology. A Phase I program is proposed which will deliver an integrated, high-temperature thermal storage/high-efficiency AMTEC cell system concepts and a small-scale thermal energy storage (TES) test article for material ...

This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer Phase I project will address the problem of a multifunctional wide band-gap aluminum gallium nitride single crystal substrate that will enable low-defect, high-performance epitaxial growth. Since much of the energy consumed in the U.S. used for traditional ligh ...

This Small Business Innovative Research Phase I project is to develop a commercial growth process for single crystals of KBe2BO3F2 (KBBF) using hydrothermal techniques. KBBF shows exceptional promise as a deep UV non-linear optical material (NLO). NLOs are vital for the development of solid-state lasers with wavelengths below 200 nm for use in photolithography, micromachining and spectroscopy. The ...

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