Award Data

PROJECT SUMMARY Stroke is the fifth largest cause of death and a leading cause of long-term disability among adults in the United States. More than 300 neuroprotective and thrombolytic drug candidates for ischemic stroke have failed in clinical trials between 1995 and 2015, raising concerns regarding the efficacy of preclinical studies. Our long- term goal is to improve the value of animal models ...

Project Summary Abstract We have developed a nutritional formulation of amino acids called UpBeat that is designed to promote physical function and quality of life in older individuals with heart failureReduced exercise capacity is a prominent clinical feature of heart failureThis leads to progressive muscle weakness and a vicious cycle of sedentary behaviorweight gainand subsequent development of ...

Summary The temperature management market is expected to reach $billion byyet no pharmaceutical has yet been developed specifically for this marketAadenosineA ARagonists are well known to attenuate seizure and protect the brain from injurybut development of these drugs has been limited by side effects including hypothermiabradycardia and hypotensionInspired by our discoveries thatN cyclohexyl aden ...

DESCRIPTION provided by applicant The long term goal of this project is to develop and test a nutritional product that will improve physical function in individuals with heart failure H in the geriatric population Our approach to nutritional therapy NT focuses on increasing skeletal muscle strength improving vascular reactivity and optimizing regulation of energy substrate metabolism All ...

DESCRIPTION provided by applicant The overall goal of this project is to test a meal replacement beverage that will ultimately preserve muscle loss during calorie restriction weight loss CRWL in obese older individuals We previously developed a meal replacement rich with a proprietary blend of essential amino acids TMR that was more than three times as effective as whey protein in stimulat ...

DESCRIPTION (provided by applicant): This proposal aims to evaluate the efficacy of Native American ethnobotanical treatments for tuberculosis for the purpose of making available acceptable, affordable alternatives to current TB drugs, especially in developing countries with massive TB case loads such as the People's Republic of China. No new drugs have been introduced for the treatment of tuberc ...

DESCRIPTION (provided by applicant): This Small Business Innovation Research Grant Phase I project is investigating an innovative disinfectant product designed to improve on the limited efficacy of disinfectants used in hospitals. This research is based on the fact that inanimate surfaces in clinical environments frequently harbor viable, pathogenic, and often drug-resistant microorganisms. These ...

DESCRIPTION (provided by applicant): The specific aim of this Phase I SBIR project is to establish the technical merit and feasibility of producing a modular imagery intervention program for breast cancer patients and survivors that can be delivered to patients in a classroom setting, and/or at-a-distance, via Internet. Phase I prototype will emphasize feasibility of delivery and potential efficac ...

DESCRIPTION (provided by applicant): To improve quality of life and reduce stress for breast cancer survivors. Phase II Aims: (1) To demonstrate the clinical efficacy (i.e., improved quality of life, stress reduction, participant satisfaction with product) of the Envision the Rhythms of Life program and (2) to establish the technical merits of the program's distance-delivery (videoconferencing ...

A TREATMENT PROGRAM TO SUCCESSFULLY REVERSE URINARY INCONTINENCE IN MANY OF THE NATION'S 1 MILLION INCONTINENT NURSING HOME PATIENTS HAS RECENTLY BEEN VALIDATED IN EXPERIMENTAL STUDIES. STAFF MANAGEMENT AND TRAINING PROCEDURES HAVE ALSO BEEN EVALUATED DOCUMENTING THAT NURSINGHOMES CAN SUCCESSFULLY IMPLEMENT THE TREATMENT PROCEDURES WITH EXISTING STAFF RESOURCES. THE ENTIRE INCONTINENCE ASSESSMENT, ...