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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A New Approach to Vision Therapy Based on Naturalistic 3-D Computer Gaming

    SBC: BARRON ASSOCIATES, INC.            Topic: NEI

    DESCRIPTION (provided by applicant): Convergence disorders and refractive amblyopia are among the most common and treatable vision problems seen in general optometric clinical practice. Oce- and home-based vision therapy (OBVT and HBVT, respectively) are standard treatments for such disorders. Recent advances in computerized video therapies that emulate vision therapy exercises performed in the op ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Phytostabilization and Retirement of Mercury from Wet Ecosystems

    SBC: Edenspace Systems Corporation            Topic: NIEHS

    DESCRIPTION (provided by applicant): Because environmental mercury poses significant challenges to global public health, reducing mercury levels in air, soil, and water is an international priority. Widespread distribution of mercury (Hg) by the atmosphere makes current methods of addressing Hg contamination, such as excavation and replacement of soil, too expensive to be practical given the typic ...

    SBIR Phase I 2010 Department of Health and Human Services
  3. MULTIFUNCTIONAL NANODEVICE FOR TARGETED CANCER MR IMAGING AND

    SBC: Luna Innovations Incorporated            Topic: NCI

    Multifunctional theranostic nanodevices carrying therapeutic payloads, diagnostic agents, and targeted and controlled drug release functions can simultaneously and effectively diagnose and treat cancers. The targeted delivery of chemotherapeutics to tumors can significantly increase the efficacy of drugs while minimizing the severe side effects associated with the drug itself. The integration of ...

    SBIR Phase I 2010 Department of Health and Human Services
  4. Novel Protein-Free Material for Minimally Compressive Surgical Hemostasis

    SBC: Luna Innovations Incorporated            Topic: NHLBI

    DESCRIPTION (provided by applicant): Novel protein-free material for minimally compressive surgical hemostasis (Patrick S. Cottler, P.I.) Excessive blood loss is a risk in any surgery, and hemostasis is problematic in minimally invasive and spinal procedures where direct access to the hemorrhage is difficult and external compression is impractical. Although blood transfusion is an accepted and l ...

    SBIR Phase I 2010 Department of Health and Human Services
  5. A Protein Biologic for the Treatment of Sepsis

    SBC: Gencia Corporation            Topic: NIAID

    DESCRIPTION (provided by applicant): Sepsis and related multiple organ dysfunction are a major cause of mortality and morbidity, responsible for over 215 000 deaths per year in the US. Despite growing understanding of the pathomechanism of sepsis, treatment options are still limited primarily to antibiotics, glucocorticoids, and supportive measures. There is wide consensus that mitochondrial dysfu ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Not Available

    SBC: Gencia Corporation            Topic: NCI

    Bioenergetic dysfunction is a well- recognized feature of most (< 97%) metastasizing tumors. Dysfunction of major cell proliferation controllers mutated in the majority of neoplasms, such as the p53, Ras, Myc, PI3K/Akt pathways, results in suppression of mitochondrial oxidative phosphorylation (OXPHOS) and in activation of glycolysis, known as the Warburg effect, which contributes to the resistanc ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. CREATION OF STANDARDS AND DEVELOPMENT OF MOLECULAR CLINICAL DIAGNOSTIC FOR ENTERI

    SBC: PHRIXUS PHARMACEUTICALS, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): This one-year phase I SBIR proposal will apply the benefits of molecular testing, in terms of speed, sensitivity, and ultimately value, to diagnose enteric Microsporidia (Enterocytozoon bieneusi and Encephalitozoon intestinalis). Molecular diagnostics are the future for infectious disease diagnostics, with a projected 13% rate of revenue increase between 2009 a ...

    SBIR Phase I 2010 Department of Health and Human Services
  8. Not Available

    SBC: Indoor Biotechnologies Inc            Topic: NIEHS

    Molds cause asthma and allergic respiratory diseases and are associated with other illnesses such as sinusitis, chronic fatigue syndrome, lethargy, or migraines. Mold occurs in damp or water damaged housing. The relationships between mold exposure and health effects are poorly understood. The aim of this project is to develop a multiplex array for mold biomarkers that will measure 4-7 biomarker ...

    SBIR Phase I 2010 Department of Health and Human Services
  9. Next Generation Capsule Endoscopy Video Data Acquisition and Visualization Platfo

    SBC: Altrum Technologies, Inc            Topic: NCRR

    DESCRIPTION (provided by applicant): Gastrointestinal (GI) malignancies are the most common cause of cancer in the world. Of the 10.8 million people in the world each year who develop cancer, approximately 3.3 million have GI malignancies. Aside from prevention, effective, low cost, and comfortable early diagnosis technologies are urgently needed to improve this situation. Traditional endoscopic o ...

    SBIR Phase I 2010 Department of Health and Human Services
  10. Completely Digitizing the Custom-Fit Hearing Aid Shell Manufacturing Process

    SBC: Altrum Technologies, Inc            Topic: NIDCD

    DESCRIPTION (provided by applicant): The average hearing aid costs 1,500, but prices can go up to 5,000 each. Yet Consumer Reports indicates that 40 percent of hearing aid users are unhappy with their devices. Between 25 percent and 30 percent of custom-fit hearing aids are returned and/or need to be remade and another 20 percent end up sitting unused in a bureau drawer. Just as disturbing, of t ...

    SBIR Phase I 2010 Department of Health and Human Services

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