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We propose to develop a prototype for direct electrochemical DNA sensor, using oligonucleotide-doped conductive polymer electrode. Phase I is dedicated to development and characterization of smallpox-specific DNA sensor. Stability, sensitivity,selectivity, reproducibility of DNA detection by the prototype electrode will be characterized with regards to both oligonucleotide- and double stranded DNA ...

Large X-ray generators using gas fill loads are a key element in the DTRA simulator program. Consistent relative timing between the injection of the gas shell and the generator current pulse is crucial to producing consistent, high-yield x-ray pulses.To that end HY-Tech proposes replacing existing high voltage trigger pin technology, with a sensitive, all fiber-optic heterodyne interferometer ba ...

OBJECTIVE: Develop a Forensic DNA Analysis Kit for Genetic Intelligence that can be used on unknown human DNA samples collected from the battlefield to provide information about the individual who deposited the sample, such as potential ethnicity, height, eye color, hair color, age, sex, and/or facial features. The kit should leverage Short Tandem Repeats (STR), Single Nucleotide Polymorphisms (S ...

Surface detection of specific radioisotopes of the noble gases xenon and argon are essential for detection and discrimination of underground nuclear explosions. We propose a unique combination of numerical modeling and stable isotope release experiments to enhance the predictability of subsurface transport of the noble gases of interest. Our proposed research will identify and quantify the physi ...

Reliable automated pattern recognition in the current system is limited by excessive noise and clutter combined with insufficient and/or ambiguous features. Our team consisting of AcornSI and Leidos thus propose a multi-step approach based on the combined effects of improved detection, feature extraction, phase identification, and global association. A key innovation here is creating a new classif ...

The Radionuclide Aerosol Sampler and Analyzer (RASA) is a completely automated monitoring system that detects airborne radioactive particles and is one of the detection systems used in the U.S. and global International Monitoring System (IMS) of the Comprehensive Nuclear Test Ban Treaty Organization (CTBTO) to detect nuclear detonations. Mainstream proposes develop a high-efficiency cyclone separa ...